The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices

Gamma frequency oscillations (γ, 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation...
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Autor*in:	Yanan Li [verfasserIn] Xin’e Xie [verfasserIn] Hang Xing [verfasserIn] Xiang Yuan [verfasserIn] Yuan Wang [verfasserIn] Yikai Jin [verfasserIn] Jiangang Wang [verfasserIn] Martin Vreugdenhil [verfasserIn] Ying Zhao [verfasserIn] Ruiling Zhang [verfasserIn] Chengbiao Lu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	methamphetamine γ oscillation hippocampus Akt/PKB DR NMDAR

Übergeordnetes Werk:	In: Frontiers in Cellular Neuroscience - Frontiers Media S.A., 2008, 13(2019)
Übergeordnetes Werk:	volume:13 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fncel.2019.00277

Katalog-ID:	DOAJ052382281

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language	English
source	In Frontiers in Cellular Neuroscience 13(2019) volume:13 year:2019
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topic_facet	methamphetamine γ oscillation hippocampus Akt/PKB DR NMDAR Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Cellular Neuroscience
authorswithroles_txt_mv	Yanan Li @@aut@@ Xin’e Xie @@aut@@ Hang Xing @@aut@@ Xiang Yuan @@aut@@ Yuan Wang @@aut@@ Yikai Jin @@aut@@ Jiangang Wang @@aut@@ Martin Vreugdenhil @@aut@@ Ying Zhao @@aut@@ Ruiling Zhang @@aut@@ Chengbiao Lu @@aut@@
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callnumber-first	R - Medicine
author	Yanan Li
spellingShingle	Yanan Li misc RC321-571 misc methamphetamine misc γ oscillation misc hippocampus misc Akt/PKB misc DR misc NMDAR misc Neurosciences. Biological psychiatry. Neuropsychiatry The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices
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topic_title	RC321-571 The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices methamphetamine γ oscillation hippocampus Akt/PKB DR NMDAR
topic	misc RC321-571 misc methamphetamine misc γ oscillation misc hippocampus misc Akt/PKB misc DR misc NMDAR misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc methamphetamine misc γ oscillation misc hippocampus misc Akt/PKB misc DR misc NMDAR misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices
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title_full	The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices
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title_sort	modulation of gamma oscillations by methamphetamine in rat hippocampal slices
callnumber	RC321-571
title_auth	The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices
abstract	Gamma frequency oscillations (γ, 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on γ oscillations. We explored the effects of multiple intracellular kinases on MA modulation of γ induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on γ oscillations, whereas none of them affected baseline γ strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of γ oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.
abstractGer	Gamma frequency oscillations (γ, 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on γ oscillations. We explored the effects of multiple intracellular kinases on MA modulation of γ induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on γ oscillations, whereas none of them affected baseline γ strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of γ oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.
abstract_unstemmed	Gamma frequency oscillations (γ, 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on γ oscillations. We explored the effects of multiple intracellular kinases on MA modulation of γ induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on γ oscillations, whereas none of them affected baseline γ strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of γ oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.
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title_short	The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices
url	https://doi.org/10.3389/fncel.2019.00277 https://doaj.org/article/9f27c7276c6e4a719ba44898ca1b75eb https://www.frontiersin.org/article/10.3389/fncel.2019.00277/full https://doaj.org/toc/1662-5102
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author2	Yanan Li Xin’e Xie Hang Xing Xiang Yuan Yuan Wang Yikai Jin Jiangang Wang Martin Vreugdenhil Ying Zhao Ruiling Zhang Chengbiao Lu
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up_date	2024-07-04T00:51:04.203Z
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The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices

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