The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring
Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affect...
Ausführliche Beschreibung
Autor*in: |
Gerard Wong [verfasserIn] Jacquelyn M. Weir [verfasserIn] Priti Mishra [verfasserIn] Kevin Huynh [verfasserIn] Brunda Nijagal [verfasserIn] Varsha Gupta [verfasserIn] Birit F. P. Broekman [verfasserIn] Mary Foong-Fong Chong [verfasserIn] Shiao-Yng Chan [verfasserIn] Kok Hian Tan [verfasserIn] Dedreia Tull [verfasserIn] Malcolm McConville [verfasserIn] Philip C. Calder [verfasserIn] Keith M. Godfrey [verfasserIn] Yap Seng Chong [verfasserIn] Peter D. Gluckman [verfasserIn] Michael J. Meaney [verfasserIn] Peter J. Meikle [verfasserIn] Neerja Karnani [verfasserIn] |
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E-Artikel |
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Englisch |
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2021 |
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Übergeordnetes Werk: |
In: Translational Psychiatry - Nature Publishing Group, 2012, 11(2021), 1, Seite 11 |
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Übergeordnetes Werk: |
volume:11 ; year:2021 ; number:1 ; pages:11 |
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DOI / URN: |
10.1038/s41398-021-01208-x |
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Katalog-ID: |
DOAJ053949307 |
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520 | |a Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. | ||
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10.1038/s41398-021-01208-x doi (DE-627)DOAJ053949307 (DE-599)DOAJ4e43c860447e409ab62884e81a67aa02 DE-627 ger DE-627 rakwb eng RC321-571 Gerard Wong verfasserin aut The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. Neurosciences. Biological psychiatry. Neuropsychiatry Jacquelyn M. Weir verfasserin aut Priti Mishra verfasserin aut Kevin Huynh verfasserin aut Brunda Nijagal verfasserin aut Varsha Gupta verfasserin aut Birit F. P. Broekman verfasserin aut Mary Foong-Fong Chong verfasserin aut Shiao-Yng Chan verfasserin aut Kok Hian Tan verfasserin aut Dedreia Tull verfasserin aut Malcolm McConville verfasserin aut Philip C. Calder verfasserin aut Keith M. Godfrey verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Michael J. Meaney verfasserin aut Peter J. Meikle verfasserin aut Neerja Karnani verfasserin aut In Translational Psychiatry Nature Publishing Group, 2012 11(2021), 1, Seite 11 (DE-627)660807378 (DE-600)2609311-X 21583188 nnns volume:11 year:2021 number:1 pages:11 https://doi.org/10.1038/s41398-021-01208-x kostenfrei https://doaj.org/article/4e43c860447e409ab62884e81a67aa02 kostenfrei https://doi.org/10.1038/s41398-021-01208-x kostenfrei https://doaj.org/toc/2158-3188 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 11 |
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10.1038/s41398-021-01208-x doi (DE-627)DOAJ053949307 (DE-599)DOAJ4e43c860447e409ab62884e81a67aa02 DE-627 ger DE-627 rakwb eng RC321-571 Gerard Wong verfasserin aut The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. Neurosciences. Biological psychiatry. Neuropsychiatry Jacquelyn M. Weir verfasserin aut Priti Mishra verfasserin aut Kevin Huynh verfasserin aut Brunda Nijagal verfasserin aut Varsha Gupta verfasserin aut Birit F. P. Broekman verfasserin aut Mary Foong-Fong Chong verfasserin aut Shiao-Yng Chan verfasserin aut Kok Hian Tan verfasserin aut Dedreia Tull verfasserin aut Malcolm McConville verfasserin aut Philip C. Calder verfasserin aut Keith M. Godfrey verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Michael J. Meaney verfasserin aut Peter J. Meikle verfasserin aut Neerja Karnani verfasserin aut In Translational Psychiatry Nature Publishing Group, 2012 11(2021), 1, Seite 11 (DE-627)660807378 (DE-600)2609311-X 21583188 nnns volume:11 year:2021 number:1 pages:11 https://doi.org/10.1038/s41398-021-01208-x kostenfrei https://doaj.org/article/4e43c860447e409ab62884e81a67aa02 kostenfrei https://doi.org/10.1038/s41398-021-01208-x kostenfrei https://doaj.org/toc/2158-3188 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 11 |
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10.1038/s41398-021-01208-x doi (DE-627)DOAJ053949307 (DE-599)DOAJ4e43c860447e409ab62884e81a67aa02 DE-627 ger DE-627 rakwb eng RC321-571 Gerard Wong verfasserin aut The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. Neurosciences. Biological psychiatry. Neuropsychiatry Jacquelyn M. Weir verfasserin aut Priti Mishra verfasserin aut Kevin Huynh verfasserin aut Brunda Nijagal verfasserin aut Varsha Gupta verfasserin aut Birit F. P. Broekman verfasserin aut Mary Foong-Fong Chong verfasserin aut Shiao-Yng Chan verfasserin aut Kok Hian Tan verfasserin aut Dedreia Tull verfasserin aut Malcolm McConville verfasserin aut Philip C. Calder verfasserin aut Keith M. Godfrey verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Michael J. Meaney verfasserin aut Peter J. Meikle verfasserin aut Neerja Karnani verfasserin aut In Translational Psychiatry Nature Publishing Group, 2012 11(2021), 1, Seite 11 (DE-627)660807378 (DE-600)2609311-X 21583188 nnns volume:11 year:2021 number:1 pages:11 https://doi.org/10.1038/s41398-021-01208-x kostenfrei https://doaj.org/article/4e43c860447e409ab62884e81a67aa02 kostenfrei https://doi.org/10.1038/s41398-021-01208-x kostenfrei https://doaj.org/toc/2158-3188 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 11 |
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placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
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The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
abstract |
Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. |
abstractGer |
Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. |
abstract_unstemmed |
Abstract While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. |
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The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
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Jacquelyn M. Weir Priti Mishra Kevin Huynh Brunda Nijagal Varsha Gupta Birit F. P. Broekman Mary Foong-Fong Chong Shiao-Yng Chan Kok Hian Tan Dedreia Tull Malcolm McConville Philip C. Calder Keith M. Godfrey Yap Seng Chong Peter D. Gluckman Michael J. Meaney Peter J. Meikle Neerja Karnani |
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Jacquelyn M. Weir Priti Mishra Kevin Huynh Brunda Nijagal Varsha Gupta Birit F. P. Broekman Mary Foong-Fong Chong Shiao-Yng Chan Kok Hian Tan Dedreia Tull Malcolm McConville Philip C. Calder Keith M. Godfrey Yap Seng Chong Peter D. Gluckman Michael J. Meaney Peter J. Meikle Neerja Karnani |
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