Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was...
Ausführliche Beschreibung
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| Autor*in: |
Fengju Chen [verfasserIn] Yiqun Zhang [verfasserIn] Yasin Şenbabaoğlu [verfasserIn] Giovanni Ciriello [verfasserIn] Lixing Yang [verfasserIn] Ed Reznik [verfasserIn] Brian Shuch [verfasserIn] Goran Micevic [verfasserIn] Guillermo De Velasco [verfasserIn] Eve Shinbrot [verfasserIn] Michael S. Noble [verfasserIn] Yiling Lu [verfasserIn] Kyle R. Covington [verfasserIn] Liu Xi [verfasserIn] Jennifer A. Drummond [verfasserIn] Donna Muzny [verfasserIn] Hyojin Kang [verfasserIn] Junehawk Lee [verfasserIn] Pheroze Tamboli [verfasserIn] Victor Reuter [verfasserIn] Carl Simon Shelley [verfasserIn] Benny A. Kaipparettu [verfasserIn] Donald P. Bottaro [verfasserIn] Andrew K. Godwin [verfasserIn] Richard A. Gibbs [verfasserIn] Gad Getz [verfasserIn] Raju Kucherlapati [verfasserIn] Peter J. Park [verfasserIn] Chris Sander [verfasserIn] Elizabeth P. Henske [verfasserIn] Jane H. Zhou [verfasserIn] David J. Kwiatkowski [verfasserIn] Thai H. Ho [verfasserIn] Toni K. Choueiri [verfasserIn] James J. Hsieh [verfasserIn] Rehan Akbani [verfasserIn] Gordon B. Mills [verfasserIn] A. Ari Hakimi [verfasserIn] David A. Wheeler [verfasserIn] Chad J. Creighton [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Übergeordnetes Werk: |
In: Cell Reports - Elsevier, 2015, 14(2016), 10, Seite 2476-2489 |
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| Übergeordnetes Werk: |
volume:14 ; year:2016 ; number:10 ; pages:2476-2489 |
| Links: |
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| DOI / URN: |
10.1016/j.celrep.2016.02.024 |
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| Katalog-ID: |
DOAJ052177815 |
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| 520 | |a On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. | ||
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| 700 | 0 | |a Yasin Şenbabaoğlu |e verfasserin |4 aut | |
| 700 | 0 | |a Giovanni Ciriello |e verfasserin |4 aut | |
| 700 | 0 | |a Lixing Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Ed Reznik |e verfasserin |4 aut | |
| 700 | 0 | |a Brian Shuch |e verfasserin |4 aut | |
| 700 | 0 | |a Goran Micevic |e verfasserin |4 aut | |
| 700 | 0 | |a Guillermo De Velasco |e verfasserin |4 aut | |
| 700 | 0 | |a Eve Shinbrot |e verfasserin |4 aut | |
| 700 | 0 | |a Michael S. Noble |e verfasserin |4 aut | |
| 700 | 0 | |a Yiling Lu |e verfasserin |4 aut | |
| 700 | 0 | |a Kyle R. Covington |e verfasserin |4 aut | |
| 700 | 0 | |a Liu Xi |e verfasserin |4 aut | |
| 700 | 0 | |a Jennifer A. Drummond |e verfasserin |4 aut | |
| 700 | 0 | |a Donna Muzny |e verfasserin |4 aut | |
| 700 | 0 | |a Hyojin Kang |e verfasserin |4 aut | |
| 700 | 0 | |a Junehawk Lee |e verfasserin |4 aut | |
| 700 | 0 | |a Pheroze Tamboli |e verfasserin |4 aut | |
| 700 | 0 | |a Victor Reuter |e verfasserin |4 aut | |
| 700 | 0 | |a Carl Simon Shelley |e verfasserin |4 aut | |
| 700 | 0 | |a Benny A. Kaipparettu |e verfasserin |4 aut | |
| 700 | 0 | |a Donald P. Bottaro |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew K. Godwin |e verfasserin |4 aut | |
| 700 | 0 | |a Richard A. Gibbs |e verfasserin |4 aut | |
| 700 | 0 | |a Gad Getz |e verfasserin |4 aut | |
| 700 | 0 | |a Raju Kucherlapati |e verfasserin |4 aut | |
| 700 | 0 | |a Peter J. Park |e verfasserin |4 aut | |
| 700 | 0 | |a Chris Sander |e verfasserin |4 aut | |
| 700 | 0 | |a Elizabeth P. Henske |e verfasserin |4 aut | |
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| 700 | 0 | |a David A. Wheeler |e verfasserin |4 aut | |
| 700 | 0 | |a Chad J. Creighton |e verfasserin |4 aut | |
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10.1016/j.celrep.2016.02.024 doi (DE-627)DOAJ052177815 (DE-599)DOAJ4a90ea0a0d7349be93c5dc15ad373d6c DE-627 ger DE-627 rakwb eng QH301-705.5 Fengju Chen verfasserin aut Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. Biology (General) Yiqun Zhang verfasserin aut Yasin Şenbabaoğlu verfasserin aut Giovanni Ciriello verfasserin aut Lixing Yang verfasserin aut Ed Reznik verfasserin aut Brian Shuch verfasserin aut Goran Micevic verfasserin aut Guillermo De Velasco verfasserin aut Eve Shinbrot verfasserin aut Michael S. Noble verfasserin aut Yiling Lu verfasserin aut Kyle R. Covington verfasserin aut Liu Xi verfasserin aut Jennifer A. Drummond verfasserin aut Donna Muzny verfasserin aut Hyojin Kang verfasserin aut Junehawk Lee verfasserin aut Pheroze Tamboli verfasserin aut Victor Reuter verfasserin aut Carl Simon Shelley verfasserin aut Benny A. Kaipparettu verfasserin aut Donald P. Bottaro verfasserin aut Andrew K. Godwin verfasserin aut Richard A. Gibbs verfasserin aut Gad Getz verfasserin aut Raju Kucherlapati verfasserin aut Peter J. Park verfasserin aut Chris Sander verfasserin aut Elizabeth P. Henske verfasserin aut Jane H. Zhou verfasserin aut David J. Kwiatkowski verfasserin aut Thai H. Ho verfasserin aut Toni K. Choueiri verfasserin aut James J. Hsieh verfasserin aut Rehan Akbani verfasserin aut Gordon B. Mills verfasserin aut A. Ari Hakimi verfasserin aut David A. Wheeler verfasserin aut Chad J. Creighton verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 10, Seite 2476-2489 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:10 pages:2476-2489 https://doi.org/10.1016/j.celrep.2016.02.024 kostenfrei https://doaj.org/article/4a90ea0a0d7349be93c5dc15ad373d6c kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124716301279 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 10 2476-2489 |
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10.1016/j.celrep.2016.02.024 doi (DE-627)DOAJ052177815 (DE-599)DOAJ4a90ea0a0d7349be93c5dc15ad373d6c DE-627 ger DE-627 rakwb eng QH301-705.5 Fengju Chen verfasserin aut Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. Biology (General) Yiqun Zhang verfasserin aut Yasin Şenbabaoğlu verfasserin aut Giovanni Ciriello verfasserin aut Lixing Yang verfasserin aut Ed Reznik verfasserin aut Brian Shuch verfasserin aut Goran Micevic verfasserin aut Guillermo De Velasco verfasserin aut Eve Shinbrot verfasserin aut Michael S. Noble verfasserin aut Yiling Lu verfasserin aut Kyle R. Covington verfasserin aut Liu Xi verfasserin aut Jennifer A. Drummond verfasserin aut Donna Muzny verfasserin aut Hyojin Kang verfasserin aut Junehawk Lee verfasserin aut Pheroze Tamboli verfasserin aut Victor Reuter verfasserin aut Carl Simon Shelley verfasserin aut Benny A. Kaipparettu verfasserin aut Donald P. Bottaro verfasserin aut Andrew K. Godwin verfasserin aut Richard A. Gibbs verfasserin aut Gad Getz verfasserin aut Raju Kucherlapati verfasserin aut Peter J. Park verfasserin aut Chris Sander verfasserin aut Elizabeth P. Henske verfasserin aut Jane H. Zhou verfasserin aut David J. Kwiatkowski verfasserin aut Thai H. Ho verfasserin aut Toni K. Choueiri verfasserin aut James J. Hsieh verfasserin aut Rehan Akbani verfasserin aut Gordon B. Mills verfasserin aut A. Ari Hakimi verfasserin aut David A. Wheeler verfasserin aut Chad J. Creighton verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 10, Seite 2476-2489 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:10 pages:2476-2489 https://doi.org/10.1016/j.celrep.2016.02.024 kostenfrei https://doaj.org/article/4a90ea0a0d7349be93c5dc15ad373d6c kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124716301279 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 10 2476-2489 |
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10.1016/j.celrep.2016.02.024 doi (DE-627)DOAJ052177815 (DE-599)DOAJ4a90ea0a0d7349be93c5dc15ad373d6c DE-627 ger DE-627 rakwb eng QH301-705.5 Fengju Chen verfasserin aut Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. Biology (General) Yiqun Zhang verfasserin aut Yasin Şenbabaoğlu verfasserin aut Giovanni Ciriello verfasserin aut Lixing Yang verfasserin aut Ed Reznik verfasserin aut Brian Shuch verfasserin aut Goran Micevic verfasserin aut Guillermo De Velasco verfasserin aut Eve Shinbrot verfasserin aut Michael S. Noble verfasserin aut Yiling Lu verfasserin aut Kyle R. Covington verfasserin aut Liu Xi verfasserin aut Jennifer A. Drummond verfasserin aut Donna Muzny verfasserin aut Hyojin Kang verfasserin aut Junehawk Lee verfasserin aut Pheroze Tamboli verfasserin aut Victor Reuter verfasserin aut Carl Simon Shelley verfasserin aut Benny A. Kaipparettu verfasserin aut Donald P. Bottaro verfasserin aut Andrew K. Godwin verfasserin aut Richard A. Gibbs verfasserin aut Gad Getz verfasserin aut Raju Kucherlapati verfasserin aut Peter J. Park verfasserin aut Chris Sander verfasserin aut Elizabeth P. Henske verfasserin aut Jane H. Zhou verfasserin aut David J. Kwiatkowski verfasserin aut Thai H. Ho verfasserin aut Toni K. Choueiri verfasserin aut James J. Hsieh verfasserin aut Rehan Akbani verfasserin aut Gordon B. Mills verfasserin aut A. Ari Hakimi verfasserin aut David A. Wheeler verfasserin aut Chad J. Creighton verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 10, Seite 2476-2489 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:10 pages:2476-2489 https://doi.org/10.1016/j.celrep.2016.02.024 kostenfrei https://doaj.org/article/4a90ea0a0d7349be93c5dc15ad373d6c kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124716301279 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 10 2476-2489 |
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10.1016/j.celrep.2016.02.024 doi (DE-627)DOAJ052177815 (DE-599)DOAJ4a90ea0a0d7349be93c5dc15ad373d6c DE-627 ger DE-627 rakwb eng QH301-705.5 Fengju Chen verfasserin aut Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. Biology (General) Yiqun Zhang verfasserin aut Yasin Şenbabaoğlu verfasserin aut Giovanni Ciriello verfasserin aut Lixing Yang verfasserin aut Ed Reznik verfasserin aut Brian Shuch verfasserin aut Goran Micevic verfasserin aut Guillermo De Velasco verfasserin aut Eve Shinbrot verfasserin aut Michael S. Noble verfasserin aut Yiling Lu verfasserin aut Kyle R. Covington verfasserin aut Liu Xi verfasserin aut Jennifer A. Drummond verfasserin aut Donna Muzny verfasserin aut Hyojin Kang verfasserin aut Junehawk Lee verfasserin aut Pheroze Tamboli verfasserin aut Victor Reuter verfasserin aut Carl Simon Shelley verfasserin aut Benny A. Kaipparettu verfasserin aut Donald P. Bottaro verfasserin aut Andrew K. Godwin verfasserin aut Richard A. Gibbs verfasserin aut Gad Getz verfasserin aut Raju Kucherlapati verfasserin aut Peter J. Park verfasserin aut Chris Sander verfasserin aut Elizabeth P. Henske verfasserin aut Jane H. Zhou verfasserin aut David J. Kwiatkowski verfasserin aut Thai H. Ho verfasserin aut Toni K. Choueiri verfasserin aut James J. Hsieh verfasserin aut Rehan Akbani verfasserin aut Gordon B. Mills verfasserin aut A. Ari Hakimi verfasserin aut David A. Wheeler verfasserin aut Chad J. Creighton verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 10, Seite 2476-2489 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:10 pages:2476-2489 https://doi.org/10.1016/j.celrep.2016.02.024 kostenfrei https://doaj.org/article/4a90ea0a0d7349be93c5dc15ad373d6c kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124716301279 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 10 2476-2489 |
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10.1016/j.celrep.2016.02.024 doi (DE-627)DOAJ052177815 (DE-599)DOAJ4a90ea0a0d7349be93c5dc15ad373d6c DE-627 ger DE-627 rakwb eng QH301-705.5 Fengju Chen verfasserin aut Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. Biology (General) Yiqun Zhang verfasserin aut Yasin Şenbabaoğlu verfasserin aut Giovanni Ciriello verfasserin aut Lixing Yang verfasserin aut Ed Reznik verfasserin aut Brian Shuch verfasserin aut Goran Micevic verfasserin aut Guillermo De Velasco verfasserin aut Eve Shinbrot verfasserin aut Michael S. Noble verfasserin aut Yiling Lu verfasserin aut Kyle R. Covington verfasserin aut Liu Xi verfasserin aut Jennifer A. Drummond verfasserin aut Donna Muzny verfasserin aut Hyojin Kang verfasserin aut Junehawk Lee verfasserin aut Pheroze Tamboli verfasserin aut Victor Reuter verfasserin aut Carl Simon Shelley verfasserin aut Benny A. Kaipparettu verfasserin aut Donald P. Bottaro verfasserin aut Andrew K. Godwin verfasserin aut Richard A. Gibbs verfasserin aut Gad Getz verfasserin aut Raju Kucherlapati verfasserin aut Peter J. Park verfasserin aut Chris Sander verfasserin aut Elizabeth P. Henske verfasserin aut Jane H. Zhou verfasserin aut David J. Kwiatkowski verfasserin aut Thai H. Ho verfasserin aut Toni K. Choueiri verfasserin aut James J. Hsieh verfasserin aut Rehan Akbani verfasserin aut Gordon B. Mills verfasserin aut A. Ari Hakimi verfasserin aut David A. Wheeler verfasserin aut Chad J. Creighton verfasserin aut In Cell Reports Elsevier, 2015 14(2016), 10, Seite 2476-2489 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:14 year:2016 number:10 pages:2476-2489 https://doi.org/10.1016/j.celrep.2016.02.024 kostenfrei https://doaj.org/article/4a90ea0a0d7349be93c5dc15ad373d6c kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124716301279 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 14 2016 10 2476-2489 |
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Fengju Chen @@aut@@ Yiqun Zhang @@aut@@ Yasin Şenbabaoğlu @@aut@@ Giovanni Ciriello @@aut@@ Lixing Yang @@aut@@ Ed Reznik @@aut@@ Brian Shuch @@aut@@ Goran Micevic @@aut@@ Guillermo De Velasco @@aut@@ Eve Shinbrot @@aut@@ Michael S. Noble @@aut@@ Yiling Lu @@aut@@ Kyle R. Covington @@aut@@ Liu Xi @@aut@@ Jennifer A. Drummond @@aut@@ Donna Muzny @@aut@@ Hyojin Kang @@aut@@ Junehawk Lee @@aut@@ Pheroze Tamboli @@aut@@ Victor Reuter @@aut@@ Carl Simon Shelley @@aut@@ Benny A. Kaipparettu @@aut@@ Donald P. Bottaro @@aut@@ Andrew K. Godwin @@aut@@ Richard A. Gibbs @@aut@@ Gad Getz @@aut@@ Raju Kucherlapati @@aut@@ Peter J. Park @@aut@@ Chris Sander @@aut@@ Elizabeth P. Henske @@aut@@ Jane H. Zhou @@aut@@ David J. Kwiatkowski @@aut@@ Thai H. Ho @@aut@@ Toni K. Choueiri @@aut@@ James J. Hsieh @@aut@@ Rehan Akbani @@aut@@ Gordon B. Mills @@aut@@ A. Ari Hakimi @@aut@@ David A. Wheeler @@aut@@ Chad J. Creighton @@aut@@ |
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Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma |
| abstract |
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. |
| abstractGer |
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. |
| abstract_unstemmed |
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. |
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| container_issue |
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| title_short |
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma |
| url |
https://doi.org/10.1016/j.celrep.2016.02.024 https://doaj.org/article/4a90ea0a0d7349be93c5dc15ad373d6c http://www.sciencedirect.com/science/article/pii/S2211124716301279 https://doaj.org/toc/2211-1247 |
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true |
| author2 |
Yiqun Zhang Yasin Şenbabaoğlu Giovanni Ciriello Lixing Yang Ed Reznik Brian Shuch Goran Micevic Guillermo De Velasco Eve Shinbrot Michael S. Noble Yiling Lu Kyle R. Covington Liu Xi Jennifer A. Drummond Donna Muzny Hyojin Kang Junehawk Lee Pheroze Tamboli Victor Reuter Carl Simon Shelley Benny A. Kaipparettu Donald P. Bottaro Andrew K. Godwin Richard A. Gibbs Gad Getz Raju Kucherlapati Peter J. Park Chris Sander Elizabeth P. Henske Jane H. Zhou David J. Kwiatkowski Thai H. Ho Toni K. Choueiri James J. Hsieh Rehan Akbani Gordon B. Mills A. Ari Hakimi David A. Wheeler Chad J. Creighton |
| author2Str |
Yiqun Zhang Yasin Şenbabaoğlu Giovanni Ciriello Lixing Yang Ed Reznik Brian Shuch Goran Micevic Guillermo De Velasco Eve Shinbrot Michael S. Noble Yiling Lu Kyle R. Covington Liu Xi Jennifer A. Drummond Donna Muzny Hyojin Kang Junehawk Lee Pheroze Tamboli Victor Reuter Carl Simon Shelley Benny A. Kaipparettu Donald P. Bottaro Andrew K. Godwin Richard A. Gibbs Gad Getz Raju Kucherlapati Peter J. Park Chris Sander Elizabeth P. Henske Jane H. Zhou David J. Kwiatkowski Thai H. Ho Toni K. Choueiri James J. Hsieh Rehan Akbani Gordon B. Mills A. Ari Hakimi David A. Wheeler Chad J. Creighton |
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| doi_str |
10.1016/j.celrep.2016.02.024 |
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| up_date |
2024-07-04T00:02:39.450Z |
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| score |
7.3996153 |