Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study

Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ tha...
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Gespeichert in:

Autor*in:	Kohei Okuyama [verfasserIn] Saki Hayashida [verfasserIn] Satoshi Rokutanda [verfasserIn] Akiko Kawakita [verfasserIn] Sakiko Soutome [verfasserIn] Shunsuke Sawada [verfasserIn] Souichi Yanamoto [verfasserIn] Yuka Kojima [verfasserIn] Masahiro Umeda [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Medication-related osteonecrosis of the jaw Maxilla Necrotic bone Extensive surgery Maxillary sinusitis

Übergeordnetes Werk:	In: Journal of Dental Sciences - Elsevier, 2017, 16(2021), 3, Seite 885-890
Übergeordnetes Werk:	volume:16 ; year:2021 ; number:3 ; pages:885-890

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jds.2020.12.007

Katalog-ID:	DOAJ05342252X

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allfields	10.1016/j.jds.2020.12.007 doi (DE-627)DOAJ05342252X (DE-599)DOAJe1d6edbfe1254f72b0b773c3dd1ea569 DE-627 ger DE-627 rakwb eng RK1-715 Kohei Okuyama verfasserin aut Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes. Materials and methods: The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms. Results: The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement. Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ. Medication-related osteonecrosis of the jaw Maxilla Necrotic bone Extensive surgery Maxillary sinusitis Dentistry Saki Hayashida verfasserin aut Satoshi Rokutanda verfasserin aut Akiko Kawakita verfasserin aut Sakiko Soutome verfasserin aut Shunsuke Sawada verfasserin aut Souichi Yanamoto verfasserin aut Yuka Kojima verfasserin aut Masahiro Umeda verfasserin aut In Journal of Dental Sciences Elsevier, 2017 16(2021), 3, Seite 885-890 (DE-627)604074778 (DE-600)2502332-9 19917902 nnns volume:16 year:2021 number:3 pages:885-890 https://doi.org/10.1016/j.jds.2020.12.007 kostenfrei https://doaj.org/article/e1d6edbfe1254f72b0b773c3dd1ea569 kostenfrei http://www.sciencedirect.com/science/article/pii/S1991790220302841 kostenfrei https://doaj.org/toc/1991-7902 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3 885-890
spelling	10.1016/j.jds.2020.12.007 doi (DE-627)DOAJ05342252X (DE-599)DOAJe1d6edbfe1254f72b0b773c3dd1ea569 DE-627 ger DE-627 rakwb eng RK1-715 Kohei Okuyama verfasserin aut Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes. Materials and methods: The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms. Results: The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement. Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ. Medication-related osteonecrosis of the jaw Maxilla Necrotic bone Extensive surgery Maxillary sinusitis Dentistry Saki Hayashida verfasserin aut Satoshi Rokutanda verfasserin aut Akiko Kawakita verfasserin aut Sakiko Soutome verfasserin aut Shunsuke Sawada verfasserin aut Souichi Yanamoto verfasserin aut Yuka Kojima verfasserin aut Masahiro Umeda verfasserin aut In Journal of Dental Sciences Elsevier, 2017 16(2021), 3, Seite 885-890 (DE-627)604074778 (DE-600)2502332-9 19917902 nnns volume:16 year:2021 number:3 pages:885-890 https://doi.org/10.1016/j.jds.2020.12.007 kostenfrei https://doaj.org/article/e1d6edbfe1254f72b0b773c3dd1ea569 kostenfrei http://www.sciencedirect.com/science/article/pii/S1991790220302841 kostenfrei https://doaj.org/toc/1991-7902 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3 885-890
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allfieldsGer	10.1016/j.jds.2020.12.007 doi (DE-627)DOAJ05342252X (DE-599)DOAJe1d6edbfe1254f72b0b773c3dd1ea569 DE-627 ger DE-627 rakwb eng RK1-715 Kohei Okuyama verfasserin aut Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes. Materials and methods: The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms. Results: The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement. Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ. Medication-related osteonecrosis of the jaw Maxilla Necrotic bone Extensive surgery Maxillary sinusitis Dentistry Saki Hayashida verfasserin aut Satoshi Rokutanda verfasserin aut Akiko Kawakita verfasserin aut Sakiko Soutome verfasserin aut Shunsuke Sawada verfasserin aut Souichi Yanamoto verfasserin aut Yuka Kojima verfasserin aut Masahiro Umeda verfasserin aut In Journal of Dental Sciences Elsevier, 2017 16(2021), 3, Seite 885-890 (DE-627)604074778 (DE-600)2502332-9 19917902 nnns volume:16 year:2021 number:3 pages:885-890 https://doi.org/10.1016/j.jds.2020.12.007 kostenfrei https://doaj.org/article/e1d6edbfe1254f72b0b773c3dd1ea569 kostenfrei http://www.sciencedirect.com/science/article/pii/S1991790220302841 kostenfrei https://doaj.org/toc/1991-7902 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3 885-890
allfieldsSound	10.1016/j.jds.2020.12.007 doi (DE-627)DOAJ05342252X (DE-599)DOAJe1d6edbfe1254f72b0b773c3dd1ea569 DE-627 ger DE-627 rakwb eng RK1-715 Kohei Okuyama verfasserin aut Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes. Materials and methods: The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms. Results: The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement. Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ. Medication-related osteonecrosis of the jaw Maxilla Necrotic bone Extensive surgery Maxillary sinusitis Dentistry Saki Hayashida verfasserin aut Satoshi Rokutanda verfasserin aut Akiko Kawakita verfasserin aut Sakiko Soutome verfasserin aut Shunsuke Sawada verfasserin aut Souichi Yanamoto verfasserin aut Yuka Kojima verfasserin aut Masahiro Umeda verfasserin aut In Journal of Dental Sciences Elsevier, 2017 16(2021), 3, Seite 885-890 (DE-627)604074778 (DE-600)2502332-9 19917902 nnns volume:16 year:2021 number:3 pages:885-890 https://doi.org/10.1016/j.jds.2020.12.007 kostenfrei https://doaj.org/article/e1d6edbfe1254f72b0b773c3dd1ea569 kostenfrei http://www.sciencedirect.com/science/article/pii/S1991790220302841 kostenfrei https://doaj.org/toc/1991-7902 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3 885-890
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author	Kohei Okuyama
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topic_title	RK1-715 Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study Medication-related osteonecrosis of the jaw Maxilla Necrotic bone Extensive surgery Maxillary sinusitis
topic	misc RK1-715 misc Medication-related osteonecrosis of the jaw misc Maxilla misc Necrotic bone misc Extensive surgery misc Maxillary sinusitis misc Dentistry
topic_unstemmed	misc RK1-715 misc Medication-related osteonecrosis of the jaw misc Maxilla misc Necrotic bone misc Extensive surgery misc Maxillary sinusitis misc Dentistry
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title	Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study
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title_full	Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study
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title_sort	surgical strategy for medication-related osteonecrosis of the jaw (mronj) on maxilla: a multicenter retrospective study
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title_auth	Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study
abstract	Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes. Materials and methods: The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms. Results: The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement. Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ.
abstractGer	Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes. Materials and methods: The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms. Results: The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement. Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ.
abstract_unstemmed	Background/purpose: Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes. Materials and methods: The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms. Results: The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement. Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ.
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title_short	Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study
url	https://doi.org/10.1016/j.jds.2020.12.007 https://doaj.org/article/e1d6edbfe1254f72b0b773c3dd1ea569 http://www.sciencedirect.com/science/article/pii/S1991790220302841 https://doaj.org/toc/1991-7902
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Conclusion: Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. 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Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study

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