Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.

Gespeichert in:

Autor*in:	Constantin Cretu [verfasserIn] Patricia Gee [verfasserIn] Xiang Liu [verfasserIn] Anant Agrawal [verfasserIn] Tuong-Vi Nguyen [verfasserIn] Arun K. Ghosh [verfasserIn] Andrew Cook [verfasserIn] Melissa Jurica [verfasserIn] Nicholas A. Larsen [verfasserIn] Vladimir Pena [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 15
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-021-24741-1

Katalog-ID:	DOAJ052292495

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author	Constantin Cretu
spellingShingle	Constantin Cretu misc Science misc Q Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
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topic_title	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
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title	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
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title_full	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
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author_browse	Constantin Cretu Patricia Gee Xiang Liu Anant Agrawal Tuong-Vi Nguyen Arun K. Ghosh Andrew Cook Melissa Jurica Nicholas A. Larsen Vladimir Pena
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title_sort	structural basis of intron selection by u2 snrnp in the presence of covalent inhibitors
title_auth	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
abstract	Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.
abstractGer	Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.
abstract_unstemmed	Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.
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title_short	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
url	https://doi.org/10.1038/s41467-021-24741-1 https://doaj.org/article/9f060ae1a19640e593633f074975b41b https://doaj.org/toc/2041-1723
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