Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches

Currently, the median overall survival of PDAC patients rarely exceeds 1 year and has an overall 5-year survival rate of about 9%. These numbers are anticipated to worsen in the future due to the lack of understanding of the factors involved in its strong chemoresistance. Chemotherapy remains the on...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Tiago M. A. Carvalho [verfasserIn]

Daria Di Molfetta [verfasserIn]

Maria Raffaella Greco [verfasserIn]

Tomas Koltai [verfasserIn]

Khalid O. Alfarouk [verfasserIn]

Stephan J. Reshkin [verfasserIn]

Rosa A. Cardone [verfasserIn]

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2021

Schlagwörter:

pancreatic ductal adenocarcinoma

tumor microenvironment

chemoresistance

treatment

extracellular matrix

desmoplasia

Übergeordnetes Werk:

In: Cancers - MDPI AG, 2010, 13(2021), 23, p 6135

Übergeordnetes Werk:

volume:13 ; year:2021 ; number:23, p 6135

Links:

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Journal toc

DOI / URN:

10.3390/cancers13236135

Katalog-ID:

DOAJ052819795

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