Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review

The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. W...
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Gespeichert in:

Autor*in:	Johan C. A. de Klerk [verfasserIn] Aline G. J. Engbers [verfasserIn] Floor van Beek [verfasserIn] Robert B. Flint [verfasserIn] Irwin K. M. Reiss [verfasserIn] Swantje Völler [verfasserIn] Sinno H. P. Simons [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	patent ductus arteriosus spontaneous closure preterm infants systematic review VLBW ELBW

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 8(2020)
Übergeordnetes Werk:	volume:8 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2020.00541

Katalog-ID:	DOAJ051504073

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spelling	10.3389/fped.2020.00541 doi (DE-627)DOAJ051504073 (DE-599)DOAJf85004a4f15d4332ba261ee1c338e432 DE-627 ger DE-627 rakwb eng RJ1-570 Johan C. A. de Klerk verfasserin aut Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to 55% on day 3 and 78% on day 7). The probability of spontaneous closure of the ductus arteriosus keeps increasing until at least 1 week after birth which favors delayed treatment of only those infants that do not show spontaneous closure. Better prediction of the spontaneous closure of the ductus arteriosus in the individual newborn is a key factor to find the optimal management strategy for PDA in preterm infants. patent ductus arteriosus spontaneous closure preterm infants systematic review VLBW ELBW Pediatrics Aline G. J. Engbers verfasserin aut Aline G. J. Engbers verfasserin aut Floor van Beek verfasserin aut Robert B. Flint verfasserin aut Robert B. Flint verfasserin aut Irwin K. M. Reiss verfasserin aut Swantje Völler verfasserin aut Swantje Völler verfasserin aut Sinno H. P. Simons verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2020) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2020 https://doi.org/10.3389/fped.2020.00541 kostenfrei https://doaj.org/article/f85004a4f15d4332ba261ee1c338e432 kostenfrei https://www.frontiersin.org/article/10.3389/fped.2020.00541/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020
allfields_unstemmed	10.3389/fped.2020.00541 doi (DE-627)DOAJ051504073 (DE-599)DOAJf85004a4f15d4332ba261ee1c338e432 DE-627 ger DE-627 rakwb eng RJ1-570 Johan C. A. de Klerk verfasserin aut Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to 55% on day 3 and 78% on day 7). The probability of spontaneous closure of the ductus arteriosus keeps increasing until at least 1 week after birth which favors delayed treatment of only those infants that do not show spontaneous closure. Better prediction of the spontaneous closure of the ductus arteriosus in the individual newborn is a key factor to find the optimal management strategy for PDA in preterm infants. patent ductus arteriosus spontaneous closure preterm infants systematic review VLBW ELBW Pediatrics Aline G. J. Engbers verfasserin aut Aline G. J. Engbers verfasserin aut Floor van Beek verfasserin aut Robert B. Flint verfasserin aut Robert B. Flint verfasserin aut Irwin K. M. Reiss verfasserin aut Swantje Völler verfasserin aut Swantje Völler verfasserin aut Sinno H. P. Simons verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2020) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2020 https://doi.org/10.3389/fped.2020.00541 kostenfrei https://doaj.org/article/f85004a4f15d4332ba261ee1c338e432 kostenfrei https://www.frontiersin.org/article/10.3389/fped.2020.00541/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020
allfieldsGer	10.3389/fped.2020.00541 doi (DE-627)DOAJ051504073 (DE-599)DOAJf85004a4f15d4332ba261ee1c338e432 DE-627 ger DE-627 rakwb eng RJ1-570 Johan C. A. de Klerk verfasserin aut Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to 55% on day 3 and 78% on day 7). The probability of spontaneous closure of the ductus arteriosus keeps increasing until at least 1 week after birth which favors delayed treatment of only those infants that do not show spontaneous closure. Better prediction of the spontaneous closure of the ductus arteriosus in the individual newborn is a key factor to find the optimal management strategy for PDA in preterm infants. patent ductus arteriosus spontaneous closure preterm infants systematic review VLBW ELBW Pediatrics Aline G. J. Engbers verfasserin aut Aline G. J. Engbers verfasserin aut Floor van Beek verfasserin aut Robert B. Flint verfasserin aut Robert B. Flint verfasserin aut Irwin K. M. Reiss verfasserin aut Swantje Völler verfasserin aut Swantje Völler verfasserin aut Sinno H. P. Simons verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2020) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2020 https://doi.org/10.3389/fped.2020.00541 kostenfrei https://doaj.org/article/f85004a4f15d4332ba261ee1c338e432 kostenfrei https://www.frontiersin.org/article/10.3389/fped.2020.00541/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020
allfieldsSound	10.3389/fped.2020.00541 doi (DE-627)DOAJ051504073 (DE-599)DOAJf85004a4f15d4332ba261ee1c338e432 DE-627 ger DE-627 rakwb eng RJ1-570 Johan C. A. de Klerk verfasserin aut Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to 55% on day 3 and 78% on day 7). The probability of spontaneous closure of the ductus arteriosus keeps increasing until at least 1 week after birth which favors delayed treatment of only those infants that do not show spontaneous closure. Better prediction of the spontaneous closure of the ductus arteriosus in the individual newborn is a key factor to find the optimal management strategy for PDA in preterm infants. patent ductus arteriosus spontaneous closure preterm infants systematic review VLBW ELBW Pediatrics Aline G. J. Engbers verfasserin aut Aline G. J. Engbers verfasserin aut Floor van Beek verfasserin aut Robert B. Flint verfasserin aut Robert B. Flint verfasserin aut Irwin K. M. Reiss verfasserin aut Swantje Völler verfasserin aut Swantje Völler verfasserin aut Sinno H. P. Simons verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2020) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2020 https://doi.org/10.3389/fped.2020.00541 kostenfrei https://doaj.org/article/f85004a4f15d4332ba261ee1c338e432 kostenfrei https://www.frontiersin.org/article/10.3389/fped.2020.00541/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020
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callnumber-first	R - Medicine
author	Johan C. A. de Klerk
spellingShingle	Johan C. A. de Klerk misc RJ1-570 misc patent ductus arteriosus misc spontaneous closure misc preterm infants misc systematic review misc VLBW misc ELBW misc Pediatrics Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review
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topic_title	RJ1-570 Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review patent ductus arteriosus spontaneous closure preterm infants systematic review VLBW ELBW
topic	misc RJ1-570 misc patent ductus arteriosus misc spontaneous closure misc preterm infants misc systematic review misc VLBW misc ELBW misc Pediatrics
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title	Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review
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title_full	Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review
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author_browse	Johan C. A. de Klerk Aline G. J. Engbers Floor van Beek Robert B. Flint Irwin K. M. Reiss Swantje Völler Sinno H. P. Simons
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title_sort	spontaneous closure of the ductus arteriosus in preterm infants: a systematic review
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title_auth	Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review
abstract	The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to 55% on day 3 and 78% on day 7). The probability of spontaneous closure of the ductus arteriosus keeps increasing until at least 1 week after birth which favors delayed treatment of only those infants that do not show spontaneous closure. Better prediction of the spontaneous closure of the ductus arteriosus in the individual newborn is a key factor to find the optimal management strategy for PDA in preterm infants.
abstractGer	The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to 55% on day 3 and 78% on day 7). The probability of spontaneous closure of the ductus arteriosus keeps increasing until at least 1 week after birth which favors delayed treatment of only those infants that do not show spontaneous closure. Better prediction of the spontaneous closure of the ductus arteriosus in the individual newborn is a key factor to find the optimal management strategy for PDA in preterm infants.
abstract_unstemmed	The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to 55% on day 3 and 78% on day 7). The probability of spontaneous closure of the ductus arteriosus keeps increasing until at least 1 week after birth which favors delayed treatment of only those infants that do not show spontaneous closure. Better prediction of the spontaneous closure of the ductus arteriosus in the individual newborn is a key factor to find the optimal management strategy for PDA in preterm infants.
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title_short	Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review
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