Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery
Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sabino Padilla [verfasserIn] Mikel Sánchez [verfasserIn] Victor Vaquerizo [verfasserIn] Gerard A. Malanga [verfasserIn] Nicolás Fiz [verfasserIn] Juan Azofra [verfasserIn] Christopher J. Rogers [verfasserIn] Gonzalo Samitier [verfasserIn] Steven Sampson [verfasserIn] Roberto Seijas [verfasserIn] Ricardo Elorriaga [verfasserIn] Jack Taunton [verfasserIn] Frank Boehm [verfasserIn] Roberto Prado [verfasserIn] Ramón Cugat [verfasserIn] Eduardo Anitua [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 22(2021), 2, p 824 |
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| Übergeordnetes Werk: |
volume:22 ; year:2021 ; number:2, p 824 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.3390/ijms22020824 |
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| 520 | |a Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task. | ||
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10.3390/ijms22020824 doi (DE-627)DOAJ050892533 (DE-599)DOAJe12d2aafb64b4794962d999136c9a2fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sabino Padilla verfasserin aut Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task. Achilles platelet-rich plasma PRGF tendon Biology (General) Chemistry Mikel Sánchez verfasserin aut Victor Vaquerizo verfasserin aut Gerard A. Malanga verfasserin aut Nicolás Fiz verfasserin aut Juan Azofra verfasserin aut Christopher J. Rogers verfasserin aut Gonzalo Samitier verfasserin aut Steven Sampson verfasserin aut Roberto Seijas verfasserin aut Ricardo Elorriaga verfasserin aut Jack Taunton verfasserin aut Frank Boehm verfasserin aut Roberto Prado verfasserin aut Ramón Cugat verfasserin aut Eduardo Anitua verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 2, p 824 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:2, p 824 https://doi.org/10.3390/ijms22020824 kostenfrei https://doaj.org/article/e12d2aafb64b4794962d999136c9a2fe kostenfrei https://www.mdpi.com/1422-0067/22/2/824 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 2, p 824 |
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10.3390/ijms22020824 doi (DE-627)DOAJ050892533 (DE-599)DOAJe12d2aafb64b4794962d999136c9a2fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sabino Padilla verfasserin aut Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task. Achilles platelet-rich plasma PRGF tendon Biology (General) Chemistry Mikel Sánchez verfasserin aut Victor Vaquerizo verfasserin aut Gerard A. Malanga verfasserin aut Nicolás Fiz verfasserin aut Juan Azofra verfasserin aut Christopher J. Rogers verfasserin aut Gonzalo Samitier verfasserin aut Steven Sampson verfasserin aut Roberto Seijas verfasserin aut Ricardo Elorriaga verfasserin aut Jack Taunton verfasserin aut Frank Boehm verfasserin aut Roberto Prado verfasserin aut Ramón Cugat verfasserin aut Eduardo Anitua verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 2, p 824 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:2, p 824 https://doi.org/10.3390/ijms22020824 kostenfrei https://doaj.org/article/e12d2aafb64b4794962d999136c9a2fe kostenfrei https://www.mdpi.com/1422-0067/22/2/824 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 2, p 824 |
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10.3390/ijms22020824 doi (DE-627)DOAJ050892533 (DE-599)DOAJe12d2aafb64b4794962d999136c9a2fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sabino Padilla verfasserin aut Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task. Achilles platelet-rich plasma PRGF tendon Biology (General) Chemistry Mikel Sánchez verfasserin aut Victor Vaquerizo verfasserin aut Gerard A. Malanga verfasserin aut Nicolás Fiz verfasserin aut Juan Azofra verfasserin aut Christopher J. Rogers verfasserin aut Gonzalo Samitier verfasserin aut Steven Sampson verfasserin aut Roberto Seijas verfasserin aut Ricardo Elorriaga verfasserin aut Jack Taunton verfasserin aut Frank Boehm verfasserin aut Roberto Prado verfasserin aut Ramón Cugat verfasserin aut Eduardo Anitua verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 2, p 824 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:2, p 824 https://doi.org/10.3390/ijms22020824 kostenfrei https://doaj.org/article/e12d2aafb64b4794962d999136c9a2fe kostenfrei https://www.mdpi.com/1422-0067/22/2/824 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 2, p 824 |
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platelet-rich plasma applications for achilles tendon repair: a bridge between biology and surgery |
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Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery |
| abstract |
Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task. |
| abstractGer |
Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task. |
| abstract_unstemmed |
Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task. |
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Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery |
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