Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes
Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan;...
Ausführliche Beschreibung
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| Autor*in: |
Deng X [verfasserIn] Zhao L [verfasserIn] Guo C [verfasserIn] Yang L [verfasserIn] Wang D [verfasserIn] Li Y [verfasserIn] Xia H [verfasserIn] Wang C [verfasserIn] Cai Z [verfasserIn] Li L [verfasserIn] Zhao Z [verfasserIn] Yuan G [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2020 |
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In: Diabetes, Metabolic Syndrome and Obesity - Dove Medical Press, 2009, (2020), Seite 4341-4351 |
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| Übergeordnetes Werk: |
year:2020 ; pages:4341-4351 |
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DOAJ051229471 |
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| 520 | |a Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy | ||
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(DE-627)DOAJ051229471 (DE-599)DOAJ7b4a0de4a96b46aeb048de5b78c74bc3 DE-627 ger DE-627 rakwb eng RC581-951 Deng X verfasserin aut Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy asprosin type 2 diabetes mellitus diabetic nephropathy Specialties of internal medicine Zhao L verfasserin aut Guo C verfasserin aut Yang L verfasserin aut Wang D verfasserin aut Li Y verfasserin aut Xia H verfasserin aut Wang C verfasserin aut Cai Z verfasserin aut Li L verfasserin aut Zhao Z verfasserin aut Yuan G verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2020), Seite 4341-4351 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2020 pages:4341-4351 https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc3 kostenfrei https://www.dovepress.com/higher-serum-asprosin-level-is-associated-with-urinary-albumin-excreti-peer-reviewed-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4341-4351 |
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(DE-627)DOAJ051229471 (DE-599)DOAJ7b4a0de4a96b46aeb048de5b78c74bc3 DE-627 ger DE-627 rakwb eng RC581-951 Deng X verfasserin aut Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy asprosin type 2 diabetes mellitus diabetic nephropathy Specialties of internal medicine Zhao L verfasserin aut Guo C verfasserin aut Yang L verfasserin aut Wang D verfasserin aut Li Y verfasserin aut Xia H verfasserin aut Wang C verfasserin aut Cai Z verfasserin aut Li L verfasserin aut Zhao Z verfasserin aut Yuan G verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2020), Seite 4341-4351 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2020 pages:4341-4351 https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc3 kostenfrei https://www.dovepress.com/higher-serum-asprosin-level-is-associated-with-urinary-albumin-excreti-peer-reviewed-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4341-4351 |
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(DE-627)DOAJ051229471 (DE-599)DOAJ7b4a0de4a96b46aeb048de5b78c74bc3 DE-627 ger DE-627 rakwb eng RC581-951 Deng X verfasserin aut Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy asprosin type 2 diabetes mellitus diabetic nephropathy Specialties of internal medicine Zhao L verfasserin aut Guo C verfasserin aut Yang L verfasserin aut Wang D verfasserin aut Li Y verfasserin aut Xia H verfasserin aut Wang C verfasserin aut Cai Z verfasserin aut Li L verfasserin aut Zhao Z verfasserin aut Yuan G verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2020), Seite 4341-4351 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2020 pages:4341-4351 https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc3 kostenfrei https://www.dovepress.com/higher-serum-asprosin-level-is-associated-with-urinary-albumin-excreti-peer-reviewed-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4341-4351 |
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(DE-627)DOAJ051229471 (DE-599)DOAJ7b4a0de4a96b46aeb048de5b78c74bc3 DE-627 ger DE-627 rakwb eng RC581-951 Deng X verfasserin aut Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy asprosin type 2 diabetes mellitus diabetic nephropathy Specialties of internal medicine Zhao L verfasserin aut Guo C verfasserin aut Yang L verfasserin aut Wang D verfasserin aut Li Y verfasserin aut Xia H verfasserin aut Wang C verfasserin aut Cai Z verfasserin aut Li L verfasserin aut Zhao Z verfasserin aut Yuan G verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2020), Seite 4341-4351 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2020 pages:4341-4351 https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc3 kostenfrei https://www.dovepress.com/higher-serum-asprosin-level-is-associated-with-urinary-albumin-excreti-peer-reviewed-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4341-4351 |
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(DE-627)DOAJ051229471 (DE-599)DOAJ7b4a0de4a96b46aeb048de5b78c74bc3 DE-627 ger DE-627 rakwb eng RC581-951 Deng X verfasserin aut Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy asprosin type 2 diabetes mellitus diabetic nephropathy Specialties of internal medicine Zhao L verfasserin aut Guo C verfasserin aut Yang L verfasserin aut Wang D verfasserin aut Li Y verfasserin aut Xia H verfasserin aut Wang C verfasserin aut Cai Z verfasserin aut Li L verfasserin aut Zhao Z verfasserin aut Yuan G verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2020), Seite 4341-4351 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2020 pages:4341-4351 https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc3 kostenfrei https://www.dovepress.com/higher-serum-asprosin-level-is-associated-with-urinary-albumin-excreti-peer-reviewed-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4341-4351 |
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Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63&ndash; 3.57)] and microalbuminuria [2.10 (1.60&ndash; 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18&ndash; 2.09)] (P&lt; 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P&lt; 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P&lt; 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P&lt; 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37&sim; 2.928), P &lt; 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">asprosin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">type 2 diabetes mellitus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">diabetic nephropathy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Specialties of internal medicine</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zhao 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Deng X |
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RC581-951 Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes asprosin type 2 diabetes mellitus diabetic nephropathy |
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Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes |
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Diabetes, Metabolic Syndrome and Obesity |
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Deng X Zhao L Guo C Yang L Wang D Li Y Xia H Wang C Cai Z Li L Zhao Z Yuan G |
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higher serum asprosin level is associated with urinary albumin excretion and renal function in type 2 diabetes |
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Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes |
| abstract |
Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy |
| abstractGer |
Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy |
| abstract_unstemmed |
Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyueujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=- 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy |
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