Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola

Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd to...
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Autor*in:	Xu Hongyan [verfasserIn] Xie Zhanling [verfasserIn] Jiang Hongchen [verfasserIn] Guo Jing [verfasserIn] Meng Qing [verfasserIn] Zhao Yuan [verfasserIn] Wang Xiaofang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	cadmium stress transporter protein enzymatic antioxidant non-enzymatic antioxidant gene regulatory network

Übergeordnetes Werk:	In: Mycobiology - Taylor & Francis Group, 2018, 49(2021), 4, Seite 421-433
Übergeordnetes Werk:	volume:49 ; year:2021 ; number:4 ; pages:421-433

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/12298093.2021.1937882

Katalog-ID:	DOAJ052761967

Internformat


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authorswithroles_txt_mv	Xu Hongyan @@aut@@ Xie Zhanling @@aut@@ Jiang Hongchen @@aut@@ Guo Jing @@aut@@ Meng Qing @@aut@@ Zhao Yuan @@aut@@ Wang Xiaofang @@aut@@
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author	Xu Hongyan
spellingShingle	Xu Hongyan misc QK1-989 misc cadmium stress misc transporter protein misc enzymatic antioxidant misc non-enzymatic antioxidant misc gene regulatory network misc Botany Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola
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topic_title	QK1-989 Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola cadmium stress transporter protein enzymatic antioxidant non-enzymatic antioxidant gene regulatory network
topic	misc QK1-989 misc cadmium stress misc transporter protein misc enzymatic antioxidant misc non-enzymatic antioxidant misc gene regulatory network misc Botany
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title	Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola
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title_full	Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola
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title_sort	transcriptome analysis and expression profiling of molecular responses to cd toxicity in morchella spongiola
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title_auth	Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola
abstract	Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd2+. The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymatic/non-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.
abstractGer	Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd2+. The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymatic/non-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.
abstract_unstemmed	Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd2+. The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymatic/non-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.
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title_short	Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola
url	https://doi.org/10.1080/12298093.2021.1937882 https://doaj.org/article/26257a1c20ad4fc6b862d333aed86638 http://dx.doi.org/10.1080/12298093.2021.1937882 https://doaj.org/toc/1229-8093 https://doaj.org/toc/2092-9323
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up_date	2024-07-03T13:54:49.914Z
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Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity in Morchella spongiola

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