Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands

Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sen Lin [verfasserIn] Jia Hou [verfasserIn] Fang Xiang [verfasserIn] Xiaoling Zhang [verfasserIn] Lianqiang Che [verfasserIn] Yan Lin [verfasserIn] Shengyu Xu [verfasserIn] De Wu [verfasserIn] Zhengfeng Fang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Mastitis Reproductive stage Proinflammatory cytokine Fatty acid Rat

Übergeordnetes Werk:	In: Animal Nutrition - KeAi Communications Co., Ltd., 2017, 2(2016), 2, Seite 119-126
Übergeordnetes Werk:	volume:2 ; year:2016 ; number:2 ; pages:119-126

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.aninu.2016.03.008

Katalog-ID:	DOAJ051900254

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allfields	10.1016/j.aninu.2016.03.008 doi (DE-627)DOAJ051900254 (DE-599)DOAJb8f607ff77f94080b5dabf91c1049d17 DE-627 ger DE-627 rakwb eng SF1-1100 Sen Lin verfasserin aut Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands. Mastitis Reproductive stage Proinflammatory cytokine Fatty acid Rat Animal culture Jia Hou verfasserin aut Fang Xiang verfasserin aut Xiaoling Zhang verfasserin aut Lianqiang Che verfasserin aut Yan Lin verfasserin aut Shengyu Xu verfasserin aut De Wu verfasserin aut Zhengfeng Fang verfasserin aut In Animal Nutrition KeAi Communications Co., Ltd., 2017 2(2016), 2, Seite 119-126 (DE-627)835589307 (DE-600)2834745-6 24056545 nnns volume:2 year:2016 number:2 pages:119-126 https://doi.org/10.1016/j.aninu.2016.03.008 kostenfrei https://doaj.org/article/b8f607ff77f94080b5dabf91c1049d17 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405654515300706 kostenfrei https://doaj.org/toc/2405-6545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 2 119-126
spelling	10.1016/j.aninu.2016.03.008 doi (DE-627)DOAJ051900254 (DE-599)DOAJb8f607ff77f94080b5dabf91c1049d17 DE-627 ger DE-627 rakwb eng SF1-1100 Sen Lin verfasserin aut Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands. Mastitis Reproductive stage Proinflammatory cytokine Fatty acid Rat Animal culture Jia Hou verfasserin aut Fang Xiang verfasserin aut Xiaoling Zhang verfasserin aut Lianqiang Che verfasserin aut Yan Lin verfasserin aut Shengyu Xu verfasserin aut De Wu verfasserin aut Zhengfeng Fang verfasserin aut In Animal Nutrition KeAi Communications Co., Ltd., 2017 2(2016), 2, Seite 119-126 (DE-627)835589307 (DE-600)2834745-6 24056545 nnns volume:2 year:2016 number:2 pages:119-126 https://doi.org/10.1016/j.aninu.2016.03.008 kostenfrei https://doaj.org/article/b8f607ff77f94080b5dabf91c1049d17 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405654515300706 kostenfrei https://doaj.org/toc/2405-6545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 2 119-126
allfields_unstemmed	10.1016/j.aninu.2016.03.008 doi (DE-627)DOAJ051900254 (DE-599)DOAJb8f607ff77f94080b5dabf91c1049d17 DE-627 ger DE-627 rakwb eng SF1-1100 Sen Lin verfasserin aut Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands. Mastitis Reproductive stage Proinflammatory cytokine Fatty acid Rat Animal culture Jia Hou verfasserin aut Fang Xiang verfasserin aut Xiaoling Zhang verfasserin aut Lianqiang Che verfasserin aut Yan Lin verfasserin aut Shengyu Xu verfasserin aut De Wu verfasserin aut Zhengfeng Fang verfasserin aut In Animal Nutrition KeAi Communications Co., Ltd., 2017 2(2016), 2, Seite 119-126 (DE-627)835589307 (DE-600)2834745-6 24056545 nnns volume:2 year:2016 number:2 pages:119-126 https://doi.org/10.1016/j.aninu.2016.03.008 kostenfrei https://doaj.org/article/b8f607ff77f94080b5dabf91c1049d17 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405654515300706 kostenfrei https://doaj.org/toc/2405-6545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 2 119-126
allfieldsGer	10.1016/j.aninu.2016.03.008 doi (DE-627)DOAJ051900254 (DE-599)DOAJb8f607ff77f94080b5dabf91c1049d17 DE-627 ger DE-627 rakwb eng SF1-1100 Sen Lin verfasserin aut Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands. Mastitis Reproductive stage Proinflammatory cytokine Fatty acid Rat Animal culture Jia Hou verfasserin aut Fang Xiang verfasserin aut Xiaoling Zhang verfasserin aut Lianqiang Che verfasserin aut Yan Lin verfasserin aut Shengyu Xu verfasserin aut De Wu verfasserin aut Zhengfeng Fang verfasserin aut In Animal Nutrition KeAi Communications Co., Ltd., 2017 2(2016), 2, Seite 119-126 (DE-627)835589307 (DE-600)2834745-6 24056545 nnns volume:2 year:2016 number:2 pages:119-126 https://doi.org/10.1016/j.aninu.2016.03.008 kostenfrei https://doaj.org/article/b8f607ff77f94080b5dabf91c1049d17 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405654515300706 kostenfrei https://doaj.org/toc/2405-6545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 2 119-126
allfieldsSound	10.1016/j.aninu.2016.03.008 doi (DE-627)DOAJ051900254 (DE-599)DOAJb8f607ff77f94080b5dabf91c1049d17 DE-627 ger DE-627 rakwb eng SF1-1100 Sen Lin verfasserin aut Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands. Mastitis Reproductive stage Proinflammatory cytokine Fatty acid Rat Animal culture Jia Hou verfasserin aut Fang Xiang verfasserin aut Xiaoling Zhang verfasserin aut Lianqiang Che verfasserin aut Yan Lin verfasserin aut Shengyu Xu verfasserin aut De Wu verfasserin aut Zhengfeng Fang verfasserin aut In Animal Nutrition KeAi Communications Co., Ltd., 2017 2(2016), 2, Seite 119-126 (DE-627)835589307 (DE-600)2834745-6 24056545 nnns volume:2 year:2016 number:2 pages:119-126 https://doi.org/10.1016/j.aninu.2016.03.008 kostenfrei https://doaj.org/article/b8f607ff77f94080b5dabf91c1049d17 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405654515300706 kostenfrei https://doaj.org/toc/2405-6545 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 2 2016 2 119-126
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source	In Animal Nutrition 2(2016), 2, Seite 119-126 volume:2 year:2016 number:2 pages:119-126
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authorswithroles_txt_mv	Sen Lin @@aut@@ Jia Hou @@aut@@ Fang Xiang @@aut@@ Xiaoling Zhang @@aut@@ Lianqiang Che @@aut@@ Yan Lin @@aut@@ Shengyu Xu @@aut@@ De Wu @@aut@@ Zhengfeng Fang @@aut@@
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topic_title	SF1-1100 Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands Mastitis Reproductive stage Proinflammatory cytokine Fatty acid Rat
topic	misc SF1-1100 misc Mastitis misc Reproductive stage misc Proinflammatory cytokine misc Fatty acid misc Rat misc Animal culture
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title	Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands
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title_full	Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands
author_sort	Sen Lin
journal	Animal Nutrition
journalStr	Animal Nutrition
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author_browse	Sen Lin Jia Hou Fang Xiang Xiaoling Zhang Lianqiang Che Yan Lin Shengyu Xu De Wu Zhengfeng Fang
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doi_str_mv	10.1016/j.aninu.2016.03.008
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title_sort	reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands
callnumber	SF1-1100
title_auth	Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands
abstract	Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands.
abstractGer	Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands.
abstract_unstemmed	Mastitis is a common disease for mammals all around the world. Figuring out why mastitis mainly occurs around parturition may be helpful for dealing with the disease. Lipolytic activity and oxidative stress take place around parturition, which may leads to alteration in fatty acids profile and proinflammatory cytokine expression. Thus, the aim of the present study was to further our understanding about the high incidence of mastitis around parturition by comparison of plasma fatty acid profile and mammary inflammation indicators at different reproductive stages. A total of 47 female rats were included in the present study. After mating, all the pregnant and non-pregnant rats began to receive the same experimental diet. Blood samples were collected at day 1 and 14 of gestation as well as day 3 postpartum. Mammary samples were collected at day 14 of gestation and day 3 postpartum from pregnant and non-pregnant rats. The results showed that rats at d 3 postpartum had greater (P < 0.05) plasma concentrations of non-esterified fatty acids (NEFA), arachidonic acid (ARA) and docosahexaenoic acid (DHA) as well as ARA: eicosapentaenoic acid (EPA) ratio than those at d 14 of gestation. The mRNA abundances of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-8 and xanthine oxidoreductase (XOR) in mammary of the pregnant rats were greater (P < 0.05) than those in age-matched non-pregnant rats. Rats at d 3 postpartum had higher (P < 0.05) protein expression levels of IL-1β and TNF-α as well as meloperoxidase (MPO) activity and polymorphonuclear neutrophils (PMN) prevalence than those at d 1 of gestation. The rats at d 3 postpartum also had greater (P < 0.05) IL-1β and MPO activity than those at d 14 of gestation. The results indicated that elevated mammary expression of proinflammatory cytokines and XOR as well as altered fatty acid profile around parturition might facilitate the recruitment of neutrophils into mammary glands.
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container_issue	2
title_short	Reproductive stage associated changes in plasma fatty acid profile and proinflammatory cytokine expression in rat mammary glands
url	https://doi.org/10.1016/j.aninu.2016.03.008 https://doaj.org/article/b8f607ff77f94080b5dabf91c1049d17 http://www.sciencedirect.com/science/article/pii/S2405654515300706 https://doaj.org/toc/2405-6545
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author2	Jia Hou Fang Xiang Xiaoling Zhang Lianqiang Che Yan Lin Shengyu Xu De Wu Zhengfeng Fang
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up_date	2024-07-03T22:49:14.731Z
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