Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma

Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gl...
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Autor*in:	DING Gaofeng [verfasserIn] GUO Leiming [verfasserIn] KE Shaorui [verfasserIn] LU Yufei [verfasserIn]

Format:	E-Artikel
Sprache:	Chinesisch

Erschienen:	2021

Schlagwörter:	pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin

Übergeordnetes Werk:	In: Zhongliu Fangzhi Yanjiu - Magazine House of Cancer Research on Prevention and Treatment, 2019, 48(2021), 5, Seite 470-473
Übergeordnetes Werk:	volume:48 ; year:2021 ; number:5 ; pages:470-473

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3971/j.issn.1000-8578.2021.20.0923

Katalog-ID:	DOAJ053438248

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245	1	0	\|a Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma
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520			\|a Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors.
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allfields	10.3971/j.issn.1000-8578.2021.20.0923 doi (DE-627)DOAJ053438248 (DE-599)DOAJ4c618315fb6344958124f4dc7e1dcece DE-627 ger DE-627 rakwb chi RC254-282 DING Gaofeng verfasserin aut Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors. pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin Neoplasms. Tumors. Oncology. Including cancer and carcinogens GUO Leiming verfasserin aut KE Shaorui verfasserin aut LU Yufei verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 48(2021), 5, Seite 470-473 (DE-627)176063638X 10008578 nnns volume:48 year:2021 number:5 pages:470-473 https://doi.org/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/article/4c618315fb6344958124f4dc7e1dcece kostenfrei http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 48 2021 5 470-473
spelling	10.3971/j.issn.1000-8578.2021.20.0923 doi (DE-627)DOAJ053438248 (DE-599)DOAJ4c618315fb6344958124f4dc7e1dcece DE-627 ger DE-627 rakwb chi RC254-282 DING Gaofeng verfasserin aut Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors. pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin Neoplasms. Tumors. Oncology. Including cancer and carcinogens GUO Leiming verfasserin aut KE Shaorui verfasserin aut LU Yufei verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 48(2021), 5, Seite 470-473 (DE-627)176063638X 10008578 nnns volume:48 year:2021 number:5 pages:470-473 https://doi.org/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/article/4c618315fb6344958124f4dc7e1dcece kostenfrei http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 48 2021 5 470-473
allfields_unstemmed	10.3971/j.issn.1000-8578.2021.20.0923 doi (DE-627)DOAJ053438248 (DE-599)DOAJ4c618315fb6344958124f4dc7e1dcece DE-627 ger DE-627 rakwb chi RC254-282 DING Gaofeng verfasserin aut Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors. pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin Neoplasms. Tumors. Oncology. Including cancer and carcinogens GUO Leiming verfasserin aut KE Shaorui verfasserin aut LU Yufei verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 48(2021), 5, Seite 470-473 (DE-627)176063638X 10008578 nnns volume:48 year:2021 number:5 pages:470-473 https://doi.org/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/article/4c618315fb6344958124f4dc7e1dcece kostenfrei http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 48 2021 5 470-473
allfieldsGer	10.3971/j.issn.1000-8578.2021.20.0923 doi (DE-627)DOAJ053438248 (DE-599)DOAJ4c618315fb6344958124f4dc7e1dcece DE-627 ger DE-627 rakwb chi RC254-282 DING Gaofeng verfasserin aut Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors. pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin Neoplasms. Tumors. Oncology. Including cancer and carcinogens GUO Leiming verfasserin aut KE Shaorui verfasserin aut LU Yufei verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 48(2021), 5, Seite 470-473 (DE-627)176063638X 10008578 nnns volume:48 year:2021 number:5 pages:470-473 https://doi.org/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/article/4c618315fb6344958124f4dc7e1dcece kostenfrei http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 48 2021 5 470-473
allfieldsSound	10.3971/j.issn.1000-8578.2021.20.0923 doi (DE-627)DOAJ053438248 (DE-599)DOAJ4c618315fb6344958124f4dc7e1dcece DE-627 ger DE-627 rakwb chi RC254-282 DING Gaofeng verfasserin aut Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors. pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin Neoplasms. Tumors. Oncology. Including cancer and carcinogens GUO Leiming verfasserin aut KE Shaorui verfasserin aut LU Yufei verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 48(2021), 5, Seite 470-473 (DE-627)176063638X 10008578 nnns volume:48 year:2021 number:5 pages:470-473 https://doi.org/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/article/4c618315fb6344958124f4dc7e1dcece kostenfrei http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.20.0923 kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 48 2021 5 470-473
language	Chinese
source	In Zhongliu Fangzhi Yanjiu 48(2021), 5, Seite 470-473 volume:48 year:2021 number:5 pages:470-473
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topic_facet	pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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callnumber-first	R - Medicine
author	DING Gaofeng
spellingShingle	DING Gaofeng misc RC254-282 misc pleomorphic adenoma misc carcinoma in pleomorphic adenoma misc mitochondrial autophagy misc pink1 misc parkin misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma
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topic_title	RC254-282 Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma pleomorphic adenoma carcinoma in pleomorphic adenoma mitochondrial autophagy pink1 parkin
topic	misc RC254-282 misc pleomorphic adenoma misc carcinoma in pleomorphic adenoma misc mitochondrial autophagy misc pink1 misc parkin misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc pleomorphic adenoma misc carcinoma in pleomorphic adenoma misc mitochondrial autophagy misc pink1 misc parkin misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc pleomorphic adenoma misc carcinoma in pleomorphic adenoma misc mitochondrial autophagy misc pink1 misc parkin misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma
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title_full	Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma
author_sort	DING Gaofeng
journal	Zhongliu Fangzhi Yanjiu
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author_browse	DING Gaofeng GUO Leiming KE Shaorui LU Yufei
container_volume	48
class	RC254-282
format_se	Elektronische Aufsätze
author-letter	DING Gaofeng
doi_str_mv	10.3971/j.issn.1000-8578.2021.20.0923
author2-role	verfasserin
title_sort	expression and significance of mitochondrial autophagy-associated protein pink1 and parkin in parotid pleomorphic adenoma and carcinoma ex pleomorphic adenoma
callnumber	RC254-282
title_auth	Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma
abstract	Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors.
abstractGer	Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors.
abstract_unstemmed	Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA). Methods The expression of PINK1 and Parkin were detected by immunohistochemistry in 24 cases of normal parotid gland tissues, 32 cases of PA tissues and 42 cases of CA-EX-PA tissues. The correlations of PINK1 and Parkin expression with the clinicopathologic characteristics of CA-EX-PA patients were analyzed. Results The positive rates of PINK1 in normal parotid gland, PA and CA-EX-PA tissues were 100%, 91% and 67% respectively; and those of Parkin were 100%, 88% and 52% respectively. The expression rates of PINK1 and Parkin in PA and CA-EX-PA tissues were significantly lower than those in normal tissues (P < 0.05). The expression of PINK1 and Parkin protein were positively correlated in CA-EX-PA tissues (r=0.877, P < 0.01). In CA-EX-PA tissues, the expression of PINK1 and Parkin were associated with tumor invasion, lymph node metastasis and TNM stage (P < 0.05). Conclusion The expression of PINK1 and Parkin are decreased in PA and CA-EX-PA tissues. The decrease of mitochondrial autophagy activity might play important roles in the development, invasion and metastasis of parotid gland tumors.
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title_short	Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma
url	https://doi.org/10.3971/j.issn.1000-8578.2021.20.0923 https://doaj.org/article/4c618315fb6344958124f4dc7e1dcece http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.20.0923 https://doaj.org/toc/1000-8578
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author2	GUO Leiming KE Shaorui LU Yufei
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callnumber-a	RC254-282
up_date	2024-07-03T17:40:10.694Z
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Expression and Significance of Mitochondrial Autophagy-associated Protein PINK1 and Parkin in Parotid Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma

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