Antitumoral Activities of Curcumin and Recent Advances to ImProve Its Oral Bioavailability

Curcumin, a main bioactive component of the <i<Curcuma longa</i< L. rhizome, is a phenolic compound that exerts a wide range of beneficial effects, acting as an antimicrobial, antioxidant, anti-inflammatory and anticancer agent. This review summarizes recent data on curcumin’s ability to...
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Autor*in:	Marta Claudia Nocito [verfasserIn] Arianna De Luca [verfasserIn] Francesca Prestia [verfasserIn] Paola Avena [verfasserIn] Davide La Padula [verfasserIn] Lucia Zavaglia [verfasserIn] Rosa Sirianni [verfasserIn] Ivan Casaburi [verfasserIn] Francesco Puoci [verfasserIn] Adele Chimento [verfasserIn] Vincenzo Pezzi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	curcumin cancer cells bioavailability curcumin derivatives curcumin analogues curcumin delivery systems

Übergeordnetes Werk:	In: Biomedicines - MDPI AG, 2014, 9(2021), 10, p 1476
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:10, p 1476

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomedicines9101476

Katalog-ID:	DOAJ051319667

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allfieldsSound	10.3390/biomedicines9101476 doi (DE-627)DOAJ051319667 (DE-599)DOAJ34f2ccf2aee44360ba60e99723596fa7 DE-627 ger DE-627 rakwb eng QH301-705.5 Marta Claudia Nocito verfasserin aut Antitumoral Activities of Curcumin and Recent Advances to ImProve Its Oral Bioavailability 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Curcumin, a main bioactive component of the <i<Curcuma longa</i< L. rhizome, is a phenolic compound that exerts a wide range of beneficial effects, acting as an antimicrobial, antioxidant, anti-inflammatory and anticancer agent. This review summarizes recent data on curcumin’s ability to interfere with the multiple cell signaling pathways involved in cell cycle regulation, apoptosis and the migration of several cancer cell types. However, although curcumin displays anticancer potential, its clinical application is limited by its low absorption, rapid metabolism and poor bioavailability. To overcome these limitations, several curcumin-based derivatives/analogues and different drug delivery approaches have been developed. Here, we also report the anticancer mechanisms and pharmacokinetic characteristics of some derivatives/analogues and the delivery systems used. These strategies, although encouraging, require additional in vivo studies to support curcumin clinical applications. curcumin cancer cells bioavailability curcumin derivatives curcumin analogues curcumin delivery systems Biology (General) Arianna De Luca verfasserin aut Francesca Prestia verfasserin aut Paola Avena verfasserin aut Davide La Padula verfasserin aut Lucia Zavaglia verfasserin aut Rosa Sirianni verfasserin aut Ivan Casaburi verfasserin aut Francesco Puoci verfasserin aut Adele Chimento verfasserin aut Vincenzo Pezzi verfasserin aut In Biomedicines MDPI AG, 2014 9(2021), 10, p 1476 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:9 year:2021 number:10, p 1476 https://doi.org/10.3390/biomedicines9101476 kostenfrei https://doaj.org/article/34f2ccf2aee44360ba60e99723596fa7 kostenfrei https://www.mdpi.com/2227-9059/9/10/1476 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 10, p 1476
language	English
source	In Biomedicines 9(2021), 10, p 1476 volume:9 year:2021 number:10, p 1476
sourceStr	In Biomedicines 9(2021), 10, p 1476 volume:9 year:2021 number:10, p 1476
format_phy_str_mv	Article
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topic_facet	curcumin cancer cells bioavailability curcumin derivatives curcumin analogues curcumin delivery systems Biology (General)
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container_title	Biomedicines
authorswithroles_txt_mv	Marta Claudia Nocito @@aut@@ Arianna De Luca @@aut@@ Francesca Prestia @@aut@@ Paola Avena @@aut@@ Davide La Padula @@aut@@ Lucia Zavaglia @@aut@@ Rosa Sirianni @@aut@@ Ivan Casaburi @@aut@@ Francesco Puoci @@aut@@ Adele Chimento @@aut@@ Vincenzo Pezzi @@aut@@
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title_sort	antitumoral activities of curcumin and recent advances to improve its oral bioavailability
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title_auth	Antitumoral Activities of Curcumin and Recent Advances to ImProve Its Oral Bioavailability
abstract	Curcumin, a main bioactive component of the <i<Curcuma longa</i< L. rhizome, is a phenolic compound that exerts a wide range of beneficial effects, acting as an antimicrobial, antioxidant, anti-inflammatory and anticancer agent. This review summarizes recent data on curcumin’s ability to interfere with the multiple cell signaling pathways involved in cell cycle regulation, apoptosis and the migration of several cancer cell types. However, although curcumin displays anticancer potential, its clinical application is limited by its low absorption, rapid metabolism and poor bioavailability. To overcome these limitations, several curcumin-based derivatives/analogues and different drug delivery approaches have been developed. Here, we also report the anticancer mechanisms and pharmacokinetic characteristics of some derivatives/analogues and the delivery systems used. These strategies, although encouraging, require additional in vivo studies to support curcumin clinical applications.
abstractGer	Curcumin, a main bioactive component of the <i<Curcuma longa</i< L. rhizome, is a phenolic compound that exerts a wide range of beneficial effects, acting as an antimicrobial, antioxidant, anti-inflammatory and anticancer agent. This review summarizes recent data on curcumin’s ability to interfere with the multiple cell signaling pathways involved in cell cycle regulation, apoptosis and the migration of several cancer cell types. However, although curcumin displays anticancer potential, its clinical application is limited by its low absorption, rapid metabolism and poor bioavailability. To overcome these limitations, several curcumin-based derivatives/analogues and different drug delivery approaches have been developed. Here, we also report the anticancer mechanisms and pharmacokinetic characteristics of some derivatives/analogues and the delivery systems used. These strategies, although encouraging, require additional in vivo studies to support curcumin clinical applications.
abstract_unstemmed	Curcumin, a main bioactive component of the <i<Curcuma longa</i< L. rhizome, is a phenolic compound that exerts a wide range of beneficial effects, acting as an antimicrobial, antioxidant, anti-inflammatory and anticancer agent. This review summarizes recent data on curcumin’s ability to interfere with the multiple cell signaling pathways involved in cell cycle regulation, apoptosis and the migration of several cancer cell types. However, although curcumin displays anticancer potential, its clinical application is limited by its low absorption, rapid metabolism and poor bioavailability. To overcome these limitations, several curcumin-based derivatives/analogues and different drug delivery approaches have been developed. Here, we also report the anticancer mechanisms and pharmacokinetic characteristics of some derivatives/analogues and the delivery systems used. These strategies, although encouraging, require additional in vivo studies to support curcumin clinical applications.
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title_short	Antitumoral Activities of Curcumin and Recent Advances to ImProve Its Oral Bioavailability
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