Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect

To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intrace...
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Autor*in:	Man Xu [verfasserIn] Guangmeng Li [verfasserIn] Haoxiang Zhang [verfasserIn] Xiaoming Chen [verfasserIn] Yi Li [verfasserIn] Qianming Yao [verfasserIn] Maobin Xie [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release

Übergeordnetes Werk:	In: Drug Delivery - Taylor & Francis Group, 2017, 27(2020), 1, Seite 983-995
Übergeordnetes Werk:	volume:27 ; year:2020 ; number:1 ; pages:983-995

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/10717544.2020.1785581

Katalog-ID:	DOAJ05288130X

Internformat


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allfields	10.1080/10717544.2020.1785581 doi (DE-627)DOAJ05288130X (DE-599)DOAJ497a870a554c48599b9d0330fa02a12b DE-627 ger DE-627 rakwb eng RM1-950 Man Xu verfasserin aut Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo. temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release Therapeutics. Pharmacology Guangmeng Li verfasserin aut Haoxiang Zhang verfasserin aut Xiaoming Chen verfasserin aut Yi Li verfasserin aut Qianming Yao verfasserin aut Maobin Xie verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 983-995 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:983-995 https://doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/article/497a870a554c48599b9d0330fa02a12b kostenfrei http://dx.doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 983-995
spelling	10.1080/10717544.2020.1785581 doi (DE-627)DOAJ05288130X (DE-599)DOAJ497a870a554c48599b9d0330fa02a12b DE-627 ger DE-627 rakwb eng RM1-950 Man Xu verfasserin aut Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo. temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release Therapeutics. Pharmacology Guangmeng Li verfasserin aut Haoxiang Zhang verfasserin aut Xiaoming Chen verfasserin aut Yi Li verfasserin aut Qianming Yao verfasserin aut Maobin Xie verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 983-995 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:983-995 https://doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/article/497a870a554c48599b9d0330fa02a12b kostenfrei http://dx.doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 983-995
allfields_unstemmed	10.1080/10717544.2020.1785581 doi (DE-627)DOAJ05288130X (DE-599)DOAJ497a870a554c48599b9d0330fa02a12b DE-627 ger DE-627 rakwb eng RM1-950 Man Xu verfasserin aut Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo. temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release Therapeutics. Pharmacology Guangmeng Li verfasserin aut Haoxiang Zhang verfasserin aut Xiaoming Chen verfasserin aut Yi Li verfasserin aut Qianming Yao verfasserin aut Maobin Xie verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 983-995 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:983-995 https://doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/article/497a870a554c48599b9d0330fa02a12b kostenfrei http://dx.doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 983-995
allfieldsGer	10.1080/10717544.2020.1785581 doi (DE-627)DOAJ05288130X (DE-599)DOAJ497a870a554c48599b9d0330fa02a12b DE-627 ger DE-627 rakwb eng RM1-950 Man Xu verfasserin aut Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo. temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release Therapeutics. Pharmacology Guangmeng Li verfasserin aut Haoxiang Zhang verfasserin aut Xiaoming Chen verfasserin aut Yi Li verfasserin aut Qianming Yao verfasserin aut Maobin Xie verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 983-995 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:983-995 https://doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/article/497a870a554c48599b9d0330fa02a12b kostenfrei http://dx.doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 983-995
allfieldsSound	10.1080/10717544.2020.1785581 doi (DE-627)DOAJ05288130X (DE-599)DOAJ497a870a554c48599b9d0330fa02a12b DE-627 ger DE-627 rakwb eng RM1-950 Man Xu verfasserin aut Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo. temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release Therapeutics. Pharmacology Guangmeng Li verfasserin aut Haoxiang Zhang verfasserin aut Xiaoming Chen verfasserin aut Yi Li verfasserin aut Qianming Yao verfasserin aut Maobin Xie verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 983-995 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:983-995 https://doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/article/497a870a554c48599b9d0330fa02a12b kostenfrei http://dx.doi.org/10.1080/10717544.2020.1785581 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 983-995
language	English
source	In Drug Delivery 27(2020), 1, Seite 983-995 volume:27 year:2020 number:1 pages:983-995
sourceStr	In Drug Delivery 27(2020), 1, Seite 983-995 volume:27 year:2020 number:1 pages:983-995
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Drug Delivery
authorswithroles_txt_mv	Man Xu @@aut@@ Guangmeng Li @@aut@@ Haoxiang Zhang @@aut@@ Xiaoming Chen @@aut@@ Yi Li @@aut@@ Qianming Yao @@aut@@ Maobin Xie @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	320604675
id	DOAJ05288130X
language_de	englisch
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callnumber-first	R - Medicine
author	Man Xu
spellingShingle	Man Xu misc RM1-950 misc temozolomide misc curcumin misc synergistic treatment misc nanostructured lipid carriers misc sequential drug release misc Therapeutics. Pharmacology Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect
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topic_title	RM1-950 Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect temozolomide curcumin synergistic treatment nanostructured lipid carriers sequential drug release
topic	misc RM1-950 misc temozolomide misc curcumin misc synergistic treatment misc nanostructured lipid carriers misc sequential drug release misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc temozolomide misc curcumin misc synergistic treatment misc nanostructured lipid carriers misc sequential drug release misc Therapeutics. Pharmacology
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title	Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect
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title_full	Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect
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author_browse	Man Xu Guangmeng Li Haoxiang Zhang Xiaoming Chen Yi Li Qianming Yao Maobin Xie
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title_sort	sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect
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title_auth	Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect
abstract	To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo.
abstractGer	To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo.
abstract_unstemmed	To improve synergistic anticancer efficacy and minimize the adverse effects of chemotherapeutic drugs, temozolomide (TMZ) and curcumin (CUR) co-loaded nanostructured lipid carriers (NLCs) were prepared by microemulsion in this study. And the physicochemical properties, drug release behavior, intracellular uptake efficiency, in vitro and in vivo anticancer effects of TMZ/CUR-NLCs were evaluated. TMZ/CUR-NLCs showed enhanced inhibitory effects on glioma cells compared to single drug loaded NLCs, which may be owing to that the quickly released CUR can sensitize the cancer cells to TMZ. The inhibitory mechanism is a combination of S phase cell cycle arrest associated with induced apoptosis. Notably, TMZ/CUR-NLCs can accumulate at brain and tumor sites effectively and perform a significant synergistic anticancer effect in vivo. More importantly, the toxic effects of TMZ/CUR-NLCs on major organs and normal cells at the same therapeutic dosage were not observed. In conclusion, NLCs are promising nanocarriers for delivering dual chemotherapeutic drugs sequentially, showing potentials in the synergistic treatment of tumors while reducing adverse effects both in vitro and in vivo.
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title_short	Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect
url	https://doi.org/10.1080/10717544.2020.1785581 https://doaj.org/article/497a870a554c48599b9d0330fa02a12b http://dx.doi.org/10.1080/10717544.2020.1785581 https://doaj.org/toc/1071-7544 https://doaj.org/toc/1521-0464
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Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect

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