Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5
Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745.
Autor*in: |
Yang Duan [verfasserIn] Dawei Huo [verfasserIn] Jie Gao [verfasserIn] Heng Wu [verfasserIn] Zheng Ye [verfasserIn] Zhe Liu [verfasserIn] Kai Zhang [verfasserIn] Lin Shan [verfasserIn] Xing Zhou [verfasserIn] Yue Wang [verfasserIn] Dongxue Su [verfasserIn] Xiang Ding [verfasserIn] Lei Shi [verfasserIn] Yan Wang [verfasserIn] Yongfeng Shang [verfasserIn] Chenghao Xuan [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2016 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 7(2016), 1, Seite 14 |
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Übergeordnetes Werk: |
volume:7 ; year:2016 ; number:1 ; pages:14 |
Links: |
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DOI / URN: |
10.1038/ncomms12648 |
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Katalog-ID: |
DOAJ052498484 |
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10.1038/ncomms12648 doi (DE-627)DOAJ052498484 (DE-599)DOAJ6442b2c4a6ff46e485d617184856d10d DE-627 ger DE-627 rakwb eng Yang Duan verfasserin aut Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. Science Q Dawei Huo verfasserin aut Jie Gao verfasserin aut Heng Wu verfasserin aut Zheng Ye verfasserin aut Zhe Liu verfasserin aut Kai Zhang verfasserin aut Lin Shan verfasserin aut Xing Zhou verfasserin aut Yue Wang verfasserin aut Dongxue Su verfasserin aut Xiang Ding verfasserin aut Lei Shi verfasserin aut Yan Wang verfasserin aut Yongfeng Shang verfasserin aut Chenghao Xuan verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:14 https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/article/6442b2c4a6ff46e485d617184856d10d kostenfrei https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 14 |
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10.1038/ncomms12648 doi (DE-627)DOAJ052498484 (DE-599)DOAJ6442b2c4a6ff46e485d617184856d10d DE-627 ger DE-627 rakwb eng Yang Duan verfasserin aut Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. Science Q Dawei Huo verfasserin aut Jie Gao verfasserin aut Heng Wu verfasserin aut Zheng Ye verfasserin aut Zhe Liu verfasserin aut Kai Zhang verfasserin aut Lin Shan verfasserin aut Xing Zhou verfasserin aut Yue Wang verfasserin aut Dongxue Su verfasserin aut Xiang Ding verfasserin aut Lei Shi verfasserin aut Yan Wang verfasserin aut Yongfeng Shang verfasserin aut Chenghao Xuan verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:14 https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/article/6442b2c4a6ff46e485d617184856d10d kostenfrei https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 14 |
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10.1038/ncomms12648 doi (DE-627)DOAJ052498484 (DE-599)DOAJ6442b2c4a6ff46e485d617184856d10d DE-627 ger DE-627 rakwb eng Yang Duan verfasserin aut Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. Science Q Dawei Huo verfasserin aut Jie Gao verfasserin aut Heng Wu verfasserin aut Zheng Ye verfasserin aut Zhe Liu verfasserin aut Kai Zhang verfasserin aut Lin Shan verfasserin aut Xing Zhou verfasserin aut Yue Wang verfasserin aut Dongxue Su verfasserin aut Xiang Ding verfasserin aut Lei Shi verfasserin aut Yan Wang verfasserin aut Yongfeng Shang verfasserin aut Chenghao Xuan verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:14 https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/article/6442b2c4a6ff46e485d617184856d10d kostenfrei https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 14 |
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10.1038/ncomms12648 doi (DE-627)DOAJ052498484 (DE-599)DOAJ6442b2c4a6ff46e485d617184856d10d DE-627 ger DE-627 rakwb eng Yang Duan verfasserin aut Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. Science Q Dawei Huo verfasserin aut Jie Gao verfasserin aut Heng Wu verfasserin aut Zheng Ye verfasserin aut Zhe Liu verfasserin aut Kai Zhang verfasserin aut Lin Shan verfasserin aut Xing Zhou verfasserin aut Yue Wang verfasserin aut Dongxue Su verfasserin aut Xiang Ding verfasserin aut Lei Shi verfasserin aut Yan Wang verfasserin aut Yongfeng Shang verfasserin aut Chenghao Xuan verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:14 https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/article/6442b2c4a6ff46e485d617184856d10d kostenfrei https://doi.org/10.1038/ncomms12648 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 14 |
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ubiquitin ligase rnf20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein eg5 |
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Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 |
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Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. |
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Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. |
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Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. |
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Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 |
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