Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients

The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patie...
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Autor*in:	Lili Li [verfasserIn] Jie Li [verfasserIn] Meiling Gao [verfasserIn] Huimin Fan [verfasserIn] Yanan Wang [verfasserIn] Xin Xu [verfasserIn] Chunfeng Chen [verfasserIn] Junxiao Liu [verfasserIn] Jocelyn Kim [verfasserIn] Roghiyh Aliyari [verfasserIn] Jicai Zhang [verfasserIn] Yujie Jin [verfasserIn] Xiaorong Li [verfasserIn] Feng Ma [verfasserIn] Minxin Shi [verfasserIn] Genhong Cheng [verfasserIn] Heng Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	cytokine serum profile biomarker coronavirus disease-2019 prognosis respiratory syndrome coronavirus 2 cytokine storm interleukin-6

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 11(2021)
Übergeordnetes Werk:	volume:11 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2020.602395

Katalog-ID:	DOAJ052479455

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allfields	10.3389/fimmu.2020.602395 doi (DE-627)DOAJ052479455 (DE-599)DOAJ403c662c564b47b081b802cf113c171e DE-627 ger DE-627 rakwb eng RC581-607 Lili Li verfasserin aut Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis. cytokine serum profile biomarker coronavirus disease-2019 prognosis respiratory syndrome coronavirus 2 cytokine storm interleukin-6 Immunologic diseases. Allergy Lili Li verfasserin aut Jie Li verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Huimin Fan verfasserin aut Huimin Fan verfasserin aut Yanan Wang verfasserin aut Xin Xu verfasserin aut Xin Xu verfasserin aut Chunfeng Chen verfasserin aut Junxiao Liu verfasserin aut Junxiao Liu verfasserin aut Jocelyn Kim verfasserin aut Roghiyh Aliyari verfasserin aut Jicai Zhang verfasserin aut Yujie Jin verfasserin aut Xiaorong Li verfasserin aut Xiaorong Li verfasserin aut Feng Ma verfasserin aut Feng Ma verfasserin aut Minxin Shi verfasserin aut Genhong Cheng verfasserin aut Heng Yang verfasserin aut Heng Yang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.602395 kostenfrei https://doaj.org/article/403c662c564b47b081b802cf113c171e kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.602395/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
spelling	10.3389/fimmu.2020.602395 doi (DE-627)DOAJ052479455 (DE-599)DOAJ403c662c564b47b081b802cf113c171e DE-627 ger DE-627 rakwb eng RC581-607 Lili Li verfasserin aut Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis. cytokine serum profile biomarker coronavirus disease-2019 prognosis respiratory syndrome coronavirus 2 cytokine storm interleukin-6 Immunologic diseases. Allergy Lili Li verfasserin aut Jie Li verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Huimin Fan verfasserin aut Huimin Fan verfasserin aut Yanan Wang verfasserin aut Xin Xu verfasserin aut Xin Xu verfasserin aut Chunfeng Chen verfasserin aut Junxiao Liu verfasserin aut Junxiao Liu verfasserin aut Jocelyn Kim verfasserin aut Roghiyh Aliyari verfasserin aut Jicai Zhang verfasserin aut Yujie Jin verfasserin aut Xiaorong Li verfasserin aut Xiaorong Li verfasserin aut Feng Ma verfasserin aut Feng Ma verfasserin aut Minxin Shi verfasserin aut Genhong Cheng verfasserin aut Heng Yang verfasserin aut Heng Yang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.602395 kostenfrei https://doaj.org/article/403c662c564b47b081b802cf113c171e kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.602395/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
allfields_unstemmed	10.3389/fimmu.2020.602395 doi (DE-627)DOAJ052479455 (DE-599)DOAJ403c662c564b47b081b802cf113c171e DE-627 ger DE-627 rakwb eng RC581-607 Lili Li verfasserin aut Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis. cytokine serum profile biomarker coronavirus disease-2019 prognosis respiratory syndrome coronavirus 2 cytokine storm interleukin-6 Immunologic diseases. Allergy Lili Li verfasserin aut Jie Li verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Huimin Fan verfasserin aut Huimin Fan verfasserin aut Yanan Wang verfasserin aut Xin Xu verfasserin aut Xin Xu verfasserin aut Chunfeng Chen verfasserin aut Junxiao Liu verfasserin aut Junxiao Liu verfasserin aut Jocelyn Kim verfasserin aut Roghiyh Aliyari verfasserin aut Jicai Zhang verfasserin aut Yujie Jin verfasserin aut Xiaorong Li verfasserin aut Xiaorong Li verfasserin aut Feng Ma verfasserin aut Feng Ma verfasserin aut Minxin Shi verfasserin aut Genhong Cheng verfasserin aut Heng Yang verfasserin aut Heng Yang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.602395 kostenfrei https://doaj.org/article/403c662c564b47b081b802cf113c171e kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.602395/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
allfieldsGer	10.3389/fimmu.2020.602395 doi (DE-627)DOAJ052479455 (DE-599)DOAJ403c662c564b47b081b802cf113c171e DE-627 ger DE-627 rakwb eng RC581-607 Lili Li verfasserin aut Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis. cytokine serum profile biomarker coronavirus disease-2019 prognosis respiratory syndrome coronavirus 2 cytokine storm interleukin-6 Immunologic diseases. Allergy Lili Li verfasserin aut Jie Li verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Huimin Fan verfasserin aut Huimin Fan verfasserin aut Yanan Wang verfasserin aut Xin Xu verfasserin aut Xin Xu verfasserin aut Chunfeng Chen verfasserin aut Junxiao Liu verfasserin aut Junxiao Liu verfasserin aut Jocelyn Kim verfasserin aut Roghiyh Aliyari verfasserin aut Jicai Zhang verfasserin aut Yujie Jin verfasserin aut Xiaorong Li verfasserin aut Xiaorong Li verfasserin aut Feng Ma verfasserin aut Feng Ma verfasserin aut Minxin Shi verfasserin aut Genhong Cheng verfasserin aut Heng Yang verfasserin aut Heng Yang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.602395 kostenfrei https://doaj.org/article/403c662c564b47b081b802cf113c171e kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.602395/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
allfieldsSound	10.3389/fimmu.2020.602395 doi (DE-627)DOAJ052479455 (DE-599)DOAJ403c662c564b47b081b802cf113c171e DE-627 ger DE-627 rakwb eng RC581-607 Lili Li verfasserin aut Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis. cytokine serum profile biomarker coronavirus disease-2019 prognosis respiratory syndrome coronavirus 2 cytokine storm interleukin-6 Immunologic diseases. Allergy Lili Li verfasserin aut Jie Li verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Meiling Gao verfasserin aut Huimin Fan verfasserin aut Huimin Fan verfasserin aut Yanan Wang verfasserin aut Xin Xu verfasserin aut Xin Xu verfasserin aut Chunfeng Chen verfasserin aut Junxiao Liu verfasserin aut Junxiao Liu verfasserin aut Jocelyn Kim verfasserin aut Roghiyh Aliyari verfasserin aut Jicai Zhang verfasserin aut Yujie Jin verfasserin aut Xiaorong Li verfasserin aut Xiaorong Li verfasserin aut Feng Ma verfasserin aut Feng Ma verfasserin aut Minxin Shi verfasserin aut Genhong Cheng verfasserin aut Heng Yang verfasserin aut Heng Yang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.602395 kostenfrei https://doaj.org/article/403c662c564b47b081b802cf113c171e kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.602395/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
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callnumber-first	R - Medicine
author	Lili Li
spellingShingle	Lili Li misc RC581-607 misc cytokine serum profile misc biomarker misc coronavirus disease-2019 prognosis misc respiratory syndrome coronavirus 2 misc cytokine storm misc interleukin-6 misc Immunologic diseases. Allergy Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
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topic_title	RC581-607 Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients cytokine serum profile biomarker coronavirus disease-2019 prognosis respiratory syndrome coronavirus 2 cytokine storm interleukin-6
topic	misc RC581-607 misc cytokine serum profile misc biomarker misc coronavirus disease-2019 prognosis misc respiratory syndrome coronavirus 2 misc cytokine storm misc interleukin-6 misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc cytokine serum profile misc biomarker misc coronavirus disease-2019 prognosis misc respiratory syndrome coronavirus 2 misc cytokine storm misc interleukin-6 misc Immunologic diseases. Allergy
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title	Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
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title_full	Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
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title_sort	interleukin-8 as a biomarker for disease prognosis of coronavirus disease-2019 patients
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title_auth	Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
abstract	The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.
abstractGer	The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.
abstract_unstemmed	The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.
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title_short	Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
url	https://doi.org/10.3389/fimmu.2020.602395 https://doaj.org/article/403c662c564b47b081b802cf113c171e https://www.frontiersin.org/articles/10.3389/fimmu.2020.602395/full https://doaj.org/toc/1664-3224
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author2	Lili Li Jie Li Meiling Gao Huimin Fan Yanan Wang Xin Xu Chunfeng Chen Junxiao Liu Jocelyn Kim Roghiyh Aliyari Jicai Zhang Yujie Jin Xiaorong Li Feng Ma Minxin Shi Genhong Cheng Heng Yang
author2Str	Lili Li Jie Li Meiling Gao Huimin Fan Yanan Wang Xin Xu Chunfeng Chen Junxiao Liu Jocelyn Kim Roghiyh Aliyari Jicai Zhang Yujie Jin Xiaorong Li Feng Ma Minxin Shi Genhong Cheng Heng Yang
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up_date	2024-07-04T01:13:17.225Z
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Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients

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