Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study

Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cau...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Maya Frank Wolf [verfasserIn] Raneen Abu Shqara [verfasserIn] Karina Naskovica [verfasserIn] Inna Amdur Zilberfarb [verfasserIn] Inshirah Sgayer [verfasserIn] Daniel Glikman [verfasserIn] Hagai Rechnitzer [verfasserIn] Vered Fleisher Sheffer [verfasserIn] Jacob Bornstein [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	extended-spectrum, beta-lactamase-producing maternal colonization preterm birth

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 9(2021), 3, p 506
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:3, p 506

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms9030506

Katalog-ID:	DOAJ053088603

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allfields	10.3390/microorganisms9030506 doi (DE-627)DOAJ053088603 (DE-599)DOAJ8b918df4dd304274b5243a5d091c5471 DE-627 ger DE-627 rakwb eng QH301-705.5 Maya Frank Wolf verfasserin aut Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS. extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< <i<Escherichia coli</i< maternal colonization preterm birth Biology (General) Raneen Abu Shqara verfasserin aut Karina Naskovica verfasserin aut Inna Amdur Zilberfarb verfasserin aut Inshirah Sgayer verfasserin aut Daniel Glikman verfasserin aut Hagai Rechnitzer verfasserin aut Vered Fleisher Sheffer verfasserin aut Jacob Bornstein verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 3, p 506 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:3, p 506 https://doi.org/10.3390/microorganisms9030506 kostenfrei https://doaj.org/article/8b918df4dd304274b5243a5d091c5471 kostenfrei https://www.mdpi.com/2076-2607/9/3/506 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3, p 506
spelling	10.3390/microorganisms9030506 doi (DE-627)DOAJ053088603 (DE-599)DOAJ8b918df4dd304274b5243a5d091c5471 DE-627 ger DE-627 rakwb eng QH301-705.5 Maya Frank Wolf verfasserin aut Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS. extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< <i<Escherichia coli</i< maternal colonization preterm birth Biology (General) Raneen Abu Shqara verfasserin aut Karina Naskovica verfasserin aut Inna Amdur Zilberfarb verfasserin aut Inshirah Sgayer verfasserin aut Daniel Glikman verfasserin aut Hagai Rechnitzer verfasserin aut Vered Fleisher Sheffer verfasserin aut Jacob Bornstein verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 3, p 506 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:3, p 506 https://doi.org/10.3390/microorganisms9030506 kostenfrei https://doaj.org/article/8b918df4dd304274b5243a5d091c5471 kostenfrei https://www.mdpi.com/2076-2607/9/3/506 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3, p 506
allfields_unstemmed	10.3390/microorganisms9030506 doi (DE-627)DOAJ053088603 (DE-599)DOAJ8b918df4dd304274b5243a5d091c5471 DE-627 ger DE-627 rakwb eng QH301-705.5 Maya Frank Wolf verfasserin aut Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS. extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< <i<Escherichia coli</i< maternal colonization preterm birth Biology (General) Raneen Abu Shqara verfasserin aut Karina Naskovica verfasserin aut Inna Amdur Zilberfarb verfasserin aut Inshirah Sgayer verfasserin aut Daniel Glikman verfasserin aut Hagai Rechnitzer verfasserin aut Vered Fleisher Sheffer verfasserin aut Jacob Bornstein verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 3, p 506 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:3, p 506 https://doi.org/10.3390/microorganisms9030506 kostenfrei https://doaj.org/article/8b918df4dd304274b5243a5d091c5471 kostenfrei https://www.mdpi.com/2076-2607/9/3/506 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3, p 506
allfieldsGer	10.3390/microorganisms9030506 doi (DE-627)DOAJ053088603 (DE-599)DOAJ8b918df4dd304274b5243a5d091c5471 DE-627 ger DE-627 rakwb eng QH301-705.5 Maya Frank Wolf verfasserin aut Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS. extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< <i<Escherichia coli</i< maternal colonization preterm birth Biology (General) Raneen Abu Shqara verfasserin aut Karina Naskovica verfasserin aut Inna Amdur Zilberfarb verfasserin aut Inshirah Sgayer verfasserin aut Daniel Glikman verfasserin aut Hagai Rechnitzer verfasserin aut Vered Fleisher Sheffer verfasserin aut Jacob Bornstein verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 3, p 506 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:3, p 506 https://doi.org/10.3390/microorganisms9030506 kostenfrei https://doaj.org/article/8b918df4dd304274b5243a5d091c5471 kostenfrei https://www.mdpi.com/2076-2607/9/3/506 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3, p 506
allfieldsSound	10.3390/microorganisms9030506 doi (DE-627)DOAJ053088603 (DE-599)DOAJ8b918df4dd304274b5243a5d091c5471 DE-627 ger DE-627 rakwb eng QH301-705.5 Maya Frank Wolf verfasserin aut Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS. extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< <i<Escherichia coli</i< maternal colonization preterm birth Biology (General) Raneen Abu Shqara verfasserin aut Karina Naskovica verfasserin aut Inna Amdur Zilberfarb verfasserin aut Inshirah Sgayer verfasserin aut Daniel Glikman verfasserin aut Hagai Rechnitzer verfasserin aut Vered Fleisher Sheffer verfasserin aut Jacob Bornstein verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 3, p 506 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:3, p 506 https://doi.org/10.3390/microorganisms9030506 kostenfrei https://doaj.org/article/8b918df4dd304274b5243a5d091c5471 kostenfrei https://www.mdpi.com/2076-2607/9/3/506 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3, p 506
language	English
source	In Microorganisms 9(2021), 3, p 506 volume:9 year:2021 number:3, p 506
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callnumber-first	Q - Science
author	Maya Frank Wolf
spellingShingle	Maya Frank Wolf misc QH301-705.5 misc extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< misc <i<Escherichia coli</i< misc maternal colonization misc preterm birth misc Biology (General) Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study
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topic_title	QH301-705.5 Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< <i<Escherichia coli</i< maternal colonization preterm birth
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title	Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study
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title_full	Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study
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title_sort	vertical transmission of extended-spectrum, beta-lactamase-producing <i<enterobacteriaceae</i< during preterm delivery: a prospective study
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title_auth	Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study
abstract	Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS.
abstractGer	Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS.
abstract_unstemmed	Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing <i<Enterobacteriaceae</i< (ESBL-E), such as <i<Escherichia coli</i<, hamper the treatment of infections, resulting in high morbidity. <i<E. coli</i< is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (<i<p</i< = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS.
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title_short	Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study
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Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing <i<Enterobacteriaceae</i< during Preterm Delivery: A Prospective Study

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