Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells

Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in test...
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Autor*in:	Hung Manh Phung [verfasserIn] Sullim Lee [verfasserIn] Ji Hye Hwang [verfasserIn] Ki Sung Kang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	muscone cisplatin nephrotoxicity acute kidney injury LLC-PK1 chromatin condensation

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 10(2020), 10, p 1444
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:10, p 1444

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom10101444

Katalog-ID:	DOAJ053705343

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520			\|a Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity.
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spelling	10.3390/biom10101444 doi (DE-627)DOAJ053705343 (DE-599)DOAJ471cc5d02c6e44d3b1902f088c0a97c1 DE-627 ger DE-627 rakwb eng QR1-502 Hung Manh Phung verfasserin aut Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity. muscone cisplatin nephrotoxicity acute kidney injury LLC-PK1 chromatin condensation Microbiology Sullim Lee verfasserin aut Ji Hye Hwang verfasserin aut Ki Sung Kang verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 10, p 1444 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:10, p 1444 https://doi.org/10.3390/biom10101444 kostenfrei https://doaj.org/article/471cc5d02c6e44d3b1902f088c0a97c1 kostenfrei https://www.mdpi.com/2218-273X/10/10/1444 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 10, p 1444
allfields_unstemmed	10.3390/biom10101444 doi (DE-627)DOAJ053705343 (DE-599)DOAJ471cc5d02c6e44d3b1902f088c0a97c1 DE-627 ger DE-627 rakwb eng QR1-502 Hung Manh Phung verfasserin aut Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity. muscone cisplatin nephrotoxicity acute kidney injury LLC-PK1 chromatin condensation Microbiology Sullim Lee verfasserin aut Ji Hye Hwang verfasserin aut Ki Sung Kang verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 10, p 1444 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:10, p 1444 https://doi.org/10.3390/biom10101444 kostenfrei https://doaj.org/article/471cc5d02c6e44d3b1902f088c0a97c1 kostenfrei https://www.mdpi.com/2218-273X/10/10/1444 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 10, p 1444
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allfieldsSound	10.3390/biom10101444 doi (DE-627)DOAJ053705343 (DE-599)DOAJ471cc5d02c6e44d3b1902f088c0a97c1 DE-627 ger DE-627 rakwb eng QR1-502 Hung Manh Phung verfasserin aut Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity. muscone cisplatin nephrotoxicity acute kidney injury LLC-PK1 chromatin condensation Microbiology Sullim Lee verfasserin aut Ji Hye Hwang verfasserin aut Ki Sung Kang verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 10, p 1444 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:10, p 1444 https://doi.org/10.3390/biom10101444 kostenfrei https://doaj.org/article/471cc5d02c6e44d3b1902f088c0a97c1 kostenfrei https://www.mdpi.com/2218-273X/10/10/1444 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 10, p 1444
language	English
source	In Biomolecules 10(2020), 10, p 1444 volume:10 year:2020 number:10, p 1444
sourceStr	In Biomolecules 10(2020), 10, p 1444 volume:10 year:2020 number:10, p 1444
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	muscone cisplatin nephrotoxicity acute kidney injury LLC-PK1 chromatin condensation Microbiology
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container_title	Biomolecules
authorswithroles_txt_mv	Hung Manh Phung @@aut@@ Sullim Lee @@aut@@ Ji Hye Hwang @@aut@@ Ki Sung Kang @@aut@@
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callnumber-first	Q - Science
author	Hung Manh Phung
spellingShingle	Hung Manh Phung misc QR1-502 misc muscone misc cisplatin misc nephrotoxicity misc acute kidney injury misc LLC-PK1 misc chromatin condensation misc Microbiology Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells
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topic_title	QR1-502 Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells muscone cisplatin nephrotoxicity acute kidney injury LLC-PK1 chromatin condensation
topic	misc QR1-502 misc muscone misc cisplatin misc nephrotoxicity misc acute kidney injury misc LLC-PK1 misc chromatin condensation misc Microbiology
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title	Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells
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title_full	Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells
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title_sort	preventive effect of muscone against cisplatin nephrotoxicity in llc-pk1 cells
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title_auth	Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells
abstract	Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity.
abstractGer	Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity.
abstract_unstemmed	Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity.
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title_short	Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells
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