Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience

The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yuan Liu [verfasserIn] Siyi Guo [verfasserIn] Jinsong Wu [verfasserIn] Rongai Wang [verfasserIn] Jinbo Liu [verfasserIn] Yan Liu [verfasserIn] Bin Lv [verfasserIn] Nan Liu [verfasserIn] Ling Jiang [verfasserIn] Xiaoli Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features

Übergeordnetes Werk:	In: Endocrine Connections - Bioscientifica, 2013, 10(2021), 11, Seite 1428-1434
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:11 ; pages:1428-1434

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ05275765X

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520			\|a The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years.
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allfields	(DE-627)DOAJ05275765X (DE-599)DOAJ4914110f40644cf49997c8beb0c313cc DE-627 ger DE-627 rakwb eng RC648-665 Yuan Liu verfasserin aut Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years. primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features Diseases of the endocrine glands. Clinical endocrinology Siyi Guo verfasserin aut Jinsong Wu verfasserin aut Rongai Wang verfasserin aut Jinbo Liu verfasserin aut Yan Liu verfasserin aut Bin Lv verfasserin aut Nan Liu verfasserin aut Ling Jiang verfasserin aut Xiaoli Zhang verfasserin aut In Endocrine Connections Bioscientifica, 2013 10(2021), 11, Seite 1428-1434 (DE-627)718731077 (DE-600)2668428-7 20493614 nnns volume:10 year:2021 number:11 pages:1428-1434 https://doi.org/10.1530/EC-21-0382 kostenfrei https://doaj.org/article/4914110f40644cf49997c8beb0c313cc kostenfrei https://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0382.xml kostenfrei https://doaj.org/toc/2049-3614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 1428-1434
spelling	(DE-627)DOAJ05275765X (DE-599)DOAJ4914110f40644cf49997c8beb0c313cc DE-627 ger DE-627 rakwb eng RC648-665 Yuan Liu verfasserin aut Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years. primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features Diseases of the endocrine glands. Clinical endocrinology Siyi Guo verfasserin aut Jinsong Wu verfasserin aut Rongai Wang verfasserin aut Jinbo Liu verfasserin aut Yan Liu verfasserin aut Bin Lv verfasserin aut Nan Liu verfasserin aut Ling Jiang verfasserin aut Xiaoli Zhang verfasserin aut In Endocrine Connections Bioscientifica, 2013 10(2021), 11, Seite 1428-1434 (DE-627)718731077 (DE-600)2668428-7 20493614 nnns volume:10 year:2021 number:11 pages:1428-1434 https://doi.org/10.1530/EC-21-0382 kostenfrei https://doaj.org/article/4914110f40644cf49997c8beb0c313cc kostenfrei https://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0382.xml kostenfrei https://doaj.org/toc/2049-3614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 1428-1434
allfields_unstemmed	(DE-627)DOAJ05275765X (DE-599)DOAJ4914110f40644cf49997c8beb0c313cc DE-627 ger DE-627 rakwb eng RC648-665 Yuan Liu verfasserin aut Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years. primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features Diseases of the endocrine glands. Clinical endocrinology Siyi Guo verfasserin aut Jinsong Wu verfasserin aut Rongai Wang verfasserin aut Jinbo Liu verfasserin aut Yan Liu verfasserin aut Bin Lv verfasserin aut Nan Liu verfasserin aut Ling Jiang verfasserin aut Xiaoli Zhang verfasserin aut In Endocrine Connections Bioscientifica, 2013 10(2021), 11, Seite 1428-1434 (DE-627)718731077 (DE-600)2668428-7 20493614 nnns volume:10 year:2021 number:11 pages:1428-1434 https://doi.org/10.1530/EC-21-0382 kostenfrei https://doaj.org/article/4914110f40644cf49997c8beb0c313cc kostenfrei https://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0382.xml kostenfrei https://doaj.org/toc/2049-3614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 1428-1434
allfieldsGer	(DE-627)DOAJ05275765X (DE-599)DOAJ4914110f40644cf49997c8beb0c313cc DE-627 ger DE-627 rakwb eng RC648-665 Yuan Liu verfasserin aut Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years. primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features Diseases of the endocrine glands. Clinical endocrinology Siyi Guo verfasserin aut Jinsong Wu verfasserin aut Rongai Wang verfasserin aut Jinbo Liu verfasserin aut Yan Liu verfasserin aut Bin Lv verfasserin aut Nan Liu verfasserin aut Ling Jiang verfasserin aut Xiaoli Zhang verfasserin aut In Endocrine Connections Bioscientifica, 2013 10(2021), 11, Seite 1428-1434 (DE-627)718731077 (DE-600)2668428-7 20493614 nnns volume:10 year:2021 number:11 pages:1428-1434 https://doi.org/10.1530/EC-21-0382 kostenfrei https://doaj.org/article/4914110f40644cf49997c8beb0c313cc kostenfrei https://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0382.xml kostenfrei https://doaj.org/toc/2049-3614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 1428-1434
allfieldsSound	(DE-627)DOAJ05275765X (DE-599)DOAJ4914110f40644cf49997c8beb0c313cc DE-627 ger DE-627 rakwb eng RC648-665 Yuan Liu verfasserin aut Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years. primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features Diseases of the endocrine glands. Clinical endocrinology Siyi Guo verfasserin aut Jinsong Wu verfasserin aut Rongai Wang verfasserin aut Jinbo Liu verfasserin aut Yan Liu verfasserin aut Bin Lv verfasserin aut Nan Liu verfasserin aut Ling Jiang verfasserin aut Xiaoli Zhang verfasserin aut In Endocrine Connections Bioscientifica, 2013 10(2021), 11, Seite 1428-1434 (DE-627)718731077 (DE-600)2668428-7 20493614 nnns volume:10 year:2021 number:11 pages:1428-1434 https://doi.org/10.1530/EC-21-0382 kostenfrei https://doaj.org/article/4914110f40644cf49997c8beb0c313cc kostenfrei https://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0382.xml kostenfrei https://doaj.org/toc/2049-3614 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11 1428-1434
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callnumber-first	R - Medicine
author	Yuan Liu
spellingShingle	Yuan Liu misc RC648-665 misc primary hyperparathyroidism misc asymptomatic primary hyperparathyroidism misc china misc clinical features misc Diseases of the endocrine glands. Clinical endocrinology Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience
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topic_title	RC648-665 Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features
topic	misc RC648-665 misc primary hyperparathyroidism misc asymptomatic primary hyperparathyroidism misc china misc clinical features misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc primary hyperparathyroidism misc asymptomatic primary hyperparathyroidism misc china misc clinical features misc Diseases of the endocrine glands. Clinical endocrinology
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title	Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience
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title_sort	changes in clinical patterns of chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience
callnumber	RC648-665
title_auth	Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience
abstract	The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years.
abstractGer	The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years.
abstract_unstemmed	The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years.
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title_short	Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience
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Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. 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Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience

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