The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial.
Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this...
Ausführliche Beschreibung
Autor*in: |
Valentina Ciappolino [verfasserIn] Giuseppe DelVecchio [verfasserIn] Cecilia Prunas [verfasserIn] Angela Andreella [verfasserIn] Livio Finos [verfasserIn] Elisabetta Caletti [verfasserIn] Francesca Siri [verfasserIn] Alessandra Mazzocchi [verfasserIn] Andrea Botturi [verfasserIn] Stefano Turolo [verfasserIn] Carlo Agostoni [verfasserIn] Paolo Brambilla [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Nutrients - MDPI AG, 2009, 12(2020), 3, p 708 |
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Übergeordnetes Werk: |
volume:12 ; year:2020 ; number:3, p 708 |
Links: |
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DOI / URN: |
10.3390/nu12030708 |
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Katalog-ID: |
DOAJ053850742 |
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10.3390/nu12030708 doi (DE-627)DOAJ053850742 (DE-599)DOAJ43c9c0096a6b4f3da4251ef70f0d2565 DE-627 ger DE-627 rakwb eng TX341-641 Valentina Ciappolino verfasserin aut The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. bipolar disorder docosahexaenoic acid ω-3 long chain polyunsaturated fatty acids cognitive functions Nutrition. Foods and food supply Giuseppe DelVecchio verfasserin aut Cecilia Prunas verfasserin aut Angela Andreella verfasserin aut Livio Finos verfasserin aut Elisabetta Caletti verfasserin aut Francesca Siri verfasserin aut Alessandra Mazzocchi verfasserin aut Andrea Botturi verfasserin aut Stefano Turolo verfasserin aut Carlo Agostoni verfasserin aut Paolo Brambilla verfasserin aut In Nutrients MDPI AG, 2009 12(2020), 3, p 708 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:12 year:2020 number:3, p 708 https://doi.org/10.3390/nu12030708 kostenfrei https://doaj.org/article/43c9c0096a6b4f3da4251ef70f0d2565 kostenfrei https://www.mdpi.com/2072-6643/12/3/708 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 708 |
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10.3390/nu12030708 doi (DE-627)DOAJ053850742 (DE-599)DOAJ43c9c0096a6b4f3da4251ef70f0d2565 DE-627 ger DE-627 rakwb eng TX341-641 Valentina Ciappolino verfasserin aut The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. bipolar disorder docosahexaenoic acid ω-3 long chain polyunsaturated fatty acids cognitive functions Nutrition. Foods and food supply Giuseppe DelVecchio verfasserin aut Cecilia Prunas verfasserin aut Angela Andreella verfasserin aut Livio Finos verfasserin aut Elisabetta Caletti verfasserin aut Francesca Siri verfasserin aut Alessandra Mazzocchi verfasserin aut Andrea Botturi verfasserin aut Stefano Turolo verfasserin aut Carlo Agostoni verfasserin aut Paolo Brambilla verfasserin aut In Nutrients MDPI AG, 2009 12(2020), 3, p 708 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:12 year:2020 number:3, p 708 https://doi.org/10.3390/nu12030708 kostenfrei https://doaj.org/article/43c9c0096a6b4f3da4251ef70f0d2565 kostenfrei https://www.mdpi.com/2072-6643/12/3/708 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 708 |
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10.3390/nu12030708 doi (DE-627)DOAJ053850742 (DE-599)DOAJ43c9c0096a6b4f3da4251ef70f0d2565 DE-627 ger DE-627 rakwb eng TX341-641 Valentina Ciappolino verfasserin aut The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. bipolar disorder docosahexaenoic acid ω-3 long chain polyunsaturated fatty acids cognitive functions Nutrition. Foods and food supply Giuseppe DelVecchio verfasserin aut Cecilia Prunas verfasserin aut Angela Andreella verfasserin aut Livio Finos verfasserin aut Elisabetta Caletti verfasserin aut Francesca Siri verfasserin aut Alessandra Mazzocchi verfasserin aut Andrea Botturi verfasserin aut Stefano Turolo verfasserin aut Carlo Agostoni verfasserin aut Paolo Brambilla verfasserin aut In Nutrients MDPI AG, 2009 12(2020), 3, p 708 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:12 year:2020 number:3, p 708 https://doi.org/10.3390/nu12030708 kostenfrei https://doaj.org/article/43c9c0096a6b4f3da4251ef70f0d2565 kostenfrei https://www.mdpi.com/2072-6643/12/3/708 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 708 |
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10.3390/nu12030708 doi (DE-627)DOAJ053850742 (DE-599)DOAJ43c9c0096a6b4f3da4251ef70f0d2565 DE-627 ger DE-627 rakwb eng TX341-641 Valentina Ciappolino verfasserin aut The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. bipolar disorder docosahexaenoic acid ω-3 long chain polyunsaturated fatty acids cognitive functions Nutrition. Foods and food supply Giuseppe DelVecchio verfasserin aut Cecilia Prunas verfasserin aut Angela Andreella verfasserin aut Livio Finos verfasserin aut Elisabetta Caletti verfasserin aut Francesca Siri verfasserin aut Alessandra Mazzocchi verfasserin aut Andrea Botturi verfasserin aut Stefano Turolo verfasserin aut Carlo Agostoni verfasserin aut Paolo Brambilla verfasserin aut In Nutrients MDPI AG, 2009 12(2020), 3, p 708 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:12 year:2020 number:3, p 708 https://doi.org/10.3390/nu12030708 kostenfrei https://doaj.org/article/43c9c0096a6b4f3da4251ef70f0d2565 kostenfrei https://www.mdpi.com/2072-6643/12/3/708 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 708 |
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10.3390/nu12030708 doi (DE-627)DOAJ053850742 (DE-599)DOAJ43c9c0096a6b4f3da4251ef70f0d2565 DE-627 ger DE-627 rakwb eng TX341-641 Valentina Ciappolino verfasserin aut The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. bipolar disorder docosahexaenoic acid ω-3 long chain polyunsaturated fatty acids cognitive functions Nutrition. Foods and food supply Giuseppe DelVecchio verfasserin aut Cecilia Prunas verfasserin aut Angela Andreella verfasserin aut Livio Finos verfasserin aut Elisabetta Caletti verfasserin aut Francesca Siri verfasserin aut Alessandra Mazzocchi verfasserin aut Andrea Botturi verfasserin aut Stefano Turolo verfasserin aut Carlo Agostoni verfasserin aut Paolo Brambilla verfasserin aut In Nutrients MDPI AG, 2009 12(2020), 3, p 708 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:12 year:2020 number:3, p 708 https://doi.org/10.3390/nu12030708 kostenfrei https://doaj.org/article/43c9c0096a6b4f3da4251ef70f0d2565 kostenfrei https://www.mdpi.com/2072-6643/12/3/708 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 708 |
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The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. |
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Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. |
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Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. |
abstract_unstemmed |
Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. |
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Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i<z</i< = 3.9, <i<p</i< = 0.003) or BD with placebo (<i<t </i<= 3.7, <i<p</i< = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bipolar disorder</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">docosahexaenoic acid</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ω-3 long chain polyunsaturated fatty acids</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cognitive functions</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Nutrition. 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