The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy

Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018 Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Li⁃na ZHANG [verfasserIn] Shi⁃jing WU [verfasserIn] Hua⁃ying TAO [verfasserIn] Qian LI [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Chinesisch

Erschienen:	2010

Schlagwörter:	Epilepsies, partial Transcranial magnetic stimulation Electroencephalography

Übergeordnetes Werk:	In: Chinese Journal of Contemporary Neurology and Neurosurgery - Tianjin Huanhu Hospital, 2013, 10(2010), 2, Seite 230-234
Übergeordnetes Werk:	volume:10 ; year:2010 ; number:2 ; pages:230-234

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ052570908

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245	1	4	\|a The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy
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520			\|a Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018
650		4	\|a Epilepsies, partial
650		4	\|a Transcranial magnetic stimulation
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700	0		\|a Hua⁃ying TAO \|e verfasserin \|4 aut
700	0		\|a Qian LI \|e verfasserin \|4 aut
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allfields	(DE-627)DOAJ052570908 (DE-599)DOAJ61c3e3348abe477080a3b1f0a536e440 DE-627 ger DE-627 rakwb eng chi RC346-429 Li⁃na ZHANG verfasserin aut The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018 Epilepsies, partial Transcranial magnetic stimulation Electroencephalography Neurology. Diseases of the nervous system Shi⁃jing WU verfasserin aut Hua⁃ying TAO verfasserin aut Qian LI verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 10(2010), 2, Seite 230-234 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:10 year:2010 number:2 pages:230-234 https://doaj.org/article/61c3e3348abe477080a3b1f0a536e440 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/443 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 2 230-234
spelling	(DE-627)DOAJ052570908 (DE-599)DOAJ61c3e3348abe477080a3b1f0a536e440 DE-627 ger DE-627 rakwb eng chi RC346-429 Li⁃na ZHANG verfasserin aut The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018 Epilepsies, partial Transcranial magnetic stimulation Electroencephalography Neurology. Diseases of the nervous system Shi⁃jing WU verfasserin aut Hua⁃ying TAO verfasserin aut Qian LI verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 10(2010), 2, Seite 230-234 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:10 year:2010 number:2 pages:230-234 https://doaj.org/article/61c3e3348abe477080a3b1f0a536e440 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/443 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 2 230-234
allfields_unstemmed	(DE-627)DOAJ052570908 (DE-599)DOAJ61c3e3348abe477080a3b1f0a536e440 DE-627 ger DE-627 rakwb eng chi RC346-429 Li⁃na ZHANG verfasserin aut The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018 Epilepsies, partial Transcranial magnetic stimulation Electroencephalography Neurology. Diseases of the nervous system Shi⁃jing WU verfasserin aut Hua⁃ying TAO verfasserin aut Qian LI verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 10(2010), 2, Seite 230-234 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:10 year:2010 number:2 pages:230-234 https://doaj.org/article/61c3e3348abe477080a3b1f0a536e440 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/443 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 2 230-234
allfieldsGer	(DE-627)DOAJ052570908 (DE-599)DOAJ61c3e3348abe477080a3b1f0a536e440 DE-627 ger DE-627 rakwb eng chi RC346-429 Li⁃na ZHANG verfasserin aut The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018 Epilepsies, partial Transcranial magnetic stimulation Electroencephalography Neurology. Diseases of the nervous system Shi⁃jing WU verfasserin aut Hua⁃ying TAO verfasserin aut Qian LI verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 10(2010), 2, Seite 230-234 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:10 year:2010 number:2 pages:230-234 https://doaj.org/article/61c3e3348abe477080a3b1f0a536e440 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/443 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 2 230-234
allfieldsSound	(DE-627)DOAJ052570908 (DE-599)DOAJ61c3e3348abe477080a3b1f0a536e440 DE-627 ger DE-627 rakwb eng chi RC346-429 Li⁃na ZHANG verfasserin aut The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018 Epilepsies, partial Transcranial magnetic stimulation Electroencephalography Neurology. Diseases of the nervous system Shi⁃jing WU verfasserin aut Hua⁃ying TAO verfasserin aut Qian LI verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 10(2010), 2, Seite 230-234 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:10 year:2010 number:2 pages:230-234 https://doaj.org/article/61c3e3348abe477080a3b1f0a536e440 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/443 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 2 230-234
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Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. 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author	Li⁃na ZHANG
spellingShingle	Li⁃na ZHANG misc RC346-429 misc Epilepsies, partial misc Transcranial magnetic stimulation misc Electroencephalography misc Neurology. Diseases of the nervous system The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy
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topic_title	RC346-429 The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy Epilepsies, partial Transcranial magnetic stimulation Electroencephalography
topic	misc RC346-429 misc Epilepsies, partial misc Transcranial magnetic stimulation misc Electroencephalography misc Neurology. Diseases of the nervous system
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title	The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy
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title_full	The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy
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title_sort	clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy
callnumber	RC346-429
title_auth	The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy
abstract	Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018
abstractGer	Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018
abstract_unstemmed	Objective To observe the effectiveness of low⁃frequency and subthreshold repetitive transcranial magnetic stimulation (rTMS) on patients with refractory epilepsy. Methods Twelve subjects with refractory and focal epilepsy were involved. rTMS as a treatment with 600 pulses, intensity of 90% motor resting threshold and 0.50 Hz frequency was administrated once per day, 5 days as one course. Five of twelve patients accepted the second course treatment. The number of seizure frequency, seizure days, and seizure latency at pre ⁃ and pro ⁃ treatment were measured and compared. Meanwhile, the data of electroencephalography (EEG) was collected for calculation. Compared epileptic spike discharges in the EEG and relative power of each frequency distribution (%) by using the software running on MATLAB 7.0. Results rTMS significantly decreased the frequency and days of seizures after 5 days of the first treatment in all 12 patients (t = 2.450, P = 0.032; t = 2.797, P = 0.017), and prolonged seizure latency in 8 patients. Furthermore, high⁃frequency β band relative power distribution showed significant increase (t = ⁃ 2.703, P = 0.021), especially in α band (t = ⁃ 3.680, P = 0.004); while low⁃frequency δ band decreased (t = 3.047, P = 0.011). The amount of EEG sharp waves was reduced significantly (t = 2.411, P = 0.035). Compared with the first course, these indexes were improved in the second treatment. The changes of δ and α bands were great, especially δ band decreased by 2.08 times which suggested that EEG background waves were improved evidently. Conclusion Low ⁃ frequency and subthreshold rTMS can decrease the events of epileptic seizures, prolong seizure latency, and improve epileptic EEG discharges. As a new method in the area of non ⁃ drug ⁃ induced neuro ⁃ modulation, low ⁃ frequency rTMS is a safe and effective treatment for refractory epilepsy. It shows good prospects for clinical application of low ⁃frequency rTMS in refractory epilepsy. DOI：10.3969/j.issn.1672-6731.2010.02.018
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title_short	The clinical exploration of low ⁃frequency repetitive transcranial magnetic stimulation in refractory epilepsy
url	https://doaj.org/article/61c3e3348abe477080a3b1f0a536e440 http://www.cjcnn.org/index.php/cjcnn/article/view/443 https://doaj.org/toc/1672-6731
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author2	Shi⁃jing WU Hua⁃ying TAO Qian LI
author2Str	Shi⁃jing WU Hua⁃ying TAO Qian LI
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up_date	2024-07-04T01:34:02.177Z
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