Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians
Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we...
Ausführliche Beschreibung
Autor*in: |
Owczarek Catherine M. [verfasserIn] Owczarek Aleksander L. [verfasserIn] Board Philip G. [verfasserIn] |
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Englisch |
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2002 |
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Übergeordnetes Werk: |
In: Genetics and Molecular Biology - Sociedade Brasileira de Genética, 2004, 25(2002), 1, Seite 13-19 |
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Übergeordnetes Werk: |
volume:25 ; year:2002 ; number:1 ; pages:13-19 |
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Katalog-ID: |
DOAJ052459144 |
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(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19 |
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(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19 |
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(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19 |
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(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19 |
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QH426-470 Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians Human alpha1-acid glycoprotein RFLP linkage disequilibrium |
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Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians |
abstract |
Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. |
abstractGer |
Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. |
abstract_unstemmed |
Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. |
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Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians |
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|
score |
7.3995256 |