Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response

Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated...
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Gespeichert in:

Autor*in:	Korbinian Bösl [verfasserIn] Miriam Giambelluca [verfasserIn] Markus Haug [verfasserIn] Marit Bugge [verfasserIn] Terje Espevik [verfasserIn] Richard K. Kandasamy [verfasserIn] Bjarte Bergstrøm [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	innate immunity Toll-like receptors Toll-like receptor 2 Toll-like receptor 8 signaling monocytes

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2018.00618

Katalog-ID:	DOAJ051589974

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language	English
source	In Frontiers in Physiology 9(2018) volume:9 year:2018
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topic_facet	innate immunity Toll-like receptors Toll-like receptor 2 Toll-like receptor 8 signaling monocytes Physiology
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container_title	Frontiers in Physiology
authorswithroles_txt_mv	Korbinian Bösl @@aut@@ Miriam Giambelluca @@aut@@ Markus Haug @@aut@@ Marit Bugge @@aut@@ Terje Espevik @@aut@@ Richard K. Kandasamy @@aut@@ Bjarte Bergstrøm @@aut@@
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callnumber-first	Q - Science
author	Korbinian Bösl
spellingShingle	Korbinian Bösl misc QP1-981 misc innate immunity misc Toll-like receptors misc Toll-like receptor 2 misc Toll-like receptor 8 misc signaling misc monocytes misc Physiology Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
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topic_title	QP1-981 Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response innate immunity Toll-like receptors Toll-like receptor 2 Toll-like receptor 8 signaling monocytes
topic	misc QP1-981 misc innate immunity misc Toll-like receptors misc Toll-like receptor 2 misc Toll-like receptor 8 misc signaling misc monocytes misc Physiology
topic_unstemmed	misc QP1-981 misc innate immunity misc Toll-like receptors misc Toll-like receptor 2 misc Toll-like receptor 8 misc signaling misc monocytes misc Physiology
topic_browse	misc QP1-981 misc innate immunity misc Toll-like receptors misc Toll-like receptor 2 misc Toll-like receptor 8 misc signaling misc monocytes misc Physiology
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title	Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
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title_full	Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
author_sort	Korbinian Bösl
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author_browse	Korbinian Bösl Miriam Giambelluca Markus Haug Marit Bugge Terje Espevik Richard K. Kandasamy Bjarte Bergstrøm
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title_sort	coactivation of tlr2 and tlr8 in primary human monocytes triggers a distinct inflammatory signaling response
callnumber	QP1-981
title_auth	Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
abstract	Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through innate receptors such as Toll-like receptors (TLRs). We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human primary monocytes provides a distinct immune activation profile compared to signaling from either TLR alone. We compare gene signatures induced by either stimulus alone or together and show that co-signaling results in downstream differences in regulation of signaling and gene transcription. We demonstrate that these differences result in altered cytokine profiles between single and multi-receptor signaling, and show how it can influence both T-cell and neutrophil responses. The end response is tailored to combat extracellular pathogens, possibly by modifying the regulation of IFNβ and IL12-family cytokines.
abstractGer	Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through innate receptors such as Toll-like receptors (TLRs). We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human primary monocytes provides a distinct immune activation profile compared to signaling from either TLR alone. We compare gene signatures induced by either stimulus alone or together and show that co-signaling results in downstream differences in regulation of signaling and gene transcription. We demonstrate that these differences result in altered cytokine profiles between single and multi-receptor signaling, and show how it can influence both T-cell and neutrophil responses. The end response is tailored to combat extracellular pathogens, possibly by modifying the regulation of IFNβ and IL12-family cytokines.
abstract_unstemmed	Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through innate receptors such as Toll-like receptors (TLRs). We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human primary monocytes provides a distinct immune activation profile compared to signaling from either TLR alone. We compare gene signatures induced by either stimulus alone or together and show that co-signaling results in downstream differences in regulation of signaling and gene transcription. We demonstrate that these differences result in altered cytokine profiles between single and multi-receptor signaling, and show how it can influence both T-cell and neutrophil responses. The end response is tailored to combat extracellular pathogens, possibly by modifying the regulation of IFNβ and IL12-family cytokines.
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title_short	Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
url	https://doi.org/10.3389/fphys.2018.00618 https://doaj.org/article/1f5e66cebcf545df8cbf53d5e4dc88ce https://www.frontiersin.org/article/10.3389/fphys.2018.00618/full https://doaj.org/toc/1664-042X
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author2	Miriam Giambelluca Markus Haug Marit Bugge Terje Espevik Richard K. Kandasamy Bjarte Bergstrøm
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up_date	2024-07-03T21:13:03.717Z
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