Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya

<p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria e...
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Gespeichert in:

Autor*in:	Asito Amolo S [verfasserIn] Piriou Erwan [verfasserIn] Jura Walter GZO [verfasserIn] Ouma Collins [verfasserIn] Odada Peter S [verfasserIn] Ogola Sidney [verfasserIn] Fiore Nancy [verfasserIn] Rochford Rosemary [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	B cells Infant immunity

Übergeordnetes Werk:	In: Malaria Journal - BMC, 2003, 10(2011), 1, p 362
Übergeordnetes Werk:	volume:10 ; year:2011 ; number:1, p 362

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1475-2875-10-362

Katalog-ID:	DOAJ051061562

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p<
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author_variant	a a s aas p e pe j w g jwg o c oc o p s ops o s os f n fn r r rr
matchkey_str	article:14752875:2011----::upesoocruaiggc2mmrbeliifnsiignmlr
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publishDate	2011
allfields	10.1186/1475-2875-10-362 doi (DE-627)DOAJ051061562 (DE-599)DOAJ4adbba9a33d049d98644e026f62d050f DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Asito Amolo S verfasserin aut Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p< B cells Infant immunity <it<Plasmodium falciparum</it< Arctic medicine. Tropical medicine Infectious and parasitic diseases Piriou Erwan verfasserin aut Jura Walter GZO verfasserin aut Ouma Collins verfasserin aut Odada Peter S verfasserin aut Ogola Sidney verfasserin aut Fiore Nancy verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 10(2011), 1, p 362 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:10 year:2011 number:1, p 362 https://doi.org/10.1186/1475-2875-10-362 kostenfrei https://doaj.org/article/4adbba9a33d049d98644e026f62d050f kostenfrei http://www.malariajournal.com/content/10/1/362 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1, p 362
spelling	10.1186/1475-2875-10-362 doi (DE-627)DOAJ051061562 (DE-599)DOAJ4adbba9a33d049d98644e026f62d050f DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Asito Amolo S verfasserin aut Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p< B cells Infant immunity <it<Plasmodium falciparum</it< Arctic medicine. Tropical medicine Infectious and parasitic diseases Piriou Erwan verfasserin aut Jura Walter GZO verfasserin aut Ouma Collins verfasserin aut Odada Peter S verfasserin aut Ogola Sidney verfasserin aut Fiore Nancy verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 10(2011), 1, p 362 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:10 year:2011 number:1, p 362 https://doi.org/10.1186/1475-2875-10-362 kostenfrei https://doaj.org/article/4adbba9a33d049d98644e026f62d050f kostenfrei http://www.malariajournal.com/content/10/1/362 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1, p 362
allfields_unstemmed	10.1186/1475-2875-10-362 doi (DE-627)DOAJ051061562 (DE-599)DOAJ4adbba9a33d049d98644e026f62d050f DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Asito Amolo S verfasserin aut Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p< B cells Infant immunity <it<Plasmodium falciparum</it< Arctic medicine. Tropical medicine Infectious and parasitic diseases Piriou Erwan verfasserin aut Jura Walter GZO verfasserin aut Ouma Collins verfasserin aut Odada Peter S verfasserin aut Ogola Sidney verfasserin aut Fiore Nancy verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 10(2011), 1, p 362 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:10 year:2011 number:1, p 362 https://doi.org/10.1186/1475-2875-10-362 kostenfrei https://doaj.org/article/4adbba9a33d049d98644e026f62d050f kostenfrei http://www.malariajournal.com/content/10/1/362 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1, p 362
allfieldsGer	10.1186/1475-2875-10-362 doi (DE-627)DOAJ051061562 (DE-599)DOAJ4adbba9a33d049d98644e026f62d050f DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Asito Amolo S verfasserin aut Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p< B cells Infant immunity <it<Plasmodium falciparum</it< Arctic medicine. Tropical medicine Infectious and parasitic diseases Piriou Erwan verfasserin aut Jura Walter GZO verfasserin aut Ouma Collins verfasserin aut Odada Peter S verfasserin aut Ogola Sidney verfasserin aut Fiore Nancy verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 10(2011), 1, p 362 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:10 year:2011 number:1, p 362 https://doi.org/10.1186/1475-2875-10-362 kostenfrei https://doaj.org/article/4adbba9a33d049d98644e026f62d050f kostenfrei http://www.malariajournal.com/content/10/1/362 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1, p 362
allfieldsSound	10.1186/1475-2875-10-362 doi (DE-627)DOAJ051061562 (DE-599)DOAJ4adbba9a33d049d98644e026f62d050f DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Asito Amolo S verfasserin aut Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p< B cells Infant immunity <it<Plasmodium falciparum</it< Arctic medicine. Tropical medicine Infectious and parasitic diseases Piriou Erwan verfasserin aut Jura Walter GZO verfasserin aut Ouma Collins verfasserin aut Odada Peter S verfasserin aut Ogola Sidney verfasserin aut Fiore Nancy verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 10(2011), 1, p 362 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:10 year:2011 number:1, p 362 https://doi.org/10.1186/1475-2875-10-362 kostenfrei https://doaj.org/article/4adbba9a33d049d98644e026f62d050f kostenfrei http://www.malariajournal.com/content/10/1/362 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1, p 362
language	English
source	In Malaria Journal 10(2011), 1, p 362 volume:10 year:2011 number:1, p 362
sourceStr	In Malaria Journal 10(2011), 1, p 362 volume:10 year:2011 number:1, p 362
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	B cells Infant immunity <it<Plasmodium falciparum</it< Arctic medicine. Tropical medicine Infectious and parasitic diseases
isfreeaccess_bool	true
container_title	Malaria Journal
authorswithroles_txt_mv	Asito Amolo S @@aut@@ Piriou Erwan @@aut@@ Jura Walter GZO @@aut@@ Ouma Collins @@aut@@ Odada Peter S @@aut@@ Ogola Sidney @@aut@@ Fiore Nancy @@aut@@ Rochford Rosemary @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
hierarchy_top_id	355986582
id	DOAJ051061562
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ051061562</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308155925.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2011 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1475-2875-10-362</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ051061562</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ4adbba9a33d049d98644e026f62d050f</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC955-962</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC109-216</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Asito Amolo S</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2011</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">B cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Infant immunity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><it<Plasmodium falciparum</it<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Arctic medicine. 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callnumber-first	R - Medicine
author	Asito Amolo S
spellingShingle	Asito Amolo S misc RC955-962 misc RC109-216 misc B cells misc Infant immunity misc <it<Plasmodium falciparum</it< misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya
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topic_title	RC955-962 RC109-216 Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya B cells Infant immunity <it<Plasmodium falciparum</it<
topic	misc RC955-962 misc RC109-216 misc B cells misc Infant immunity misc <it<Plasmodium falciparum</it< misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases
topic_unstemmed	misc RC955-962 misc RC109-216 misc B cells misc Infant immunity misc <it<Plasmodium falciparum</it< misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases
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title	Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya
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title_full	Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya
author_sort	Asito Amolo S
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author_browse	Asito Amolo S Piriou Erwan Jura Walter GZO Ouma Collins Odada Peter S Ogola Sidney Fiore Nancy Rochford Rosemary
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title_sort	suppression of circulating igd+cd27+ memory b cells in infants living in a malaria-endemic region of kenya
callnumber	RC955-962
title_auth	Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya
abstract	<p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<<it<Plasmodium falciparum </it<infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to <it<P. falciparum </it<and heterologous infections.</p<
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title_short	Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya
url	https://doi.org/10.1186/1475-2875-10-362 https://doaj.org/article/4adbba9a33d049d98644e026f62d050f http://www.malariajournal.com/content/10/1/362 https://doaj.org/toc/1475-2875
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During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect.</p< <p<Methods</p< <p<To evaluate the impact of exposure to <it<P. falciparum </it<on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21).</p< <p<Results</p< <p<There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(<it<p </it<= 0.0440), 18(<it<p </it<= 0.0210) and 24 months (<it<p </it<= 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (<it<p </it<= 0.0144), 18 (<it<p </it<= 0.0013) and 24 months (<it<p </it<= 0.0129).</p< <p<Conclusions</p< <p<These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. 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Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya

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