Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study

Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly deplete...
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Gespeichert in:

Autor*in:	Barbara Olendzki [verfasserIn] Vanni Bucci [verfasserIn] Caitlin Cawley [verfasserIn] Rene Maserati [verfasserIn] Margaret McManus [verfasserIn] Effie Olednzki [verfasserIn] Camilla Madziar [verfasserIn] David Chiang [verfasserIn] Doyle V. Ward [verfasserIn] Randall Pellish [verfasserIn] Christine Foley [verfasserIn] Shakti Bhattarai [verfasserIn] Beth A. McCormick [verfasserIn] Ana Maldonado-Contreras [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Microbiome IBD diet dysbiosis

Übergeordnetes Werk:	In: Gut Microbes - Taylor & Francis Group, 2020, 14(2022), 1
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/19490976.2022.2046244

Katalog-ID:	DOAJ053295218

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spelling	10.1080/19490976.2022.2046244 doi (DE-627)DOAJ053295218 (DE-599)DOAJ5d95e708aab6452a87a743318ce4186e DE-627 ger DE-627 rakwb eng RC799-869 Barbara Olendzki verfasserin aut Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. We further show that specific foods categorized as prebiotics or adverse foods are correlated to levels of cytokines in serum (i.e., GM-CSF, IL-6, IL-8, TNF-alpha) that play a central role in IBD pathogenesis. By using robust predictive analytics, this study represents the first steps to detangle diet-microbiome and diet-immune interactions to inform personalized nutrition for patients suffering from dysbiosis-related IBD. Microbiome IBD diet dysbiosis Diseases of the digestive system. Gastroenterology Vanni Bucci verfasserin aut Caitlin Cawley verfasserin aut Rene Maserati verfasserin aut Margaret McManus verfasserin aut Effie Olednzki verfasserin aut Camilla Madziar verfasserin aut David Chiang verfasserin aut Doyle V. Ward verfasserin aut Randall Pellish verfasserin aut Christine Foley verfasserin aut Shakti Bhattarai verfasserin aut Beth A. McCormick verfasserin aut Ana Maldonado-Contreras verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 14(2022), 1 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:14 year:2022 number:1 https://doi.org/10.1080/19490976.2022.2046244 kostenfrei https://doaj.org/article/5d95e708aab6452a87a743318ce4186e kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2022.2046244 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1
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allfieldsGer	10.1080/19490976.2022.2046244 doi (DE-627)DOAJ053295218 (DE-599)DOAJ5d95e708aab6452a87a743318ce4186e DE-627 ger DE-627 rakwb eng RC799-869 Barbara Olendzki verfasserin aut Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. We further show that specific foods categorized as prebiotics or adverse foods are correlated to levels of cytokines in serum (i.e., GM-CSF, IL-6, IL-8, TNF-alpha) that play a central role in IBD pathogenesis. By using robust predictive analytics, this study represents the first steps to detangle diet-microbiome and diet-immune interactions to inform personalized nutrition for patients suffering from dysbiosis-related IBD. Microbiome IBD diet dysbiosis Diseases of the digestive system. Gastroenterology Vanni Bucci verfasserin aut Caitlin Cawley verfasserin aut Rene Maserati verfasserin aut Margaret McManus verfasserin aut Effie Olednzki verfasserin aut Camilla Madziar verfasserin aut David Chiang verfasserin aut Doyle V. Ward verfasserin aut Randall Pellish verfasserin aut Christine Foley verfasserin aut Shakti Bhattarai verfasserin aut Beth A. McCormick verfasserin aut Ana Maldonado-Contreras verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 14(2022), 1 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:14 year:2022 number:1 https://doi.org/10.1080/19490976.2022.2046244 kostenfrei https://doaj.org/article/5d95e708aab6452a87a743318ce4186e kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2022.2046244 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1
allfieldsSound	10.1080/19490976.2022.2046244 doi (DE-627)DOAJ053295218 (DE-599)DOAJ5d95e708aab6452a87a743318ce4186e DE-627 ger DE-627 rakwb eng RC799-869 Barbara Olendzki verfasserin aut Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. We further show that specific foods categorized as prebiotics or adverse foods are correlated to levels of cytokines in serum (i.e., GM-CSF, IL-6, IL-8, TNF-alpha) that play a central role in IBD pathogenesis. By using robust predictive analytics, this study represents the first steps to detangle diet-microbiome and diet-immune interactions to inform personalized nutrition for patients suffering from dysbiosis-related IBD. Microbiome IBD diet dysbiosis Diseases of the digestive system. Gastroenterology Vanni Bucci verfasserin aut Caitlin Cawley verfasserin aut Rene Maserati verfasserin aut Margaret McManus verfasserin aut Effie Olednzki verfasserin aut Camilla Madziar verfasserin aut David Chiang verfasserin aut Doyle V. Ward verfasserin aut Randall Pellish verfasserin aut Christine Foley verfasserin aut Shakti Bhattarai verfasserin aut Beth A. McCormick verfasserin aut Ana Maldonado-Contreras verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 14(2022), 1 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:14 year:2022 number:1 https://doi.org/10.1080/19490976.2022.2046244 kostenfrei https://doaj.org/article/5d95e708aab6452a87a743318ce4186e kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2022.2046244 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1
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callnumber-first	R - Medicine
author	Barbara Olendzki
spellingShingle	Barbara Olendzki misc RC799-869 misc Microbiome misc IBD misc diet misc dysbiosis misc Diseases of the digestive system. Gastroenterology Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study
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topic_title	RC799-869 Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study Microbiome IBD diet dysbiosis
topic	misc RC799-869 misc Microbiome misc IBD misc diet misc dysbiosis misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc Microbiome misc IBD misc diet misc dysbiosis misc Diseases of the digestive system. Gastroenterology
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title	Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study
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title_sort	dietary manipulation of the gut microbiome in inflammatory bowel disease patients: pilot study
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title_auth	Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study
abstract	Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. We further show that specific foods categorized as prebiotics or adverse foods are correlated to levels of cytokines in serum (i.e., GM-CSF, IL-6, IL-8, TNF-alpha) that play a central role in IBD pathogenesis. By using robust predictive analytics, this study represents the first steps to detangle diet-microbiome and diet-immune interactions to inform personalized nutrition for patients suffering from dysbiosis-related IBD.
abstractGer	Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. We further show that specific foods categorized as prebiotics or adverse foods are correlated to levels of cytokines in serum (i.e., GM-CSF, IL-6, IL-8, TNF-alpha) that play a central role in IBD pathogenesis. By using robust predictive analytics, this study represents the first steps to detangle diet-microbiome and diet-immune interactions to inform personalized nutrition for patients suffering from dysbiosis-related IBD.
abstract_unstemmed	Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinal microbiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. We further show that specific foods categorized as prebiotics or adverse foods are correlated to levels of cytokines in serum (i.e., GM-CSF, IL-6, IL-8, TNF-alpha) that play a central role in IBD pathogenesis. By using robust predictive analytics, this study represents the first steps to detangle diet-microbiome and diet-immune interactions to inform personalized nutrition for patients suffering from dysbiosis-related IBD.
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title_short	Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study
url	https://doi.org/10.1080/19490976.2022.2046244 https://doaj.org/article/5d95e708aab6452a87a743318ce4186e https://www.tandfonline.com/doi/10.1080/19490976.2022.2046244 https://doaj.org/toc/1949-0976 https://doaj.org/toc/1949-0984
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A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linked to inflammation. Here, we aim to define the impact of specific foods on bacterial species commonly depleted in patients with IBD to better inform dietary treatment. We performed a single-arm, pre-post intervention trial. After a baseline period, a dietary intervention with the IBD-Anti-Inflammatory Diet (IBD-AID) was initiated. We collected stool and blood samples and assessed dietary intake throughout the study. We applied advanced computational approaches to define and model complex interactions between the foods reported and the microbiome. A dense dataset comprising 553 dietary records and 340 stool samples was obtained from 22 participants. Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. 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Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study

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