Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019

Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cel...
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Autor*in:	Christian Zanza [verfasserIn] Michele Fidel Tassi [verfasserIn] Tatsiana Romenskaya [verfasserIn] Fabio Piccolella [verfasserIn] Ludovico Abenavoli [verfasserIn] Francesco Franceschi [verfasserIn] Andrea Piccioni [verfasserIn] Veronica Ojetti [verfasserIn] Angela Saviano [verfasserIn] Barbara Canonico [verfasserIn] Mariele Montanari [verfasserIn] Loris Zamai [verfasserIn] Marco Artico [verfasserIn] Chiara Robba [verfasserIn] Fabrizio Racca [verfasserIn] Yaroslava Longhitano [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	COVID-19 SARS-CoV2 ACE2 renin-angiotensin-aldosterone system ACE inhibitors sartans

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 10(2021), 7, p 1752
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:7, p 1752

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells10071752

Katalog-ID:	DOAJ053801059

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authorswithroles_txt_mv	Christian Zanza @@aut@@ Michele Fidel Tassi @@aut@@ Tatsiana Romenskaya @@aut@@ Fabio Piccolella @@aut@@ Ludovico Abenavoli @@aut@@ Francesco Franceschi @@aut@@ Andrea Piccioni @@aut@@ Veronica Ojetti @@aut@@ Angela Saviano @@aut@@ Barbara Canonico @@aut@@ Mariele Montanari @@aut@@ Loris Zamai @@aut@@ Marco Artico @@aut@@ Chiara Robba @@aut@@ Fabrizio Racca @@aut@@ Yaroslava Longhitano @@aut@@
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callnumber-first	Q - Science
author	Christian Zanza
spellingShingle	Christian Zanza misc QH573-671 misc COVID-19 misc SARS-CoV2 misc ACE2 misc renin-angiotensin-aldosterone system misc ACE inhibitors misc sartans misc Cytology Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019
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topic_title	QH573-671 Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019 COVID-19 SARS-CoV2 ACE2 renin-angiotensin-aldosterone system ACE inhibitors sartans
topic	misc QH573-671 misc COVID-19 misc SARS-CoV2 misc ACE2 misc renin-angiotensin-aldosterone system misc ACE inhibitors misc sartans misc Cytology
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title	Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019
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abstract	Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cells of our body, it was hypothesized that the renin-angiotensin-aldosterone system was involved in the pathogenesis of the disease. Since then, numerous studies have been published on the subject, but the exact role of the renin-angiotensin-aldosterone system in the pathogenesis of COVID-19 is still a matter of debate. RAAS represents an important protagonist in the pathogenesis of COVID-19, providing the virus with the receptor of entry into host cells and determining its organotropism. Furthermore, following infection, the virus is able to cause an increase in plasma ACE2 activity, compromising the normal function of the RAAS. This dysfunction could contribute to the establishment of the thrombo-inflammatory state characteristic of severe forms of COVID-19. Drugs targeting RAAS represent promising therapeutic options for COVID-19 sufferers.
abstractGer	Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cells of our body, it was hypothesized that the renin-angiotensin-aldosterone system was involved in the pathogenesis of the disease. Since then, numerous studies have been published on the subject, but the exact role of the renin-angiotensin-aldosterone system in the pathogenesis of COVID-19 is still a matter of debate. RAAS represents an important protagonist in the pathogenesis of COVID-19, providing the virus with the receptor of entry into host cells and determining its organotropism. Furthermore, following infection, the virus is able to cause an increase in plasma ACE2 activity, compromising the normal function of the RAAS. This dysfunction could contribute to the establishment of the thrombo-inflammatory state characteristic of severe forms of COVID-19. Drugs targeting RAAS represent promising therapeutic options for COVID-19 sufferers.
abstract_unstemmed	Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cells of our body, it was hypothesized that the renin-angiotensin-aldosterone system was involved in the pathogenesis of the disease. Since then, numerous studies have been published on the subject, but the exact role of the renin-angiotensin-aldosterone system in the pathogenesis of COVID-19 is still a matter of debate. RAAS represents an important protagonist in the pathogenesis of COVID-19, providing the virus with the receptor of entry into host cells and determining its organotropism. Furthermore, following infection, the virus is able to cause an increase in plasma ACE2 activity, compromising the normal function of the RAAS. This dysfunction could contribute to the establishment of the thrombo-inflammatory state characteristic of severe forms of COVID-19. Drugs targeting RAAS represent promising therapeutic options for COVID-19 sufferers.
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title_short	Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019
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Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019

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