Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves

Motor nerves and sensory nerves conduct signals in different directions and function in different ways. In the surgical treatment of peripheral nerve injuries, the best prognosis is obtained by keeping the motor and sensory nerves separated and repairing the nerves using the suture method. However,...
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Autor*in:	Xiu-xiu Zhang [verfasserIn] Yu-hui Kou [verfasserIn] Xiao-feng Yin [verfasserIn] Bao-guo Jiang [verfasserIn] Pei-xun Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	nerve regeneration; nerve remodeling; peripheral nerve; acetylcholinesterase staining; muscle denervation; neural anastomosis; nerve conduit; neural regeneration

Übergeordnetes Werk:	In: Neural Regeneration Research - Wolters Kluwer Medknow Publications, 2014, 12(2017), 7, Seite 1172-1176
Übergeordnetes Werk:	volume:12 ; year:2017 ; number:7 ; pages:1172-1176

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/1673-5374.211199

Katalog-ID:	DOAJ052169537

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authorswithroles_txt_mv	Xiu-xiu Zhang @@aut@@ Yu-hui Kou @@aut@@ Xiao-feng Yin @@aut@@ Bao-guo Jiang @@aut@@ Pei-xun Zhang @@aut@@
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callnumber-first	R - Medicine
author	Xiu-xiu Zhang
spellingShingle	Xiu-xiu Zhang misc RC346-429 misc nerve regeneration; nerve remodeling; peripheral nerve; acetylcholinesterase staining; muscle denervation; neural anastomosis; nerve conduit; neural regeneration misc Neurology. Diseases of the nervous system Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves
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topic_title	RC346-429 Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves nerve regeneration; nerve remodeling; peripheral nerve; acetylcholinesterase staining; muscle denervation; neural anastomosis; nerve conduit; neural regeneration
topic	misc RC346-429 misc nerve regeneration; nerve remodeling; peripheral nerve; acetylcholinesterase staining; muscle denervation; neural anastomosis; nerve conduit; neural regeneration misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc nerve regeneration; nerve remodeling; peripheral nerve; acetylcholinesterase staining; muscle denervation; neural anastomosis; nerve conduit; neural regeneration misc Neurology. Diseases of the nervous system
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title	Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves
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title_full	Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves
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title_sort	short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves
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title_auth	Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves
abstract	Motor nerves and sensory nerves conduct signals in different directions and function in different ways. In the surgical treatment of peripheral nerve injuries, the best prognosis is obtained by keeping the motor and sensory nerves separated and repairing the nerves using the suture method. However, the clinical consequences of connections between sensory and motor nerves currently remain unknown. In this study, we analyzed the anatomical structure of the rat femoral nerve, and observed the motor and sensory branches of the femoral nerve in the quadriceps femoris. After ligation of the nerves, the proximal end of the sensory nerve was connected with the distal end of the motor nerve, followed by observation of the changes in the newly-formed regenerated nerve fibers. Acetylcholinesterase staining was used to distinguish between the myelinated and unmyelinated motor and sensory nerves. Denervated muscle and newly formed nerves were compared in terms of morphology, electrophysiology and histochemistry. At 8 weeks after connection, no motor nerve fibers were observed on either side of the nerve conduit and the number of nerve fibers increased at the proximal end. The proportion of newly-formed motor and sensory fibers was different on both sides of the conduit. The area occupied by autonomic nerves in the proximal regenerative nerve was limited, but no distinct myelin sheath was visible in the distal nerve. These results confirm that sensory and motor nerves cannot be effectively connected. Moreover, the change of target organ at the distal end affects the type of nerves at the proximal end.
abstractGer	Motor nerves and sensory nerves conduct signals in different directions and function in different ways. In the surgical treatment of peripheral nerve injuries, the best prognosis is obtained by keeping the motor and sensory nerves separated and repairing the nerves using the suture method. However, the clinical consequences of connections between sensory and motor nerves currently remain unknown. In this study, we analyzed the anatomical structure of the rat femoral nerve, and observed the motor and sensory branches of the femoral nerve in the quadriceps femoris. After ligation of the nerves, the proximal end of the sensory nerve was connected with the distal end of the motor nerve, followed by observation of the changes in the newly-formed regenerated nerve fibers. Acetylcholinesterase staining was used to distinguish between the myelinated and unmyelinated motor and sensory nerves. Denervated muscle and newly formed nerves were compared in terms of morphology, electrophysiology and histochemistry. At 8 weeks after connection, no motor nerve fibers were observed on either side of the nerve conduit and the number of nerve fibers increased at the proximal end. The proportion of newly-formed motor and sensory fibers was different on both sides of the conduit. The area occupied by autonomic nerves in the proximal regenerative nerve was limited, but no distinct myelin sheath was visible in the distal nerve. These results confirm that sensory and motor nerves cannot be effectively connected. Moreover, the change of target organ at the distal end affects the type of nerves at the proximal end.
abstract_unstemmed	Motor nerves and sensory nerves conduct signals in different directions and function in different ways. In the surgical treatment of peripheral nerve injuries, the best prognosis is obtained by keeping the motor and sensory nerves separated and repairing the nerves using the suture method. However, the clinical consequences of connections between sensory and motor nerves currently remain unknown. In this study, we analyzed the anatomical structure of the rat femoral nerve, and observed the motor and sensory branches of the femoral nerve in the quadriceps femoris. After ligation of the nerves, the proximal end of the sensory nerve was connected with the distal end of the motor nerve, followed by observation of the changes in the newly-formed regenerated nerve fibers. Acetylcholinesterase staining was used to distinguish between the myelinated and unmyelinated motor and sensory nerves. Denervated muscle and newly formed nerves were compared in terms of morphology, electrophysiology and histochemistry. At 8 weeks after connection, no motor nerve fibers were observed on either side of the nerve conduit and the number of nerve fibers increased at the proximal end. The proportion of newly-formed motor and sensory fibers was different on both sides of the conduit. The area occupied by autonomic nerves in the proximal regenerative nerve was limited, but no distinct myelin sheath was visible in the distal nerve. These results confirm that sensory and motor nerves cannot be effectively connected. Moreover, the change of target organ at the distal end affects the type of nerves at the proximal end.
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title_short	Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves
url	https://doi.org/10.4103/1673-5374.211199 https://doaj.org/article/6bd32a3bf448480fb2dc31f9efa22ffd http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1172;epage=1176;aulast=Zhang https://doaj.org/toc/1673-5374
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author2	Yu-hui Kou Xiao-feng Yin Bao-guo Jiang Pei-xun Zhang
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up_date	2024-07-04T00:00:39.286Z
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At 8 weeks after connection, no motor nerve fibers were observed on either side of the nerve conduit and the number of nerve fibers increased at the proximal end. The proportion of newly-formed motor and sensory fibers was different on both sides of the conduit. The area occupied by autonomic nerves in the proximal regenerative nerve was limited, but no distinct myelin sheath was visible in the distal nerve. These results confirm that sensory and motor nerves cannot be effectively connected. Moreover, the change of target organ at the distal end affects the type of nerves at the proximal end.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nerve regeneration; nerve remodeling; peripheral nerve; acetylcholinesterase staining; muscle denervation; neural anastomosis; nerve conduit; neural regeneration</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurology. 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Short-term observations of the regenerative potential of injured proximal sensory nerves crossed with distal motor nerves

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