Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling
Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes.
Autor*in: |
Joseph D. Challenger [verfasserIn] Katia Bruxvoort [verfasserIn] Azra C. Ghani [verfasserIn] Lucy C. Okell [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2017 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 9 |
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Übergeordnetes Werk: |
volume:8 ; year:2017 ; number:1 ; pages:9 |
Links: |
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DOI / URN: |
10.1038/s41467-017-01352-3 |
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Katalog-ID: |
DOAJ052566404 |
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10.1038/s41467-017-01352-3 doi (DE-627)DOAJ052566404 (DE-599)DOAJbe1a2b6957f54156a4adac50845795aa DE-627 ger DE-627 rakwb eng Joseph D. Challenger verfasserin aut Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. Science Q Katia Bruxvoort verfasserin aut Azra C. Ghani verfasserin aut Lucy C. Okell verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:9 https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/article/be1a2b6957f54156a4adac50845795aa kostenfrei https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 9 |
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10.1038/s41467-017-01352-3 doi (DE-627)DOAJ052566404 (DE-599)DOAJbe1a2b6957f54156a4adac50845795aa DE-627 ger DE-627 rakwb eng Joseph D. Challenger verfasserin aut Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. Science Q Katia Bruxvoort verfasserin aut Azra C. Ghani verfasserin aut Lucy C. Okell verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:9 https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/article/be1a2b6957f54156a4adac50845795aa kostenfrei https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 9 |
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10.1038/s41467-017-01352-3 doi (DE-627)DOAJ052566404 (DE-599)DOAJbe1a2b6957f54156a4adac50845795aa DE-627 ger DE-627 rakwb eng Joseph D. Challenger verfasserin aut Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. Science Q Katia Bruxvoort verfasserin aut Azra C. Ghani verfasserin aut Lucy C. Okell verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:9 https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/article/be1a2b6957f54156a4adac50845795aa kostenfrei https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 9 |
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10.1038/s41467-017-01352-3 doi (DE-627)DOAJ052566404 (DE-599)DOAJbe1a2b6957f54156a4adac50845795aa DE-627 ger DE-627 rakwb eng Joseph D. Challenger verfasserin aut Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. Science Q Katia Bruxvoort verfasserin aut Azra C. Ghani verfasserin aut Lucy C. Okell verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:9 https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/article/be1a2b6957f54156a4adac50845795aa kostenfrei https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 9 |
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10.1038/s41467-017-01352-3 doi (DE-627)DOAJ052566404 (DE-599)DOAJbe1a2b6957f54156a4adac50845795aa DE-627 ger DE-627 rakwb eng Joseph D. Challenger verfasserin aut Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. Science Q Katia Bruxvoort verfasserin aut Azra C. Ghani verfasserin aut Lucy C. Okell verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:9 https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/article/be1a2b6957f54156a4adac50845795aa kostenfrei https://doi.org/10.1038/s41467-017-01352-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 9 |
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Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling |
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Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. |
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Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. |
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Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal adherence affects treatment outcomes. |
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