Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach

Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation an...
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Gespeichert in:

Autor*in:	Srdjan Gavrilovic [verfasserIn] Ana Andrijevic [verfasserIn] Aida Mujakovic [verfasserIn] Yewande Odeyemi [verfasserIn] Belma Paralija [verfasserIn] Ognjen Gajic [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Pneumonia corticosteroids C-reactive protein biomarkers intensive care unit ICU

Übergeordnetes Werk:	In: Bosnian Journal of Basic Medical Sciences - Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2010, (2019)
Übergeordnetes Werk:	year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.17305/bjbms.2019.3977

Katalog-ID:	DOAJ053259726

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spelling	10.17305/bjbms.2019.3977 doi (DE-627)DOAJ053259726 (DE-599)DOAJ5f8b4d40ad21432a8227f4bc949c4e23 DE-627 ger DE-627 rakwb eng R5-920 Srdjan Gavrilovic verfasserin aut Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation. Pneumonia corticosteroids C-reactive protein biomarkers intensive care unit ICU Medicine (General) Ana Andrijevic verfasserin aut Aida Mujakovic verfasserin aut Yewande Odeyemi verfasserin aut Belma Paralija verfasserin aut Ognjen Gajic verfasserin aut In Bosnian Journal of Basic Medical Sciences Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2010 (2019) (DE-627)624252752 (DE-600)2548947-1 15128601 nnns year:2019 https://doi.org/10.17305/bjbms.2019.3977 kostenfrei https://doaj.org/article/5f8b4d40ad21432a8227f4bc949c4e23 kostenfrei http://bjbms.org/ojs/index.php/bjbms/article/view/3977 kostenfrei https://doaj.org/toc/1512-8601 Journal toc kostenfrei https://doaj.org/toc/1840-4812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
allfields_unstemmed	10.17305/bjbms.2019.3977 doi (DE-627)DOAJ053259726 (DE-599)DOAJ5f8b4d40ad21432a8227f4bc949c4e23 DE-627 ger DE-627 rakwb eng R5-920 Srdjan Gavrilovic verfasserin aut Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation. Pneumonia corticosteroids C-reactive protein biomarkers intensive care unit ICU Medicine (General) Ana Andrijevic verfasserin aut Aida Mujakovic verfasserin aut Yewande Odeyemi verfasserin aut Belma Paralija verfasserin aut Ognjen Gajic verfasserin aut In Bosnian Journal of Basic Medical Sciences Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2010 (2019) (DE-627)624252752 (DE-600)2548947-1 15128601 nnns year:2019 https://doi.org/10.17305/bjbms.2019.3977 kostenfrei https://doaj.org/article/5f8b4d40ad21432a8227f4bc949c4e23 kostenfrei http://bjbms.org/ojs/index.php/bjbms/article/view/3977 kostenfrei https://doaj.org/toc/1512-8601 Journal toc kostenfrei https://doaj.org/toc/1840-4812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
allfieldsGer	10.17305/bjbms.2019.3977 doi (DE-627)DOAJ053259726 (DE-599)DOAJ5f8b4d40ad21432a8227f4bc949c4e23 DE-627 ger DE-627 rakwb eng R5-920 Srdjan Gavrilovic verfasserin aut Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation. Pneumonia corticosteroids C-reactive protein biomarkers intensive care unit ICU Medicine (General) Ana Andrijevic verfasserin aut Aida Mujakovic verfasserin aut Yewande Odeyemi verfasserin aut Belma Paralija verfasserin aut Ognjen Gajic verfasserin aut In Bosnian Journal of Basic Medical Sciences Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2010 (2019) (DE-627)624252752 (DE-600)2548947-1 15128601 nnns year:2019 https://doi.org/10.17305/bjbms.2019.3977 kostenfrei https://doaj.org/article/5f8b4d40ad21432a8227f4bc949c4e23 kostenfrei http://bjbms.org/ojs/index.php/bjbms/article/view/3977 kostenfrei https://doaj.org/toc/1512-8601 Journal toc kostenfrei https://doaj.org/toc/1840-4812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
allfieldsSound	10.17305/bjbms.2019.3977 doi (DE-627)DOAJ053259726 (DE-599)DOAJ5f8b4d40ad21432a8227f4bc949c4e23 DE-627 ger DE-627 rakwb eng R5-920 Srdjan Gavrilovic verfasserin aut Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation. Pneumonia corticosteroids C-reactive protein biomarkers intensive care unit ICU Medicine (General) Ana Andrijevic verfasserin aut Aida Mujakovic verfasserin aut Yewande Odeyemi verfasserin aut Belma Paralija verfasserin aut Ognjen Gajic verfasserin aut In Bosnian Journal of Basic Medical Sciences Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2010 (2019) (DE-627)624252752 (DE-600)2548947-1 15128601 nnns year:2019 https://doi.org/10.17305/bjbms.2019.3977 kostenfrei https://doaj.org/article/5f8b4d40ad21432a8227f4bc949c4e23 kostenfrei http://bjbms.org/ojs/index.php/bjbms/article/view/3977 kostenfrei https://doaj.org/toc/1512-8601 Journal toc kostenfrei https://doaj.org/toc/1840-4812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
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author	Srdjan Gavrilovic
spellingShingle	Srdjan Gavrilovic misc R5-920 misc Pneumonia misc corticosteroids misc C-reactive protein misc biomarkers misc intensive care unit misc ICU misc Medicine (General) Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach
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topic_title	R5-920 Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach Pneumonia corticosteroids C-reactive protein biomarkers intensive care unit ICU
topic	misc R5-920 misc Pneumonia misc corticosteroids misc C-reactive protein misc biomarkers misc intensive care unit misc ICU misc Medicine (General)
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title_sort	adjunct corticosteroid treatment in patients with pneumonia: a precision medicine approach
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title_auth	Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach
abstract	Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation.
abstractGer	Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation.
abstract_unstemmed	Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation.
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title_short	Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach
url	https://doi.org/10.17305/bjbms.2019.3977 https://doaj.org/article/5f8b4d40ad21432a8227f4bc949c4e23 http://bjbms.org/ojs/index.php/bjbms/article/view/3977 https://doaj.org/toc/1512-8601 https://doaj.org/toc/1840-4812
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