Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts

Soft tissue sealing around implants acts as a barrier between the alveolar bone and oral environment, protecting implants from the invasion of bacteria or external stimuli. In this work, magnesium (Mg) and zinc (Zn) are introduced into titanium by plasma immersed ion implantation technology, and the...
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Autor*in:	Lanyu Wang [verfasserIn] Qiming Luo [verfasserIn] Xianming Zhang [verfasserIn] Jiajun Qiu [verfasserIn] Shi Qian [verfasserIn] Xuanyong Liu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Human gingival fibroblasts Soft tissue sealing Magnesium Zinc Plasma immersion ion implantation

Übergeordnetes Werk:	In: Bioactive Materials - KeAi Communications Co., Ltd., 2017, 6(2021), 1, Seite 64-74
Übergeordnetes Werk:	volume:6 ; year:2021 ; number:1 ; pages:64-74

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.bioactmat.2020.07.012

Katalog-ID:	DOAJ053911547

Internformat


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authorswithroles_txt_mv	Lanyu Wang @@aut@@ Qiming Luo @@aut@@ Xianming Zhang @@aut@@ Jiajun Qiu @@aut@@ Shi Qian @@aut@@ Xuanyong Liu @@aut@@
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callnumber-first	T - Technology
author	Lanyu Wang
spellingShingle	Lanyu Wang misc TA401-492 misc QH301-705.5 misc Human gingival fibroblasts misc Soft tissue sealing misc Magnesium misc Zinc misc Plasma immersion ion implantation misc Materials of engineering and construction. Mechanics of materials misc Biology (General) Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts
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topic_title	TA401-492 QH301-705.5 Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts Human gingival fibroblasts Soft tissue sealing Magnesium Zinc Plasma immersion ion implantation
topic	misc TA401-492 misc QH301-705.5 misc Human gingival fibroblasts misc Soft tissue sealing misc Magnesium misc Zinc misc Plasma immersion ion implantation misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
topic_unstemmed	misc TA401-492 misc QH301-705.5 misc Human gingival fibroblasts misc Soft tissue sealing misc Magnesium misc Zinc misc Plasma immersion ion implantation misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
topic_browse	misc TA401-492 misc QH301-705.5 misc Human gingival fibroblasts misc Soft tissue sealing misc Magnesium misc Zinc misc Plasma immersion ion implantation misc Materials of engineering and construction. Mechanics of materials misc Biology (General)
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title	Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts
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title_full	Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts
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title_sort	co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts
callnumber	TA401-492
title_auth	Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts
abstract	Soft tissue sealing around implants acts as a barrier between the alveolar bone and oral environment, protecting implants from the invasion of bacteria or external stimuli. In this work, magnesium (Mg) and zinc (Zn) are introduced into titanium by plasma immersed ion implantation technology, and their effects on the behaviors of human gingival fibroblasts (HGFs) as well as the underlying mechanisms are investigated. Surface characterization confirms Mg and Zn exist on the surface in metallic and oxidized states. Contact angle test suggests that surface wettability of titanium changes after ion implantation and thus influences protein adsorption of surfaces. In vitro studies disclose that HGFs on Mg ion-implanted samples exhibit better adhesion and migration while cells on Zn ion-implanted samples have higher proliferation rate and amounts. The results of immunofluorescence staining and real-time reverse-transcriptase polymerase chain reaction (RT-PCR) suggest that Mg mainly regulates the motility and adhesion of HGFs through activating the MAPK signal pathway whereas Zn influences HGFs proliferation by triggering the TGF-β signal pathway. The synergistic effect of Mg and Zn ions ensure that HGFs cultured on co-implanted samples possessed both high proliferation rate and motility, which are critical to soft tissue sealing of implants.
abstractGer	Soft tissue sealing around implants acts as a barrier between the alveolar bone and oral environment, protecting implants from the invasion of bacteria or external stimuli. In this work, magnesium (Mg) and zinc (Zn) are introduced into titanium by plasma immersed ion implantation technology, and their effects on the behaviors of human gingival fibroblasts (HGFs) as well as the underlying mechanisms are investigated. Surface characterization confirms Mg and Zn exist on the surface in metallic and oxidized states. Contact angle test suggests that surface wettability of titanium changes after ion implantation and thus influences protein adsorption of surfaces. In vitro studies disclose that HGFs on Mg ion-implanted samples exhibit better adhesion and migration while cells on Zn ion-implanted samples have higher proliferation rate and amounts. The results of immunofluorescence staining and real-time reverse-transcriptase polymerase chain reaction (RT-PCR) suggest that Mg mainly regulates the motility and adhesion of HGFs through activating the MAPK signal pathway whereas Zn influences HGFs proliferation by triggering the TGF-β signal pathway. The synergistic effect of Mg and Zn ions ensure that HGFs cultured on co-implanted samples possessed both high proliferation rate and motility, which are critical to soft tissue sealing of implants.
abstract_unstemmed	Soft tissue sealing around implants acts as a barrier between the alveolar bone and oral environment, protecting implants from the invasion of bacteria or external stimuli. In this work, magnesium (Mg) and zinc (Zn) are introduced into titanium by plasma immersed ion implantation technology, and their effects on the behaviors of human gingival fibroblasts (HGFs) as well as the underlying mechanisms are investigated. Surface characterization confirms Mg and Zn exist on the surface in metallic and oxidized states. Contact angle test suggests that surface wettability of titanium changes after ion implantation and thus influences protein adsorption of surfaces. In vitro studies disclose that HGFs on Mg ion-implanted samples exhibit better adhesion and migration while cells on Zn ion-implanted samples have higher proliferation rate and amounts. The results of immunofluorescence staining and real-time reverse-transcriptase polymerase chain reaction (RT-PCR) suggest that Mg mainly regulates the motility and adhesion of HGFs through activating the MAPK signal pathway whereas Zn influences HGFs proliferation by triggering the TGF-β signal pathway. The synergistic effect of Mg and Zn ions ensure that HGFs cultured on co-implanted samples possessed both high proliferation rate and motility, which are critical to soft tissue sealing of implants.
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title_short	Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts
url	https://doi.org/10.1016/j.bioactmat.2020.07.012 https://doaj.org/article/c388c572590649bda641fb283f2656fc http://www.sciencedirect.com/science/article/pii/S2452199X20301390 https://doaj.org/toc/2452-199X
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author2	Qiming Luo Xianming Zhang Jiajun Qiu Shi Qian Xuanyong Liu
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doi_str	10.1016/j.bioactmat.2020.07.012
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up_date	2024-07-03T20:15:39.303Z
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