p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and inv...
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Autor*in:	Talha Anwar [verfasserIn] Caroline Arellano-Garcia [verfasserIn] James Ropa [verfasserIn] Yu-Chih Chen [verfasserIn] Hong Sun Kim [verfasserIn] Euisik Yoon [verfasserIn] Sierrah Grigsby [verfasserIn] Venkatesha Basrur [verfasserIn] Alexey I. Nesvizhskii [verfasserIn] Andrew Muntean [verfasserIn] Maria E. Gonzalez [verfasserIn] Kelley M. Kidwell [verfasserIn] Zaneta Nikolovska-Coleska [verfasserIn] Celina G. Kleer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 13
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-05078-8

Katalog-ID:	DOAJ052246329

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Indexfelder

author_variant	t a ta c a g cag j r jr y c c ycc h s k hsk e y ey s g sg v b vb a i n ain a m am m e g meg k m k kmk z n c znc c g k cgk
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allfields	10.1038/s41467-018-05078-8 doi (DE-627)DOAJ052246329 (DE-599)DOAJ293a4b7d30a541e885aa00f3154a9581 DE-627 ger DE-627 rakwb eng Talha Anwar verfasserin aut p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion. Science Q Caroline Arellano-Garcia verfasserin aut James Ropa verfasserin aut Yu-Chih Chen verfasserin aut Hong Sun Kim verfasserin aut Euisik Yoon verfasserin aut Sierrah Grigsby verfasserin aut Venkatesha Basrur verfasserin aut Alexey I. Nesvizhskii verfasserin aut Andrew Muntean verfasserin aut Maria E. Gonzalez verfasserin aut Kelley M. Kidwell verfasserin aut Zaneta Nikolovska-Coleska verfasserin aut Celina G. Kleer verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 13 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:13 https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581 kostenfrei https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 13
spelling	10.1038/s41467-018-05078-8 doi (DE-627)DOAJ052246329 (DE-599)DOAJ293a4b7d30a541e885aa00f3154a9581 DE-627 ger DE-627 rakwb eng Talha Anwar verfasserin aut p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion. Science Q Caroline Arellano-Garcia verfasserin aut James Ropa verfasserin aut Yu-Chih Chen verfasserin aut Hong Sun Kim verfasserin aut Euisik Yoon verfasserin aut Sierrah Grigsby verfasserin aut Venkatesha Basrur verfasserin aut Alexey I. Nesvizhskii verfasserin aut Andrew Muntean verfasserin aut Maria E. Gonzalez verfasserin aut Kelley M. Kidwell verfasserin aut Zaneta Nikolovska-Coleska verfasserin aut Celina G. Kleer verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 13 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:13 https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581 kostenfrei https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 13
allfields_unstemmed	10.1038/s41467-018-05078-8 doi (DE-627)DOAJ052246329 (DE-599)DOAJ293a4b7d30a541e885aa00f3154a9581 DE-627 ger DE-627 rakwb eng Talha Anwar verfasserin aut p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion. Science Q Caroline Arellano-Garcia verfasserin aut James Ropa verfasserin aut Yu-Chih Chen verfasserin aut Hong Sun Kim verfasserin aut Euisik Yoon verfasserin aut Sierrah Grigsby verfasserin aut Venkatesha Basrur verfasserin aut Alexey I. Nesvizhskii verfasserin aut Andrew Muntean verfasserin aut Maria E. Gonzalez verfasserin aut Kelley M. Kidwell verfasserin aut Zaneta Nikolovska-Coleska verfasserin aut Celina G. Kleer verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 13 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:13 https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581 kostenfrei https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 13
allfieldsGer	10.1038/s41467-018-05078-8 doi (DE-627)DOAJ052246329 (DE-599)DOAJ293a4b7d30a541e885aa00f3154a9581 DE-627 ger DE-627 rakwb eng Talha Anwar verfasserin aut p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion. Science Q Caroline Arellano-Garcia verfasserin aut James Ropa verfasserin aut Yu-Chih Chen verfasserin aut Hong Sun Kim verfasserin aut Euisik Yoon verfasserin aut Sierrah Grigsby verfasserin aut Venkatesha Basrur verfasserin aut Alexey I. Nesvizhskii verfasserin aut Andrew Muntean verfasserin aut Maria E. Gonzalez verfasserin aut Kelley M. Kidwell verfasserin aut Zaneta Nikolovska-Coleska verfasserin aut Celina G. Kleer verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 13 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:13 https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581 kostenfrei https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 13
allfieldsSound	10.1038/s41467-018-05078-8 doi (DE-627)DOAJ052246329 (DE-599)DOAJ293a4b7d30a541e885aa00f3154a9581 DE-627 ger DE-627 rakwb eng Talha Anwar verfasserin aut p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion. Science Q Caroline Arellano-Garcia verfasserin aut James Ropa verfasserin aut Yu-Chih Chen verfasserin aut Hong Sun Kim verfasserin aut Euisik Yoon verfasserin aut Sierrah Grigsby verfasserin aut Venkatesha Basrur verfasserin aut Alexey I. Nesvizhskii verfasserin aut Andrew Muntean verfasserin aut Maria E. Gonzalez verfasserin aut Kelley M. Kidwell verfasserin aut Zaneta Nikolovska-Coleska verfasserin aut Celina G. Kleer verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 13 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:13 https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581 kostenfrei https://doi.org/10.1038/s41467-018-05078-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 13
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author	Talha Anwar
spellingShingle	Talha Anwar misc Science misc Q p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
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topic_title	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
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title	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
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title_full	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
author_sort	Talha Anwar
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author_browse	Talha Anwar Caroline Arellano-Garcia James Ropa Yu-Chih Chen Hong Sun Kim Euisik Yoon Sierrah Grigsby Venkatesha Basrur Alexey I. Nesvizhskii Andrew Muntean Maria E. Gonzalez Kelley M. Kidwell Zaneta Nikolovska-Coleska Celina G. Kleer
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title_sort	p38-mediated phosphorylation at t367 induces ezh2 cytoplasmic localization to promote breast cancer metastasis
title_auth	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
abstract	Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion.
abstractGer	Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion.
abstract_unstemmed	Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion.
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title_short	p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
url	https://doi.org/10.1038/s41467-018-05078-8 https://doaj.org/article/293a4b7d30a541e885aa00f3154a9581 https://doaj.org/toc/2041-1723
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author2	Caroline Arellano-Garcia James Ropa Yu-Chih Chen Hong Sun Kim Euisik Yoon Sierrah Grigsby Venkatesha Basrur Alexey I. Nesvizhskii Andrew Muntean Maria E. Gonzalez Kelley M. Kidwell Zaneta Nikolovska-Coleska Celina G. Kleer
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up_date	2024-07-04T00:18:57.515Z
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