Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).

The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive pr...
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Autor*in:	Kathrine Agergård Kaspersen [verfasserIn] Khoa Manh Dinh [verfasserIn] Lise Tornvig Erikstrup [verfasserIn] Kristoffer Sølvsten Burgdorf [verfasserIn] Ole Birger Pedersen [verfasserIn] Erik Sørensen [verfasserIn] Mikkel Steen Petersen [verfasserIn] Henrik Hjalgrim [verfasserIn] Klaus Rostgaard [verfasserIn] Kaspar Rene Nielsen [verfasserIn] Henrik Ullum [verfasserIn] Christian Erikstrup [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 11(2016), 10, p e0164220
Übergeordnetes Werk:	volume:11 ; year:2016 ; number:10, p e0164220

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0164220

Katalog-ID:	DOAJ052440818

Internformat


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520			\|a The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.
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912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4335
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Indexfelder

author_variant	k a k kak k m d kmd l t e lte k s b ksb o b p obp e s es m s p msp h h hh k r kr k r n krn h u hu c e ce
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allfields	10.1371/journal.pone.0164220 doi (DE-627)DOAJ052440818 (DE-599)DOAJ31bf2e52c6b4427eb93c4f0987cfce15 DE-627 ger DE-627 rakwb eng Kathrine Agergård Kaspersen verfasserin aut Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS). 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors. Medicine R Science Q Khoa Manh Dinh verfasserin aut Lise Tornvig Erikstrup verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut Ole Birger Pedersen verfasserin aut Erik Sørensen verfasserin aut Mikkel Steen Petersen verfasserin aut Henrik Hjalgrim verfasserin aut Klaus Rostgaard verfasserin aut Kaspar Rene Nielsen verfasserin aut Henrik Ullum verfasserin aut Christian Erikstrup verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 11(2016), 10, p e0164220 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:11 year:2016 number:10, p e0164220 https://doi.org/10.1371/journal.pone.0164220 kostenfrei https://doaj.org/article/31bf2e52c6b4427eb93c4f0987cfce15 kostenfrei http://europepmc.org/articles/PMC5049789?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 10, p e0164220
spelling	10.1371/journal.pone.0164220 doi (DE-627)DOAJ052440818 (DE-599)DOAJ31bf2e52c6b4427eb93c4f0987cfce15 DE-627 ger DE-627 rakwb eng Kathrine Agergård Kaspersen verfasserin aut Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS). 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors. Medicine R Science Q Khoa Manh Dinh verfasserin aut Lise Tornvig Erikstrup verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut Ole Birger Pedersen verfasserin aut Erik Sørensen verfasserin aut Mikkel Steen Petersen verfasserin aut Henrik Hjalgrim verfasserin aut Klaus Rostgaard verfasserin aut Kaspar Rene Nielsen verfasserin aut Henrik Ullum verfasserin aut Christian Erikstrup verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 11(2016), 10, p e0164220 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:11 year:2016 number:10, p e0164220 https://doi.org/10.1371/journal.pone.0164220 kostenfrei https://doaj.org/article/31bf2e52c6b4427eb93c4f0987cfce15 kostenfrei http://europepmc.org/articles/PMC5049789?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 10, p e0164220
allfields_unstemmed	10.1371/journal.pone.0164220 doi (DE-627)DOAJ052440818 (DE-599)DOAJ31bf2e52c6b4427eb93c4f0987cfce15 DE-627 ger DE-627 rakwb eng Kathrine Agergård Kaspersen verfasserin aut Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS). 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors. Medicine R Science Q Khoa Manh Dinh verfasserin aut Lise Tornvig Erikstrup verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut Ole Birger Pedersen verfasserin aut Erik Sørensen verfasserin aut Mikkel Steen Petersen verfasserin aut Henrik Hjalgrim verfasserin aut Klaus Rostgaard verfasserin aut Kaspar Rene Nielsen verfasserin aut Henrik Ullum verfasserin aut Christian Erikstrup verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 11(2016), 10, p e0164220 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:11 year:2016 number:10, p e0164220 https://doi.org/10.1371/journal.pone.0164220 kostenfrei https://doaj.org/article/31bf2e52c6b4427eb93c4f0987cfce15 kostenfrei http://europepmc.org/articles/PMC5049789?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 10, p e0164220
allfieldsGer	10.1371/journal.pone.0164220 doi (DE-627)DOAJ052440818 (DE-599)DOAJ31bf2e52c6b4427eb93c4f0987cfce15 DE-627 ger DE-627 rakwb eng Kathrine Agergård Kaspersen verfasserin aut Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS). 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors. Medicine R Science Q Khoa Manh Dinh verfasserin aut Lise Tornvig Erikstrup verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut Ole Birger Pedersen verfasserin aut Erik Sørensen verfasserin aut Mikkel Steen Petersen verfasserin aut Henrik Hjalgrim verfasserin aut Klaus Rostgaard verfasserin aut Kaspar Rene Nielsen verfasserin aut Henrik Ullum verfasserin aut Christian Erikstrup verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 11(2016), 10, p e0164220 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:11 year:2016 number:10, p e0164220 https://doi.org/10.1371/journal.pone.0164220 kostenfrei https://doaj.org/article/31bf2e52c6b4427eb93c4f0987cfce15 kostenfrei http://europepmc.org/articles/PMC5049789?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 10, p e0164220
allfieldsSound	10.1371/journal.pone.0164220 doi (DE-627)DOAJ052440818 (DE-599)DOAJ31bf2e52c6b4427eb93c4f0987cfce15 DE-627 ger DE-627 rakwb eng Kathrine Agergård Kaspersen verfasserin aut Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS). 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors. Medicine R Science Q Khoa Manh Dinh verfasserin aut Lise Tornvig Erikstrup verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut Ole Birger Pedersen verfasserin aut Erik Sørensen verfasserin aut Mikkel Steen Petersen verfasserin aut Henrik Hjalgrim verfasserin aut Klaus Rostgaard verfasserin aut Kaspar Rene Nielsen verfasserin aut Henrik Ullum verfasserin aut Christian Erikstrup verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 11(2016), 10, p e0164220 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:11 year:2016 number:10, p e0164220 https://doi.org/10.1371/journal.pone.0164220 kostenfrei https://doaj.org/article/31bf2e52c6b4427eb93c4f0987cfce15 kostenfrei http://europepmc.org/articles/PMC5049789?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 10, p e0164220
language	English
source	In PLoS ONE 11(2016), 10, p e0164220 volume:11 year:2016 number:10, p e0164220
sourceStr	In PLoS ONE 11(2016), 10, p e0164220 volume:11 year:2016 number:10, p e0164220
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Kathrine Agergård Kaspersen @@aut@@ Khoa Manh Dinh @@aut@@ Lise Tornvig Erikstrup @@aut@@ Kristoffer Sølvsten Burgdorf @@aut@@ Ole Birger Pedersen @@aut@@ Erik Sørensen @@aut@@ Mikkel Steen Petersen @@aut@@ Henrik Hjalgrim @@aut@@ Klaus Rostgaard @@aut@@ Kaspar Rene Nielsen @@aut@@ Henrik Ullum @@aut@@ Christian Erikstrup @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ052440818
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author	Kathrine Agergård Kaspersen
spellingShingle	Kathrine Agergård Kaspersen misc Medicine misc R misc Science misc Q Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).
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topic_title	Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS)
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title	Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).
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title_full	Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS)
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author_browse	Kathrine Agergård Kaspersen Khoa Manh Dinh Lise Tornvig Erikstrup Kristoffer Sølvsten Burgdorf Ole Birger Pedersen Erik Sørensen Mikkel Steen Petersen Henrik Hjalgrim Klaus Rostgaard Kaspar Rene Nielsen Henrik Ullum Christian Erikstrup
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title_sort	low-grade inflammation is associated with susceptibility to infection in healthy men: results from the danish blood donor study (dbds)
title_auth	Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).
abstract	The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.
abstractGer	The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.
abstract_unstemmed	The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.
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title_short	Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).
url	https://doi.org/10.1371/journal.pone.0164220 https://doaj.org/article/31bf2e52c6b4427eb93c4f0987cfce15 http://europepmc.org/articles/PMC5049789?pdf=render https://doaj.org/toc/1932-6203
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Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).

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