NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, an...
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Autor*in:	Seungyong Lee [verfasserIn] Charles Hwang [verfasserIn] Simone Marini [verfasserIn] Robert J. Tower [verfasserIn] Qizhi Qin [verfasserIn] Stefano Negri [verfasserIn] Chase A. Pagani [verfasserIn] Yuxiao Sun [verfasserIn] David M. Stepien [verfasserIn] Michael Sorkin [verfasserIn] Carrie A. Kubiak [verfasserIn] Noelle D. Visser [verfasserIn] Carolyn A. Meyers [verfasserIn] Yiyun Wang [verfasserIn] Husain A. Rasheed [verfasserIn] Jiajia Xu [verfasserIn] Sarah Miller [verfasserIn] Amanda K. Huber [verfasserIn] Liliana Minichiello [verfasserIn] Paul S. Cederna [verfasserIn] Stephen W. P. Kemp [verfasserIn] Thomas L. Clemens [verfasserIn] Aaron W. James [verfasserIn] Benjamin Levi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 20
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:20

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-021-25143-z

Katalog-ID:	DOAJ052288595

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spelling	10.1038/s41467-021-25143-z doi (DE-627)DOAJ052288595 (DE-599)DOAJ8294374ecf224a3ea40a708dc54a22e2 DE-627 ger DE-627 rakwb eng Seungyong Lee verfasserin aut NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling. Science Q Charles Hwang verfasserin aut Simone Marini verfasserin aut Robert J. Tower verfasserin aut Qizhi Qin verfasserin aut Stefano Negri verfasserin aut Chase A. Pagani verfasserin aut Yuxiao Sun verfasserin aut David M. Stepien verfasserin aut Michael Sorkin verfasserin aut Carrie A. Kubiak verfasserin aut Noelle D. Visser verfasserin aut Carolyn A. Meyers verfasserin aut Yiyun Wang verfasserin aut Husain A. Rasheed verfasserin aut Jiajia Xu verfasserin aut Sarah Miller verfasserin aut Amanda K. Huber verfasserin aut Liliana Minichiello verfasserin aut Paul S. Cederna verfasserin aut Stephen W. P. Kemp verfasserin aut Thomas L. Clemens verfasserin aut Aaron W. James verfasserin aut Benjamin Levi verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 20 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:20 https://doi.org/10.1038/s41467-021-25143-z kostenfrei https://doaj.org/article/8294374ecf224a3ea40a708dc54a22e2 kostenfrei https://doi.org/10.1038/s41467-021-25143-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 20
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allfieldsSound	10.1038/s41467-021-25143-z doi (DE-627)DOAJ052288595 (DE-599)DOAJ8294374ecf224a3ea40a708dc54a22e2 DE-627 ger DE-627 rakwb eng Seungyong Lee verfasserin aut NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling. Science Q Charles Hwang verfasserin aut Simone Marini verfasserin aut Robert J. Tower verfasserin aut Qizhi Qin verfasserin aut Stefano Negri verfasserin aut Chase A. Pagani verfasserin aut Yuxiao Sun verfasserin aut David M. Stepien verfasserin aut Michael Sorkin verfasserin aut Carrie A. Kubiak verfasserin aut Noelle D. Visser verfasserin aut Carolyn A. Meyers verfasserin aut Yiyun Wang verfasserin aut Husain A. Rasheed verfasserin aut Jiajia Xu verfasserin aut Sarah Miller verfasserin aut Amanda K. Huber verfasserin aut Liliana Minichiello verfasserin aut Paul S. Cederna verfasserin aut Stephen W. P. Kemp verfasserin aut Thomas L. Clemens verfasserin aut Aaron W. James verfasserin aut Benjamin Levi verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 20 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:20 https://doi.org/10.1038/s41467-021-25143-z kostenfrei https://doaj.org/article/8294374ecf224a3ea40a708dc54a22e2 kostenfrei https://doi.org/10.1038/s41467-021-25143-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 20
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authorswithroles_txt_mv	Seungyong Lee @@aut@@ Charles Hwang @@aut@@ Simone Marini @@aut@@ Robert J. Tower @@aut@@ Qizhi Qin @@aut@@ Stefano Negri @@aut@@ Chase A. Pagani @@aut@@ Yuxiao Sun @@aut@@ David M. Stepien @@aut@@ Michael Sorkin @@aut@@ Carrie A. Kubiak @@aut@@ Noelle D. Visser @@aut@@ Carolyn A. Meyers @@aut@@ Yiyun Wang @@aut@@ Husain A. Rasheed @@aut@@ Jiajia Xu @@aut@@ Sarah Miller @@aut@@ Amanda K. Huber @@aut@@ Liliana Minichiello @@aut@@ Paul S. Cederna @@aut@@ Stephen W. P. Kemp @@aut@@ Thomas L. Clemens @@aut@@ Aaron W. James @@aut@@ Benjamin Levi @@aut@@
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author	Seungyong Lee
spellingShingle	Seungyong Lee misc Science misc Q NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
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topic_title	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
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title	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
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title_full	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
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author_browse	Seungyong Lee Charles Hwang Simone Marini Robert J. Tower Qizhi Qin Stefano Negri Chase A. Pagani Yuxiao Sun David M. Stepien Michael Sorkin Carrie A. Kubiak Noelle D. Visser Carolyn A. Meyers Yiyun Wang Husain A. Rasheed Jiajia Xu Sarah Miller Amanda K. Huber Liliana Minichiello Paul S. Cederna Stephen W. P. Kemp Thomas L. Clemens Aaron W. James Benjamin Levi
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title_sort	ngf-trka signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
title_auth	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
abstract	Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.
abstractGer	Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.
abstract_unstemmed	Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.
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title_short	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
url	https://doi.org/10.1038/s41467-021-25143-z https://doaj.org/article/8294374ecf224a3ea40a708dc54a22e2 https://doaj.org/toc/2041-1723
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up_date	2024-07-04T00:29:04.568Z
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