Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1...
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Autor*in:	Teng Teng [verfasserIn] Jennifer HC Tsai [verfasserIn] Xiaoling Puyang [verfasserIn] Michael Seiler [verfasserIn] Shouyong Peng [verfasserIn] Sudeep Prajapati [verfasserIn] Daniel Aird [verfasserIn] Silvia Buonamici [verfasserIn] Benjamin Caleb [verfasserIn] Betty Chan [verfasserIn] Laura Corson [verfasserIn] Jacob Feala [verfasserIn] Peter Fekkes [verfasserIn] Baudouin Gerard [verfasserIn] Craig Karr [verfasserIn] Manav Korpal [verfasserIn] Xiang Liu [verfasserIn] Jason T. Lowe [verfasserIn] Yoshiharu Mizui [verfasserIn] James Palacino [verfasserIn] Eunice Park [verfasserIn] Peter G. Smith [verfasserIn] Vanitha Subramanian [verfasserIn] Zhenhua Jeremy Wu [verfasserIn] Jian Zou [verfasserIn] Lihua Yu [verfasserIn] Agustin Chicas [verfasserIn] Markus Warmuth [verfasserIn] Nicholas Larsen [verfasserIn] Ping Zhu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 16
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/ncomms15522

Katalog-ID:	DOAJ051278065

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allfields	10.1038/ncomms15522 doi (DE-627)DOAJ051278065 (DE-599)DOAJbcd02552d59140f1871d75acbfffec14 DE-627 ger DE-627 rakwb eng Teng Teng verfasserin aut Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex. Science Q Jennifer HC Tsai verfasserin aut Xiaoling Puyang verfasserin aut Michael Seiler verfasserin aut Shouyong Peng verfasserin aut Sudeep Prajapati verfasserin aut Daniel Aird verfasserin aut Silvia Buonamici verfasserin aut Benjamin Caleb verfasserin aut Betty Chan verfasserin aut Laura Corson verfasserin aut Jacob Feala verfasserin aut Peter Fekkes verfasserin aut Baudouin Gerard verfasserin aut Craig Karr verfasserin aut Manav Korpal verfasserin aut Xiang Liu verfasserin aut Jason T. Lowe verfasserin aut Yoshiharu Mizui verfasserin aut James Palacino verfasserin aut Eunice Park verfasserin aut Peter G. Smith verfasserin aut Vanitha Subramanian verfasserin aut Zhenhua Jeremy Wu verfasserin aut Jian Zou verfasserin aut Lihua Yu verfasserin aut Agustin Chicas verfasserin aut Markus Warmuth verfasserin aut Nicholas Larsen verfasserin aut Ping Zhu verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:16 https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/article/bcd02552d59140f1871d75acbfffec14 kostenfrei https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 16
spelling	10.1038/ncomms15522 doi (DE-627)DOAJ051278065 (DE-599)DOAJbcd02552d59140f1871d75acbfffec14 DE-627 ger DE-627 rakwb eng Teng Teng verfasserin aut Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex. Science Q Jennifer HC Tsai verfasserin aut Xiaoling Puyang verfasserin aut Michael Seiler verfasserin aut Shouyong Peng verfasserin aut Sudeep Prajapati verfasserin aut Daniel Aird verfasserin aut Silvia Buonamici verfasserin aut Benjamin Caleb verfasserin aut Betty Chan verfasserin aut Laura Corson verfasserin aut Jacob Feala verfasserin aut Peter Fekkes verfasserin aut Baudouin Gerard verfasserin aut Craig Karr verfasserin aut Manav Korpal verfasserin aut Xiang Liu verfasserin aut Jason T. Lowe verfasserin aut Yoshiharu Mizui verfasserin aut James Palacino verfasserin aut Eunice Park verfasserin aut Peter G. Smith verfasserin aut Vanitha Subramanian verfasserin aut Zhenhua Jeremy Wu verfasserin aut Jian Zou verfasserin aut Lihua Yu verfasserin aut Agustin Chicas verfasserin aut Markus Warmuth verfasserin aut Nicholas Larsen verfasserin aut Ping Zhu verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:16 https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/article/bcd02552d59140f1871d75acbfffec14 kostenfrei https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 16
allfields_unstemmed	10.1038/ncomms15522 doi (DE-627)DOAJ051278065 (DE-599)DOAJbcd02552d59140f1871d75acbfffec14 DE-627 ger DE-627 rakwb eng Teng Teng verfasserin aut Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex. Science Q Jennifer HC Tsai verfasserin aut Xiaoling Puyang verfasserin aut Michael Seiler verfasserin aut Shouyong Peng verfasserin aut Sudeep Prajapati verfasserin aut Daniel Aird verfasserin aut Silvia Buonamici verfasserin aut Benjamin Caleb verfasserin aut Betty Chan verfasserin aut Laura Corson verfasserin aut Jacob Feala verfasserin aut Peter Fekkes verfasserin aut Baudouin Gerard verfasserin aut Craig Karr verfasserin aut Manav Korpal verfasserin aut Xiang Liu verfasserin aut Jason T. Lowe verfasserin aut Yoshiharu Mizui verfasserin aut James Palacino verfasserin aut Eunice Park verfasserin aut Peter G. Smith verfasserin aut Vanitha Subramanian verfasserin aut Zhenhua Jeremy Wu verfasserin aut Jian Zou verfasserin aut Lihua Yu verfasserin aut Agustin Chicas verfasserin aut Markus Warmuth verfasserin aut Nicholas Larsen verfasserin aut Ping Zhu verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:16 https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/article/bcd02552d59140f1871d75acbfffec14 kostenfrei https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 16
allfieldsGer	10.1038/ncomms15522 doi (DE-627)DOAJ051278065 (DE-599)DOAJbcd02552d59140f1871d75acbfffec14 DE-627 ger DE-627 rakwb eng Teng Teng verfasserin aut Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex. Science Q Jennifer HC Tsai verfasserin aut Xiaoling Puyang verfasserin aut Michael Seiler verfasserin aut Shouyong Peng verfasserin aut Sudeep Prajapati verfasserin aut Daniel Aird verfasserin aut Silvia Buonamici verfasserin aut Benjamin Caleb verfasserin aut Betty Chan verfasserin aut Laura Corson verfasserin aut Jacob Feala verfasserin aut Peter Fekkes verfasserin aut Baudouin Gerard verfasserin aut Craig Karr verfasserin aut Manav Korpal verfasserin aut Xiang Liu verfasserin aut Jason T. Lowe verfasserin aut Yoshiharu Mizui verfasserin aut James Palacino verfasserin aut Eunice Park verfasserin aut Peter G. Smith verfasserin aut Vanitha Subramanian verfasserin aut Zhenhua Jeremy Wu verfasserin aut Jian Zou verfasserin aut Lihua Yu verfasserin aut Agustin Chicas verfasserin aut Markus Warmuth verfasserin aut Nicholas Larsen verfasserin aut Ping Zhu verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:16 https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/article/bcd02552d59140f1871d75acbfffec14 kostenfrei https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 16
allfieldsSound	10.1038/ncomms15522 doi (DE-627)DOAJ051278065 (DE-599)DOAJbcd02552d59140f1871d75acbfffec14 DE-627 ger DE-627 rakwb eng Teng Teng verfasserin aut Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex. Science Q Jennifer HC Tsai verfasserin aut Xiaoling Puyang verfasserin aut Michael Seiler verfasserin aut Shouyong Peng verfasserin aut Sudeep Prajapati verfasserin aut Daniel Aird verfasserin aut Silvia Buonamici verfasserin aut Benjamin Caleb verfasserin aut Betty Chan verfasserin aut Laura Corson verfasserin aut Jacob Feala verfasserin aut Peter Fekkes verfasserin aut Baudouin Gerard verfasserin aut Craig Karr verfasserin aut Manav Korpal verfasserin aut Xiang Liu verfasserin aut Jason T. Lowe verfasserin aut Yoshiharu Mizui verfasserin aut James Palacino verfasserin aut Eunice Park verfasserin aut Peter G. Smith verfasserin aut Vanitha Subramanian verfasserin aut Zhenhua Jeremy Wu verfasserin aut Jian Zou verfasserin aut Lihua Yu verfasserin aut Agustin Chicas verfasserin aut Markus Warmuth verfasserin aut Nicholas Larsen verfasserin aut Ping Zhu verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:16 https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/article/bcd02552d59140f1871d75acbfffec14 kostenfrei https://doi.org/10.1038/ncomms15522 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 16
language	English
source	In Nature Communications 8(2017), 1, Seite 16 volume:8 year:2017 number:1 pages:16
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authorswithroles_txt_mv	Teng Teng @@aut@@ Jennifer HC Tsai @@aut@@ Xiaoling Puyang @@aut@@ Michael Seiler @@aut@@ Shouyong Peng @@aut@@ Sudeep Prajapati @@aut@@ Daniel Aird @@aut@@ Silvia Buonamici @@aut@@ Benjamin Caleb @@aut@@ Betty Chan @@aut@@ Laura Corson @@aut@@ Jacob Feala @@aut@@ Peter Fekkes @@aut@@ Baudouin Gerard @@aut@@ Craig Karr @@aut@@ Manav Korpal @@aut@@ Xiang Liu @@aut@@ Jason T. Lowe @@aut@@ Yoshiharu Mizui @@aut@@ James Palacino @@aut@@ Eunice Park @@aut@@ Peter G. Smith @@aut@@ Vanitha Subramanian @@aut@@ Zhenhua Jeremy Wu @@aut@@ Jian Zou @@aut@@ Lihua Yu @@aut@@ Agustin Chicas @@aut@@ Markus Warmuth @@aut@@ Nicholas Larsen @@aut@@ Ping Zhu @@aut@@
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author	Teng Teng
spellingShingle	Teng Teng misc Science misc Q Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
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topic_title	Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
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title	Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
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title_full	Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
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author_browse	Teng Teng Jennifer HC Tsai Xiaoling Puyang Michael Seiler Shouyong Peng Sudeep Prajapati Daniel Aird Silvia Buonamici Benjamin Caleb Betty Chan Laura Corson Jacob Feala Peter Fekkes Baudouin Gerard Craig Karr Manav Korpal Xiang Liu Jason T. Lowe Yoshiharu Mizui James Palacino Eunice Park Peter G. Smith Vanitha Subramanian Zhenhua Jeremy Wu Jian Zou Lihua Yu Agustin Chicas Markus Warmuth Nicholas Larsen Ping Zhu
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title_sort	splicing modulators act at the branch point adenosine binding pocket defined by the phf5a–sf3b complex
title_auth	Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
abstract	A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex.
abstractGer	A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex.
abstract_unstemmed	A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex.
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title_short	Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
url	https://doi.org/10.1038/ncomms15522 https://doaj.org/article/bcd02552d59140f1871d75acbfffec14 https://doaj.org/toc/2041-1723
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author2	Jennifer HC Tsai Xiaoling Puyang Michael Seiler Shouyong Peng Sudeep Prajapati Daniel Aird Silvia Buonamici Benjamin Caleb Betty Chan Laura Corson Jacob Feala Peter Fekkes Baudouin Gerard Craig Karr Manav Korpal Xiang Liu Jason T. Lowe Yoshiharu Mizui James Palacino Eunice Park Peter G. Smith Vanitha Subramanian Zhenhua Jeremy Wu Jian Zou Lihua Yu Agustin Chicas Markus Warmuth Nicholas Larsen Ping Zhu
author2Str	Jennifer HC Tsai Xiaoling Puyang Michael Seiler Shouyong Peng Sudeep Prajapati Daniel Aird Silvia Buonamici Benjamin Caleb Betty Chan Laura Corson Jacob Feala Peter Fekkes Baudouin Gerard Craig Karr Manav Korpal Xiang Liu Jason T. Lowe Yoshiharu Mizui James Palacino Eunice Park Peter G. Smith Vanitha Subramanian Zhenhua Jeremy Wu Jian Zou Lihua Yu Agustin Chicas Markus Warmuth Nicholas Larsen Ping Zhu
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up_date	2024-07-03T19:25:02.311Z
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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

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