Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility

A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity o...
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Autor*in:	Peng Sun [verfasserIn] Da-Gang Liu [verfasserIn] Xiang-Ming Ye [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron

Übergeordnetes Werk:	In: Frontiers in Neurology - Frontiers Media S.A., 2010, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fneur.2021.656752

Katalog-ID:	DOAJ052841456

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allfields	10.3389/fneur.2021.656752 doi (DE-627)DOAJ052841456 (DE-599)DOAJbba2b741723b4841a0bddcff638dbc4a DE-627 ger DE-627 rakwb eng RC346-429 Peng Sun verfasserin aut Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility. cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron Neurology. Diseases of the nervous system Da-Gang Liu verfasserin aut Xiang-Ming Ye verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 12(2021) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:12 year:2021 https://doi.org/10.3389/fneur.2021.656752 kostenfrei https://doaj.org/article/bba2b741723b4841a0bddcff638dbc4a kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2021.656752/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
spelling	10.3389/fneur.2021.656752 doi (DE-627)DOAJ052841456 (DE-599)DOAJbba2b741723b4841a0bddcff638dbc4a DE-627 ger DE-627 rakwb eng RC346-429 Peng Sun verfasserin aut Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility. cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron Neurology. Diseases of the nervous system Da-Gang Liu verfasserin aut Xiang-Ming Ye verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 12(2021) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:12 year:2021 https://doi.org/10.3389/fneur.2021.656752 kostenfrei https://doaj.org/article/bba2b741723b4841a0bddcff638dbc4a kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2021.656752/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfields_unstemmed	10.3389/fneur.2021.656752 doi (DE-627)DOAJ052841456 (DE-599)DOAJbba2b741723b4841a0bddcff638dbc4a DE-627 ger DE-627 rakwb eng RC346-429 Peng Sun verfasserin aut Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility. cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron Neurology. Diseases of the nervous system Da-Gang Liu verfasserin aut Xiang-Ming Ye verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 12(2021) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:12 year:2021 https://doi.org/10.3389/fneur.2021.656752 kostenfrei https://doaj.org/article/bba2b741723b4841a0bddcff638dbc4a kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2021.656752/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsGer	10.3389/fneur.2021.656752 doi (DE-627)DOAJ052841456 (DE-599)DOAJbba2b741723b4841a0bddcff638dbc4a DE-627 ger DE-627 rakwb eng RC346-429 Peng Sun verfasserin aut Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility. cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron Neurology. Diseases of the nervous system Da-Gang Liu verfasserin aut Xiang-Ming Ye verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 12(2021) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:12 year:2021 https://doi.org/10.3389/fneur.2021.656752 kostenfrei https://doaj.org/article/bba2b741723b4841a0bddcff638dbc4a kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2021.656752/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fneur.2021.656752 doi (DE-627)DOAJ052841456 (DE-599)DOAJbba2b741723b4841a0bddcff638dbc4a DE-627 ger DE-627 rakwb eng RC346-429 Peng Sun verfasserin aut Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility. cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron Neurology. Diseases of the nervous system Da-Gang Liu verfasserin aut Xiang-Ming Ye verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 12(2021) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:12 year:2021 https://doi.org/10.3389/fneur.2021.656752 kostenfrei https://doaj.org/article/bba2b741723b4841a0bddcff638dbc4a kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2021.656752/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Neurology 12(2021) volume:12 year:2021
sourceStr	In Frontiers in Neurology 12(2021) volume:12 year:2021
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topic_facet	cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron Neurology. Diseases of the nervous system
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container_title	Frontiers in Neurology
authorswithroles_txt_mv	Peng Sun @@aut@@ Da-Gang Liu @@aut@@ Xiang-Ming Ye @@aut@@
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callnumber-first	R - Medicine
author	Peng Sun
spellingShingle	Peng Sun misc RC346-429 misc cholinergic receptors misc α7 nicotinic acetylcholine receptors misc epilepsy misc seizure susceptibility misc CA1 pyramidal neuron misc Neurology. Diseases of the nervous system Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility
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topic_title	RC346-429 Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility cholinergic receptors α7 nicotinic acetylcholine receptors epilepsy seizure susceptibility CA1 pyramidal neuron
topic	misc RC346-429 misc cholinergic receptors misc α7 nicotinic acetylcholine receptors misc epilepsy misc seizure susceptibility misc CA1 pyramidal neuron misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc cholinergic receptors misc α7 nicotinic acetylcholine receptors misc epilepsy misc seizure susceptibility misc CA1 pyramidal neuron misc Neurology. Diseases of the nervous system
topic_browse	misc RC346-429 misc cholinergic receptors misc α7 nicotinic acetylcholine receptors misc epilepsy misc seizure susceptibility misc CA1 pyramidal neuron misc Neurology. Diseases of the nervous system
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title	Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility
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title_full	Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility
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title_sort	nicotinic acetylcholine receptor α7 subunit is an essential regulator of seizure susceptibility
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title_auth	Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility
abstract	A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility.
abstractGer	A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility.
abstract_unstemmed	A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility.
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title_short	Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility
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Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility

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