Neudesin is involved in anxiety behavior: structural and neurochemical correlates

Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions) of neudesin-null mic...
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Autor*in:	Ashley eNovais [verfasserIn] Ana Catarina Ferreira [verfasserIn] Fernanda eMarques [verfasserIn] José M Pêgo [verfasserIn] João J Cerqueira [verfasserIn] Ana eDavid-Pereira [verfasserIn] Filipa L Campos [verfasserIn] Christina eDalla [verfasserIn] Nikolaos eKokras [verfasserIn] Nuno eSousa [verfasserIn] Joana A Palha [verfasserIn] Joao C Sousa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Anxiety Dopamine ventral hippocampus neudesin bed nucleus of the stria terminalis.

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 7(2013)
Übergeordnetes Werk:	volume:7 ; year:2013

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2013.00119

Katalog-ID:	DOAJ053849639

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author	Ashley eNovais
spellingShingle	Ashley eNovais misc RC321-571 misc Anxiety misc Dopamine misc ventral hippocampus misc neudesin misc bed nucleus of the stria terminalis. misc Neurosciences. Biological psychiatry. Neuropsychiatry Neudesin is involved in anxiety behavior: structural and neurochemical correlates
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topic_title	RC321-571 Neudesin is involved in anxiety behavior: structural and neurochemical correlates Anxiety Dopamine ventral hippocampus neudesin bed nucleus of the stria terminalis
topic	misc RC321-571 misc Anxiety misc Dopamine misc ventral hippocampus misc neudesin misc bed nucleus of the stria terminalis. misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Anxiety misc Dopamine misc ventral hippocampus misc neudesin misc bed nucleus of the stria terminalis. misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Neudesin is involved in anxiety behavior: structural and neurochemical correlates
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title_full	Neudesin is involved in anxiety behavior: structural and neurochemical correlates
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title_sort	neudesin is involved in anxiety behavior: structural and neurochemical correlates
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title_auth	Neudesin is involved in anxiety behavior: structural and neurochemical correlates
abstract	Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze, light/dark box and novelty suppressed feeding tests, but not in the acoustic startle test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.
abstractGer	Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze, light/dark box and novelty suppressed feeding tests, but not in the acoustic startle test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.
abstract_unstemmed	Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze, light/dark box and novelty suppressed feeding tests, but not in the acoustic startle test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.
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title_short	Neudesin is involved in anxiety behavior: structural and neurochemical correlates
url	https://doi.org/10.3389/fnbeh.2013.00119 https://doaj.org/article/0002fe366a034b37a397e32592327ec6 http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00119/full https://doaj.org/toc/1662-5153
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author2	Ashley eNovais Ana Catarina Ferreira Fernanda eMarques José M Pêgo João J Cerqueira Ana eDavid-Pereira Filipa L Campos Christina eDalla Nikolaos eKokras Nuno eSousa Joana A Palha Joao C Sousa
author2Str	Ashley eNovais Ana Catarina Ferreira Fernanda eMarques José M Pêgo João J Cerqueira Ana eDavid-Pereira Filipa L Campos Christina eDalla Nikolaos eKokras Nuno eSousa Joana A Palha Joao C Sousa
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up_date	2024-07-03T19:54:21.720Z
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In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze, light/dark box and novelty suppressed feeding tests, but not in the acoustic startle test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. 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Neudesin is involved in anxiety behavior: structural and neurochemical correlates

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