Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice
Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final prod...
Ausführliche Beschreibung
Autor*in: |
Hanna Lewandowska [verfasserIn] Andrzej Eljaszewicz [verfasserIn] Izabela Poplawska [verfasserIn] Marlena Tynecka [verfasserIn] Alicja Walewska [verfasserIn] Kamil Grubczak [verfasserIn] Jordan Holl [verfasserIn] Hady Razak Hady [verfasserIn] Slawomir Lech Czaban [verfasserIn] Joanna Reszec [verfasserIn] Grażyna Przybytniak [verfasserIn] Wojciech Głuszewski [verfasserIn] Jarosław Sadło [verfasserIn] Małgorzata Dąbrowska-Gralak [verfasserIn] Cezary Kowalewski [verfasserIn] Piotr Fiedor [verfasserIn] Tomasz Oldak [verfasserIn] Artur Kaminski [verfasserIn] Zbigniew Zimek [verfasserIn] Marcin Moniuszko [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2021 |
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In: International Journal of Molecular Sciences - MDPI AG, 2003, 22(2021), 16, p 8467 |
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volume:22 ; year:2021 ; number:16, p 8467 |
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DOI / URN: |
10.3390/ijms22168467 |
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Katalog-ID: |
DOAJ052814513 |
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520 | |a Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. | ||
650 | 4 | |a human acellular dermal matrices | |
650 | 4 | |a ADM | |
650 | 4 | |a biological dressing | |
650 | 4 | |a skin substitutes | |
650 | 4 | |a radiation sterilization | |
650 | 4 | |a collagen | |
653 | 0 | |a Biology (General) | |
653 | 0 | |a Chemistry | |
700 | 0 | |a Andrzej Eljaszewicz |e verfasserin |4 aut | |
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700 | 0 | |a Alicja Walewska |e verfasserin |4 aut | |
700 | 0 | |a Kamil Grubczak |e verfasserin |4 aut | |
700 | 0 | |a Jordan Holl |e verfasserin |4 aut | |
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700 | 0 | |a Zbigniew Zimek |e verfasserin |4 aut | |
700 | 0 | |a Marcin Moniuszko |e verfasserin |4 aut | |
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10.3390/ijms22168467 doi (DE-627)DOAJ052814513 (DE-599)DOAJ1a2f1d5d04584a6ea4d7456c38e36eb2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Hanna Lewandowska verfasserin aut Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. human acellular dermal matrices ADM biological dressing skin substitutes radiation sterilization collagen Biology (General) Chemistry Andrzej Eljaszewicz verfasserin aut Izabela Poplawska verfasserin aut Marlena Tynecka verfasserin aut Alicja Walewska verfasserin aut Kamil Grubczak verfasserin aut Jordan Holl verfasserin aut Hady Razak Hady verfasserin aut Slawomir Lech Czaban verfasserin aut Joanna Reszec verfasserin aut Grażyna Przybytniak verfasserin aut Wojciech Głuszewski verfasserin aut Jarosław Sadło verfasserin aut Małgorzata Dąbrowska-Gralak verfasserin aut Cezary Kowalewski verfasserin aut Piotr Fiedor verfasserin aut Tomasz Oldak verfasserin aut Artur Kaminski verfasserin aut Zbigniew Zimek verfasserin aut Marcin Moniuszko verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 16, p 8467 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:16, p 8467 https://doi.org/10.3390/ijms22168467 kostenfrei https://doaj.org/article/1a2f1d5d04584a6ea4d7456c38e36eb2 kostenfrei https://www.mdpi.com/1422-0067/22/16/8467 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 16, p 8467 |
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10.3390/ijms22168467 doi (DE-627)DOAJ052814513 (DE-599)DOAJ1a2f1d5d04584a6ea4d7456c38e36eb2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Hanna Lewandowska verfasserin aut Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. human acellular dermal matrices ADM biological dressing skin substitutes radiation sterilization collagen Biology (General) Chemistry Andrzej Eljaszewicz verfasserin aut Izabela Poplawska verfasserin aut Marlena Tynecka verfasserin aut Alicja Walewska verfasserin aut Kamil Grubczak verfasserin aut Jordan Holl verfasserin aut Hady Razak Hady verfasserin aut Slawomir Lech Czaban verfasserin aut Joanna Reszec verfasserin aut Grażyna Przybytniak verfasserin aut Wojciech Głuszewski verfasserin aut Jarosław Sadło verfasserin aut Małgorzata Dąbrowska-Gralak verfasserin aut Cezary Kowalewski verfasserin aut Piotr Fiedor verfasserin aut Tomasz Oldak verfasserin aut Artur Kaminski verfasserin aut Zbigniew Zimek verfasserin aut Marcin Moniuszko verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 16, p 8467 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:16, p 8467 https://doi.org/10.3390/ijms22168467 kostenfrei https://doaj.org/article/1a2f1d5d04584a6ea4d7456c38e36eb2 kostenfrei https://www.mdpi.com/1422-0067/22/16/8467 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 16, p 8467 |
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10.3390/ijms22168467 doi (DE-627)DOAJ052814513 (DE-599)DOAJ1a2f1d5d04584a6ea4d7456c38e36eb2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Hanna Lewandowska verfasserin aut Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. human acellular dermal matrices ADM biological dressing skin substitutes radiation sterilization collagen Biology (General) Chemistry Andrzej Eljaszewicz verfasserin aut Izabela Poplawska verfasserin aut Marlena Tynecka verfasserin aut Alicja Walewska verfasserin aut Kamil Grubczak verfasserin aut Jordan Holl verfasserin aut Hady Razak Hady verfasserin aut Slawomir Lech Czaban verfasserin aut Joanna Reszec verfasserin aut Grażyna Przybytniak verfasserin aut Wojciech Głuszewski verfasserin aut Jarosław Sadło verfasserin aut Małgorzata Dąbrowska-Gralak verfasserin aut Cezary Kowalewski verfasserin aut Piotr Fiedor verfasserin aut Tomasz Oldak verfasserin aut Artur Kaminski verfasserin aut Zbigniew Zimek verfasserin aut Marcin Moniuszko verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 16, p 8467 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:16, p 8467 https://doi.org/10.3390/ijms22168467 kostenfrei https://doaj.org/article/1a2f1d5d04584a6ea4d7456c38e36eb2 kostenfrei https://www.mdpi.com/1422-0067/22/16/8467 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 16, p 8467 |
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10.3390/ijms22168467 doi (DE-627)DOAJ052814513 (DE-599)DOAJ1a2f1d5d04584a6ea4d7456c38e36eb2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Hanna Lewandowska verfasserin aut Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. human acellular dermal matrices ADM biological dressing skin substitutes radiation sterilization collagen Biology (General) Chemistry Andrzej Eljaszewicz verfasserin aut Izabela Poplawska verfasserin aut Marlena Tynecka verfasserin aut Alicja Walewska verfasserin aut Kamil Grubczak verfasserin aut Jordan Holl verfasserin aut Hady Razak Hady verfasserin aut Slawomir Lech Czaban verfasserin aut Joanna Reszec verfasserin aut Grażyna Przybytniak verfasserin aut Wojciech Głuszewski verfasserin aut Jarosław Sadło verfasserin aut Małgorzata Dąbrowska-Gralak verfasserin aut Cezary Kowalewski verfasserin aut Piotr Fiedor verfasserin aut Tomasz Oldak verfasserin aut Artur Kaminski verfasserin aut Zbigniew Zimek verfasserin aut Marcin Moniuszko verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 16, p 8467 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:16, p 8467 https://doi.org/10.3390/ijms22168467 kostenfrei https://doaj.org/article/1a2f1d5d04584a6ea4d7456c38e36eb2 kostenfrei https://www.mdpi.com/1422-0067/22/16/8467 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 16, p 8467 |
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QH301-705.5 QD1-999 Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice human acellular dermal matrices ADM biological dressing skin substitutes radiation sterilization collagen |
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Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice |
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Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice |
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Hanna Lewandowska |
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Hanna Lewandowska Andrzej Eljaszewicz Izabela Poplawska Marlena Tynecka Alicja Walewska Kamil Grubczak Jordan Holl Hady Razak Hady Slawomir Lech Czaban Joanna Reszec Grażyna Przybytniak Wojciech Głuszewski Jarosław Sadło Małgorzata Dąbrowska-Gralak Cezary Kowalewski Piotr Fiedor Tomasz Oldak Artur Kaminski Zbigniew Zimek Marcin Moniuszko |
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optimization of novel human acellular dermal dressing sterilization for routine use in clinical practice |
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Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice |
abstract |
Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. |
abstractGer |
Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. |
abstract_unstemmed |
Gamma rays and electrons with kinetic energy up to 10 MeV are routinely used to sterilize biomaterials. To date, the effects of irradiation upon human acellular dermal matrices (hADMs) remain to be fully elucidated. The optimal irradiation dosage remains a critical parameter affecting the final product structure and, by extension, its therapeutic potential. ADM slides were prepared by various digestion methods. The influence of various doses of radiation sterilization using a high-energy electron beam on the structure of collagen, the formation of free radicals and immune responses to non-irradiated (native) and irradiated hADM was investigated. The study of the structure changes was carried out using the following methods: immunohistology, immunoblotting, and electron paramagnetic resonance (EPR) spectroscopy. It was shown that radiation sterilization did not change the architecture and three-dimensional structure of hADM; however, it significantly influenced the degradation of collagen fibers and induced the production of free radicals in a dose-dependent manner. More importantly, the observed effects did not disrupt the therapeutic potential of the new transplants. Therefore, radiation sterilization at a dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential. |
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Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice |
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