Mechanisms promoting and inhibiting the process of proteasomal degradation of cells

Defects in the process of degradation of unneeded cellular proteins underlie many diseases. This article discusses one of the most important systems of removal of abnormal proteins. It describes the process of ubiquitination of proteins for proteasome degradation. It also describes the structure of...
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Gespeichert in:

Autor*in:	Pedrycz Agnieszka [verfasserIn] Kramkowska Agnieszka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	proteasome lysosome UPS – ubiquitin-proteasome system

Übergeordnetes Werk:	In: Current Problems of Psychiatry - Sciendo, 2017, 17(2016), 1, Seite 47-57
Übergeordnetes Werk:	volume:17 ; year:2016 ; number:1 ; pages:47-57

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1515/cpp-2016-0007

Katalog-ID:	DOAJ050892738

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callnumber-first	R - Medicine
author	Pedrycz Agnieszka
spellingShingle	Pedrycz Agnieszka misc RC435-571 misc proteasome misc lysosome misc UPS – ubiquitin-proteasome system misc Psychiatry Mechanisms promoting and inhibiting the process of proteasomal degradation of cells
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topic_title	RC435-571 Mechanisms promoting and inhibiting the process of proteasomal degradation of cells proteasome lysosome UPS – ubiquitin-proteasome system
topic	misc RC435-571 misc proteasome misc lysosome misc UPS – ubiquitin-proteasome system misc Psychiatry
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title	Mechanisms promoting and inhibiting the process of proteasomal degradation of cells
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title_sort	mechanisms promoting and inhibiting the process of proteasomal degradation of cells
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title_auth	Mechanisms promoting and inhibiting the process of proteasomal degradation of cells
abstract	Defects in the process of degradation of unneeded cellular proteins underlie many diseases. This article discusses one of the most important systems of removal of abnormal proteins. It describes the process of ubiquitination of proteins for proteasome degradation. It also describes the structure of the 26S and 20S proteasomes and the mechanism of ubiquitin-proteasome system. Proteasome proteolytic system is highly specialized and organized. Protease-proteasome 26S is particularly important for proper cell functioning. It recognizes and degrades marked proteins. Inhibition of proteasome pathway leads to cell cycle arrest and apoptosis.
abstractGer	Defects in the process of degradation of unneeded cellular proteins underlie many diseases. This article discusses one of the most important systems of removal of abnormal proteins. It describes the process of ubiquitination of proteins for proteasome degradation. It also describes the structure of the 26S and 20S proteasomes and the mechanism of ubiquitin-proteasome system. Proteasome proteolytic system is highly specialized and organized. Protease-proteasome 26S is particularly important for proper cell functioning. It recognizes and degrades marked proteins. Inhibition of proteasome pathway leads to cell cycle arrest and apoptosis.
abstract_unstemmed	Defects in the process of degradation of unneeded cellular proteins underlie many diseases. This article discusses one of the most important systems of removal of abnormal proteins. It describes the process of ubiquitination of proteins for proteasome degradation. It also describes the structure of the 26S and 20S proteasomes and the mechanism of ubiquitin-proteasome system. Proteasome proteolytic system is highly specialized and organized. Protease-proteasome 26S is particularly important for proper cell functioning. It recognizes and degrades marked proteins. Inhibition of proteasome pathway leads to cell cycle arrest and apoptosis.
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title_short	Mechanisms promoting and inhibiting the process of proteasomal degradation of cells
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