Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties

Dragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and...
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Autor*in:	Paweł Paśko [verfasserIn] Agnieszka Galanty [verfasserIn] Paweł Zagrodzki [verfasserIn] Patraporn Luksirikul [verfasserIn] Dinorah Barasch [verfasserIn] Alina Nemirovski [verfasserIn] Shela Gorinstein [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	dragon fruits cytotoxicity interaction with drug carrier antioxidant activity anti-inflammatory activity

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 26(2021), 8, p 2158
Übergeordnetes Werk:	volume:26 ; year:2021 ; number:8, p 2158

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules26082158

Katalog-ID:	DOAJ053820444

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callnumber-first	Q - Science
author	Paweł Paśko
spellingShingle	Paweł Paśko misc QD241-441 misc dragon fruits misc cytotoxicity misc interaction with drug carrier misc antioxidant activity misc anti-inflammatory activity misc Organic chemistry Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties
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topic_title	QD241-441 Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties dragon fruits cytotoxicity interaction with drug carrier antioxidant activity anti-inflammatory activity
topic	misc QD241-441 misc dragon fruits misc cytotoxicity misc interaction with drug carrier misc antioxidant activity misc anti-inflammatory activity misc Organic chemistry
topic_unstemmed	misc QD241-441 misc dragon fruits misc cytotoxicity misc interaction with drug carrier misc antioxidant activity misc anti-inflammatory activity misc Organic chemistry
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title	Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties
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title_full	Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties
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author_browse	Paweł Paśko Agnieszka Galanty Paweł Zagrodzki Patraporn Luksirikul Dinorah Barasch Alina Nemirovski Shela Gorinstein
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title_sort	dragon fruits as a reservoir of natural polyphenolics with chemopreventive properties
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title_auth	Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties
abstract	Dragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and methanol extracts and antioxidant activity was investigated. Moreover, cytotoxic activity against cancer and normal cells of skin, prostate, and gastrointestinal origin was performed, accompanied by anti-inflammatory assay based on NO production in RAW 264.7 macrophage model. Additionally, the quenching properties of polyphenols from fruits were determined by the interaction of the main drug carrier in blood human serum (HSA). The chemometric analysis was used to reveal the relationships between the determined parameters. Dragon fruits harvested in Israel revealed higher antioxidant properties and total content of polyphenols and betacyanins when compared to those from Thailand. The examined fruits of both origins showed significant cytotoxic activity toward colon and prostate cancer cells, with no toxic effect on normal cells, but also no anti-inflammatory effect. Moreover, a high binding ability to HSA was observed for water extracts of dragon fruits. All these predestine dragon fruits are the candidates for the attractive and chemopreventive elements of daily diet.
abstractGer	Dragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and methanol extracts and antioxidant activity was investigated. Moreover, cytotoxic activity against cancer and normal cells of skin, prostate, and gastrointestinal origin was performed, accompanied by anti-inflammatory assay based on NO production in RAW 264.7 macrophage model. Additionally, the quenching properties of polyphenols from fruits were determined by the interaction of the main drug carrier in blood human serum (HSA). The chemometric analysis was used to reveal the relationships between the determined parameters. Dragon fruits harvested in Israel revealed higher antioxidant properties and total content of polyphenols and betacyanins when compared to those from Thailand. The examined fruits of both origins showed significant cytotoxic activity toward colon and prostate cancer cells, with no toxic effect on normal cells, but also no anti-inflammatory effect. Moreover, a high binding ability to HSA was observed for water extracts of dragon fruits. All these predestine dragon fruits are the candidates for the attractive and chemopreventive elements of daily diet.
abstract_unstemmed	Dragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and methanol extracts and antioxidant activity was investigated. Moreover, cytotoxic activity against cancer and normal cells of skin, prostate, and gastrointestinal origin was performed, accompanied by anti-inflammatory assay based on NO production in RAW 264.7 macrophage model. Additionally, the quenching properties of polyphenols from fruits were determined by the interaction of the main drug carrier in blood human serum (HSA). The chemometric analysis was used to reveal the relationships between the determined parameters. Dragon fruits harvested in Israel revealed higher antioxidant properties and total content of polyphenols and betacyanins when compared to those from Thailand. The examined fruits of both origins showed significant cytotoxic activity toward colon and prostate cancer cells, with no toxic effect on normal cells, but also no anti-inflammatory effect. Moreover, a high binding ability to HSA was observed for water extracts of dragon fruits. All these predestine dragon fruits are the candidates for the attractive and chemopreventive elements of daily diet.
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title_short	Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties
url	https://doi.org/10.3390/molecules26082158 https://doaj.org/article/50e6b6a6d60143e388de7a9d1a5bd04d https://www.mdpi.com/1420-3049/26/8/2158 https://doaj.org/toc/1420-3049
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up_date	2024-07-03T19:44:29.219Z
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Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties

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