IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the...
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Autor*in:	Niall P. Quinn [verfasserIn] Lucía García-Gutiérrez [verfasserIn] Carolanne Doherty [verfasserIn] Alexander von Kriegsheim [verfasserIn] Emma Fallahi [verfasserIn] David B. Sacks [verfasserIn] David Matallanas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	IQGAP1 MST2 LATS1 YAP1 Hippo bile acid

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 10(2021), 2, p 478
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:2, p 478

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells10020478

Katalog-ID:	DOAJ052793222

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language	English
source	In Cells 10(2021), 2, p 478 volume:10 year:2021 number:2, p 478
sourceStr	In Cells 10(2021), 2, p 478 volume:10 year:2021 number:2, p 478
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institution	findex.gbv.de
topic_facet	IQGAP1 MST2 LATS1 YAP1 Hippo bile acid Cytology
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container_title	Cells
authorswithroles_txt_mv	Niall P. Quinn @@aut@@ Lucía García-Gutiérrez @@aut@@ Carolanne Doherty @@aut@@ Alexander von Kriegsheim @@aut@@ Emma Fallahi @@aut@@ David B. Sacks @@aut@@ David Matallanas @@aut@@
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callnumber-first	Q - Science
author	Niall P. Quinn
spellingShingle	Niall P. Quinn misc QH573-671 misc IQGAP1 misc MST2 misc LATS1 misc YAP1 misc Hippo misc bile acid misc Cytology IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway
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topic_title	QH573-671 IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway IQGAP1 MST2 LATS1 YAP1 Hippo bile acid
topic	misc QH573-671 misc IQGAP1 misc MST2 misc LATS1 misc YAP1 misc Hippo misc bile acid misc Cytology
topic_unstemmed	misc QH573-671 misc IQGAP1 misc MST2 misc LATS1 misc YAP1 misc Hippo misc bile acid misc Cytology
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title	IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway
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title_full	IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway
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title_sort	iqgap1 is a scaffold of the core proteins of the hippo pathway and negatively regulates the pro-apoptotic signal mediated by this pathway
callnumber	QH573-671
title_auth	IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway
abstract	The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the diverse output controlled by this pathway. In this study we have identified the scaffold protein IQGAP1 as a novel interactor of the core kinases of the Hippo pathway, MST2 and LATS1. Our results indicate that IQGAP1 scaffolds MST2 and LATS1 supresses their kinase activity and YAP1-dependent transcription. Additionally, we show that IQGAP1 is a negative regulator of the non-canonical pro-apoptotic pathway and may enable the crosstalk between this pathway and the ERK and AKT signalling modules. Our data also show that bile acids regulate the IQGAP1-MST2-LATS1 signalling module in hepatocellular carcinoma cells, which could be necessary for the inhibition of MST2-dependent apoptosis and hepatocyte transformation.
abstractGer	The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the diverse output controlled by this pathway. In this study we have identified the scaffold protein IQGAP1 as a novel interactor of the core kinases of the Hippo pathway, MST2 and LATS1. Our results indicate that IQGAP1 scaffolds MST2 and LATS1 supresses their kinase activity and YAP1-dependent transcription. Additionally, we show that IQGAP1 is a negative regulator of the non-canonical pro-apoptotic pathway and may enable the crosstalk between this pathway and the ERK and AKT signalling modules. Our data also show that bile acids regulate the IQGAP1-MST2-LATS1 signalling module in hepatocellular carcinoma cells, which could be necessary for the inhibition of MST2-dependent apoptosis and hepatocyte transformation.
abstract_unstemmed	The Hippo pathway regulates a complex signalling network which mediates several biological functions including cell proliferation, organ size and apoptosis. Several scaffold proteins regulate the crosstalk of the members of the pathway with other signalling pathways and play an important role in the diverse output controlled by this pathway. In this study we have identified the scaffold protein IQGAP1 as a novel interactor of the core kinases of the Hippo pathway, MST2 and LATS1. Our results indicate that IQGAP1 scaffolds MST2 and LATS1 supresses their kinase activity and YAP1-dependent transcription. Additionally, we show that IQGAP1 is a negative regulator of the non-canonical pro-apoptotic pathway and may enable the crosstalk between this pathway and the ERK and AKT signalling modules. Our data also show that bile acids regulate the IQGAP1-MST2-LATS1 signalling module in hepatocellular carcinoma cells, which could be necessary for the inhibition of MST2-dependent apoptosis and hepatocyte transformation.
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container_issue	2, p 478
title_short	IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway
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IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

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