Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK

Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with...
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Autor*in:	Agha B [verfasserIn] Shajari M [verfasserIn] Slavik-Lencova A [verfasserIn] Kohnen T [verfasserIn] Schmack I [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	DMEK repeat DMEK corneal edema corneal transplantation

Übergeordnetes Werk:	In: Clinical Ophthalmology - Dove Medical Press, 2009, (2019), Seite 477-482
Übergeordnetes Werk:	year:2019 ; pages:477-482

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ052337049

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520			\|a Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation
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allfields	(DE-627)DOAJ052337049 (DE-599)DOAJ9f8b4e57eacc4cb2bed18ffbeb2d251f DE-627 ger DE-627 rakwb eng RE1-994 Agha B verfasserin aut Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology Shajari M verfasserin aut Slavik-Lencova A verfasserin aut Kohnen T verfasserin aut Schmack I verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2019), Seite 477-482 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2019 pages:477-482 https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f kostenfrei https://www.dovepress.com/functional-outcome-of-repeat-descemet-membrane-endothelial-keratoplast-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 477-482
spelling	(DE-627)DOAJ052337049 (DE-599)DOAJ9f8b4e57eacc4cb2bed18ffbeb2d251f DE-627 ger DE-627 rakwb eng RE1-994 Agha B verfasserin aut Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology Shajari M verfasserin aut Slavik-Lencova A verfasserin aut Kohnen T verfasserin aut Schmack I verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2019), Seite 477-482 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2019 pages:477-482 https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f kostenfrei https://www.dovepress.com/functional-outcome-of-repeat-descemet-membrane-endothelial-keratoplast-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 477-482
allfields_unstemmed	(DE-627)DOAJ052337049 (DE-599)DOAJ9f8b4e57eacc4cb2bed18ffbeb2d251f DE-627 ger DE-627 rakwb eng RE1-994 Agha B verfasserin aut Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology Shajari M verfasserin aut Slavik-Lencova A verfasserin aut Kohnen T verfasserin aut Schmack I verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2019), Seite 477-482 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2019 pages:477-482 https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f kostenfrei https://www.dovepress.com/functional-outcome-of-repeat-descemet-membrane-endothelial-keratoplast-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 477-482
allfieldsGer	(DE-627)DOAJ052337049 (DE-599)DOAJ9f8b4e57eacc4cb2bed18ffbeb2d251f DE-627 ger DE-627 rakwb eng RE1-994 Agha B verfasserin aut Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology Shajari M verfasserin aut Slavik-Lencova A verfasserin aut Kohnen T verfasserin aut Schmack I verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2019), Seite 477-482 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2019 pages:477-482 https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f kostenfrei https://www.dovepress.com/functional-outcome-of-repeat-descemet-membrane-endothelial-keratoplast-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 477-482
allfieldsSound	(DE-627)DOAJ052337049 (DE-599)DOAJ9f8b4e57eacc4cb2bed18ffbeb2d251f DE-627 ger DE-627 rakwb eng RE1-994 Agha B verfasserin aut Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology Shajari M verfasserin aut Slavik-Lencova A verfasserin aut Kohnen T verfasserin aut Schmack I verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2019), Seite 477-482 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2019 pages:477-482 https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f kostenfrei https://www.dovepress.com/functional-outcome-of-repeat-descemet-membrane-endothelial-keratoplast-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 477-482
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Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P&lt;0.01 and primary DMEK group, 0.40+-0.36, P&lt;0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P&gt;0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. 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callnumber-first	R - Medicine
author	Agha B
spellingShingle	Agha B misc RE1-994 misc DMEK misc repeat DMEK misc corneal edema misc corneal transplantation misc Ophthalmology Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
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topic_title	RE1-994 Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK DMEK repeat DMEK corneal edema corneal transplantation
topic	misc RE1-994 misc DMEK misc repeat DMEK misc corneal edema misc corneal transplantation misc Ophthalmology
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title	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
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title_full	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
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journal	Clinical Ophthalmology
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author_browse	Agha B Shajari M Slavik-Lencova A Kohnen T Schmack I
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title_sort	functional outcome of repeat descemet membrane endothelial keratoplasty (dmek) for corneal decompensation following graft failure after primary dmek
callnumber	RE1-994
title_auth	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
abstract	Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation
abstractGer	Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation
abstract_unstemmed	Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P<0.01 and primary DMEK group, 0.40+-0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation
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title_short	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
url	https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f https://www.dovepress.com/functional-outcome-of-repeat-descemet-membrane-endothelial-keratoplast-peer-reviewed-article-OPTH https://doaj.org/toc/1177-5483
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author2	Shajari M Slavik-Lencova A Kohnen T Schmack I
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up_date	2024-07-04T00:40:39.531Z
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Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (+-SD) between primary and secondary DMEK was 12.5+-6 months. Preoperative CDVA (logMAR) was 1.97+-0.90 in the repeat DMEK group and 1.38+-0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49+-0.35, P&lt;0.01 and primary DMEK group, 0.40+-0.36, P&lt;0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P&gt;0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. 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Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK

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