Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians

Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we...
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Gespeichert in:

Autor*in:	Owczarek Catherine M. [verfasserIn] Owczarek Aleksander L. [verfasserIn] Board Philip G. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	Human alpha1-acid glycoprotein RFLP linkage disequilibrium

Übergeordnetes Werk:	In: Genetics and Molecular Biology - Sociedade Brasileira de Genética, 2004, 25(2002), 1, Seite 13-19
Übergeordnetes Werk:	volume:25 ; year:2002 ; number:1 ; pages:13-19

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ052459144

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520			\|a Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies.
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allfields	(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19
spelling	(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19
allfields_unstemmed	(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19
allfieldsGer	(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19
allfieldsSound	(DE-627)DOAJ052459144 (DE-599)DOAJ230a14e580e240288dd4068495eaeb1b DE-627 ger DE-627 rakwb eng QH426-470 Owczarek Catherine M. verfasserin aut Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies. Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics Owczarek Aleksander L. verfasserin aut Board Philip G. verfasserin aut In Genetics and Molecular Biology Sociedade Brasileira de Genética, 2004 25(2002), 1, Seite 13-19 (DE-627)373756763 (DE-600)2126947-6 16784685 nnns volume:25 year:2002 number:1 pages:13-19 https://doaj.org/article/230a14e580e240288dd4068495eaeb1b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004 kostenfrei https://doaj.org/toc/1415-4757 Journal toc kostenfrei https://doaj.org/toc/1678-4685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2002 1 13-19
language	English
source	In Genetics and Molecular Biology 25(2002), 1, Seite 13-19 volume:25 year:2002 number:1 pages:13-19
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topic_facet	Human alpha1-acid glycoprotein RFLP linkage disequilibrium Genetics
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authorswithroles_txt_mv	Owczarek Catherine M. @@aut@@ Owczarek Aleksander L. @@aut@@ Board Philip G. @@aut@@
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callnumber-first	Q - Science
author	Owczarek Catherine M.
spellingShingle	Owczarek Catherine M. misc QH426-470 misc Human alpha1-acid glycoprotein misc RFLP misc linkage disequilibrium misc Genetics Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians
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topic_title	QH426-470 Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians Human alpha1-acid glycoprotein RFLP linkage disequilibrium
topic	misc QH426-470 misc Human alpha1-acid glycoprotein misc RFLP misc linkage disequilibrium misc Genetics
topic_unstemmed	misc QH426-470 misc Human alpha1-acid glycoprotein misc RFLP misc linkage disequilibrium misc Genetics
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title	Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians
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title_full	Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians
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title_sort	identification and characterization of polymorphisms at the hsa a1-acid glycoprotein (orm*) gene locus in caucasians
callnumber	QH426-470
title_auth	Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians
abstract	Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies.
abstractGer	Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies.
abstract_unstemmed	Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies.
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title_short	Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians
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Identification and characterization of polymorphisms at the HSA a1-acid glycoprotein (ORM*) gene locus in Caucasians

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