eIF2B-capturing viral protein NSs suppresses the integrated stress response

Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates neurite degradation under stress.

Gespeichert in:

Autor*in:	Kazuhiro Kashiwagi [verfasserIn] Yuichi Shichino [verfasserIn] Tatsuya Osaki [verfasserIn] Ayako Sakamoto [verfasserIn] Madoka Nishimoto [verfasserIn] Mari Takahashi [verfasserIn] Mari Mito [verfasserIn] Friedemann Weber [verfasserIn] Yoshiho Ikeuchi [verfasserIn] Shintaro Iwasaki [verfasserIn] Takuhiro Ito [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 12
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-021-27337-x

Katalog-ID:	DOAJ053972848

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author	Kazuhiro Kashiwagi
spellingShingle	Kazuhiro Kashiwagi misc Science misc Q eIF2B-capturing viral protein NSs suppresses the integrated stress response
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topic_title	eIF2B-capturing viral protein NSs suppresses the integrated stress response
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title	eIF2B-capturing viral protein NSs suppresses the integrated stress response
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title_sort	eif2b-capturing viral protein nss suppresses the integrated stress response
title_auth	eIF2B-capturing viral protein NSs suppresses the integrated stress response
abstract	Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates neurite degradation under stress.
abstractGer	Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates neurite degradation under stress.
abstract_unstemmed	Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates neurite degradation under stress.
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title_short	eIF2B-capturing viral protein NSs suppresses the integrated stress response
url	https://doi.org/10.1038/s41467-021-27337-x https://doaj.org/article/e841f121eeb6451da9f14256c533b642 https://doaj.org/toc/2041-1723
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