Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)

Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Itali...
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Autor*in:	Martina Bonifazi [verfasserIn] Federico Mei [verfasserIn] Edlira Skrami [verfasserIn] Lara Letizia Latini [verfasserIn] Donatella Amico [verfasserIn] Elisabetta Balestro [verfasserIn] Francesco Bini [verfasserIn] Floriano Bonifazi [verfasserIn] Antonella Caminati [verfasserIn] Piero Candoli [verfasserIn] Saverio Cinti [verfasserIn] Susanna Contucci [verfasserIn] Alessandro Di Marco Berardino [verfasserIn] Sergio Harari [verfasserIn] Guido Levi [verfasserIn] Sara Lococo [verfasserIn] Vincenzo Menditto [verfasserIn] Giampietro Marchetti [verfasserIn] Sara Piciucchi [verfasserIn] Venerino Poletti [verfasserIn] Claudia Ravaglia [verfasserIn] Marina Saetta [verfasserIn] Gianluca Svegliati-Baroni [verfasserIn] Sara Tomassetti [verfasserIn] Mario Tamburrini [verfasserIn] Alessandro Zanforlin [verfasserIn] Umberto Zuccon [verfasserIn] Lina Zuccatosta [verfasserIn] Stefano Gasparini [verfasserIn] Flavia Carle [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	obesity asthma comorbidity mechanical ventilation pneumonia COVID-19

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 6, p 1218
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:6, p 1218

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10061218

Katalog-ID:	DOAJ054006767

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allfields	10.3390/jcm10061218 doi (DE-627)DOAJ054006767 (DE-599)DOAJdff25174db5c45d29add591d4d0c79b4 DE-627 ger DE-627 rakwb eng Martina Bonifazi verfasserin aut Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions. obesity asthma comorbidity mechanical ventilation pneumonia COVID-19 Medicine R Federico Mei verfasserin aut Edlira Skrami verfasserin aut Lara Letizia Latini verfasserin aut Donatella Amico verfasserin aut Elisabetta Balestro verfasserin aut Francesco Bini verfasserin aut Floriano Bonifazi verfasserin aut Antonella Caminati verfasserin aut Piero Candoli verfasserin aut Saverio Cinti verfasserin aut Susanna Contucci verfasserin aut Alessandro Di Marco Berardino verfasserin aut Sergio Harari verfasserin aut Guido Levi verfasserin aut Sara Lococo verfasserin aut Vincenzo Menditto verfasserin aut Giampietro Marchetti verfasserin aut Sara Piciucchi verfasserin aut Venerino Poletti verfasserin aut Claudia Ravaglia verfasserin aut Marina Saetta verfasserin aut Gianluca Svegliati-Baroni verfasserin aut Sara Tomassetti verfasserin aut Mario Tamburrini verfasserin aut Alessandro Zanforlin verfasserin aut Umberto Zuccon verfasserin aut Lina Zuccatosta verfasserin aut Stefano Gasparini verfasserin aut Flavia Carle verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 6, p 1218 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:6, p 1218 https://doi.org/10.3390/jcm10061218 kostenfrei https://doaj.org/article/dff25174db5c45d29add591d4d0c79b4 kostenfrei https://www.mdpi.com/2077-0383/10/6/1218 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 6, p 1218
spelling	10.3390/jcm10061218 doi (DE-627)DOAJ054006767 (DE-599)DOAJdff25174db5c45d29add591d4d0c79b4 DE-627 ger DE-627 rakwb eng Martina Bonifazi verfasserin aut Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions. obesity asthma comorbidity mechanical ventilation pneumonia COVID-19 Medicine R Federico Mei verfasserin aut Edlira Skrami verfasserin aut Lara Letizia Latini verfasserin aut Donatella Amico verfasserin aut Elisabetta Balestro verfasserin aut Francesco Bini verfasserin aut Floriano Bonifazi verfasserin aut Antonella Caminati verfasserin aut Piero Candoli verfasserin aut Saverio Cinti verfasserin aut Susanna Contucci verfasserin aut Alessandro Di Marco Berardino verfasserin aut Sergio Harari verfasserin aut Guido Levi verfasserin aut Sara Lococo verfasserin aut Vincenzo Menditto verfasserin aut Giampietro Marchetti verfasserin aut Sara Piciucchi verfasserin aut Venerino Poletti verfasserin aut Claudia Ravaglia verfasserin aut Marina Saetta verfasserin aut Gianluca Svegliati-Baroni verfasserin aut Sara Tomassetti verfasserin aut Mario Tamburrini verfasserin aut Alessandro Zanforlin verfasserin aut Umberto Zuccon verfasserin aut Lina Zuccatosta verfasserin aut Stefano Gasparini verfasserin aut Flavia Carle verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 6, p 1218 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:6, p 1218 https://doi.org/10.3390/jcm10061218 kostenfrei https://doaj.org/article/dff25174db5c45d29add591d4d0c79b4 kostenfrei https://www.mdpi.com/2077-0383/10/6/1218 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 6, p 1218
allfields_unstemmed	10.3390/jcm10061218 doi (DE-627)DOAJ054006767 (DE-599)DOAJdff25174db5c45d29add591d4d0c79b4 DE-627 ger DE-627 rakwb eng Martina Bonifazi verfasserin aut Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions. obesity asthma comorbidity mechanical ventilation pneumonia COVID-19 Medicine R Federico Mei verfasserin aut Edlira Skrami verfasserin aut Lara Letizia Latini verfasserin aut Donatella Amico verfasserin aut Elisabetta Balestro verfasserin aut Francesco Bini verfasserin aut Floriano Bonifazi verfasserin aut Antonella Caminati verfasserin aut Piero Candoli verfasserin aut Saverio Cinti verfasserin aut Susanna Contucci verfasserin aut Alessandro Di Marco Berardino verfasserin aut Sergio Harari verfasserin aut Guido Levi verfasserin aut Sara Lococo verfasserin aut Vincenzo Menditto verfasserin aut Giampietro Marchetti verfasserin aut Sara Piciucchi verfasserin aut Venerino Poletti verfasserin aut Claudia Ravaglia verfasserin aut Marina Saetta verfasserin aut Gianluca Svegliati-Baroni verfasserin aut Sara Tomassetti verfasserin aut Mario Tamburrini verfasserin aut Alessandro Zanforlin verfasserin aut Umberto Zuccon verfasserin aut Lina Zuccatosta verfasserin aut Stefano Gasparini verfasserin aut Flavia Carle verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 6, p 1218 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:6, p 1218 https://doi.org/10.3390/jcm10061218 kostenfrei https://doaj.org/article/dff25174db5c45d29add591d4d0c79b4 kostenfrei https://www.mdpi.com/2077-0383/10/6/1218 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 6, p 1218
allfieldsGer	10.3390/jcm10061218 doi (DE-627)DOAJ054006767 (DE-599)DOAJdff25174db5c45d29add591d4d0c79b4 DE-627 ger DE-627 rakwb eng Martina Bonifazi verfasserin aut Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions. obesity asthma comorbidity mechanical ventilation pneumonia COVID-19 Medicine R Federico Mei verfasserin aut Edlira Skrami verfasserin aut Lara Letizia Latini verfasserin aut Donatella Amico verfasserin aut Elisabetta Balestro verfasserin aut Francesco Bini verfasserin aut Floriano Bonifazi verfasserin aut Antonella Caminati verfasserin aut Piero Candoli verfasserin aut Saverio Cinti verfasserin aut Susanna Contucci verfasserin aut Alessandro Di Marco Berardino verfasserin aut Sergio Harari verfasserin aut Guido Levi verfasserin aut Sara Lococo verfasserin aut Vincenzo Menditto verfasserin aut Giampietro Marchetti verfasserin aut Sara Piciucchi verfasserin aut Venerino Poletti verfasserin aut Claudia Ravaglia verfasserin aut Marina Saetta verfasserin aut Gianluca Svegliati-Baroni verfasserin aut Sara Tomassetti verfasserin aut Mario Tamburrini verfasserin aut Alessandro Zanforlin verfasserin aut Umberto Zuccon verfasserin aut Lina Zuccatosta verfasserin aut Stefano Gasparini verfasserin aut Flavia Carle verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 6, p 1218 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:6, p 1218 https://doi.org/10.3390/jcm10061218 kostenfrei https://doaj.org/article/dff25174db5c45d29add591d4d0c79b4 kostenfrei https://www.mdpi.com/2077-0383/10/6/1218 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 6, p 1218
allfieldsSound	10.3390/jcm10061218 doi (DE-627)DOAJ054006767 (DE-599)DOAJdff25174db5c45d29add591d4d0c79b4 DE-627 ger DE-627 rakwb eng Martina Bonifazi verfasserin aut Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions. obesity asthma comorbidity mechanical ventilation pneumonia COVID-19 Medicine R Federico Mei verfasserin aut Edlira Skrami verfasserin aut Lara Letizia Latini verfasserin aut Donatella Amico verfasserin aut Elisabetta Balestro verfasserin aut Francesco Bini verfasserin aut Floriano Bonifazi verfasserin aut Antonella Caminati verfasserin aut Piero Candoli verfasserin aut Saverio Cinti verfasserin aut Susanna Contucci verfasserin aut Alessandro Di Marco Berardino verfasserin aut Sergio Harari verfasserin aut Guido Levi verfasserin aut Sara Lococo verfasserin aut Vincenzo Menditto verfasserin aut Giampietro Marchetti verfasserin aut Sara Piciucchi verfasserin aut Venerino Poletti verfasserin aut Claudia Ravaglia verfasserin aut Marina Saetta verfasserin aut Gianluca Svegliati-Baroni verfasserin aut Sara Tomassetti verfasserin aut Mario Tamburrini verfasserin aut Alessandro Zanforlin verfasserin aut Umberto Zuccon verfasserin aut Lina Zuccatosta verfasserin aut Stefano Gasparini verfasserin aut Flavia Carle verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 6, p 1218 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:6, p 1218 https://doi.org/10.3390/jcm10061218 kostenfrei https://doaj.org/article/dff25174db5c45d29add591d4d0c79b4 kostenfrei https://www.mdpi.com/2077-0383/10/6/1218 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 6, p 1218
language	English
source	In Journal of Clinical Medicine 10(2021), 6, p 1218 volume:10 year:2021 number:6, p 1218
sourceStr	In Journal of Clinical Medicine 10(2021), 6, p 1218 volume:10 year:2021 number:6, p 1218
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	obesity asthma comorbidity mechanical ventilation pneumonia COVID-19 Medicine R
isfreeaccess_bool	true
container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Martina Bonifazi @@aut@@ Federico Mei @@aut@@ Edlira Skrami @@aut@@ Lara Letizia Latini @@aut@@ Donatella Amico @@aut@@ Elisabetta Balestro @@aut@@ Francesco Bini @@aut@@ Floriano Bonifazi @@aut@@ Antonella Caminati @@aut@@ Piero Candoli @@aut@@ Saverio Cinti @@aut@@ Susanna Contucci @@aut@@ Alessandro Di Marco Berardino @@aut@@ Sergio Harari @@aut@@ Guido Levi @@aut@@ Sara Lococo @@aut@@ Vincenzo Menditto @@aut@@ Giampietro Marchetti @@aut@@ Sara Piciucchi @@aut@@ Venerino Poletti @@aut@@ Claudia Ravaglia @@aut@@ Marina Saetta @@aut@@ Gianluca Svegliati-Baroni @@aut@@ Sara Tomassetti @@aut@@ Mario Tamburrini @@aut@@ Alessandro Zanforlin @@aut@@ Umberto Zuccon @@aut@@ Lina Zuccatosta @@aut@@ Stefano Gasparini @@aut@@ Flavia Carle @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	718632478
id	DOAJ054006767
language_de	englisch
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author	Martina Bonifazi
spellingShingle	Martina Bonifazi misc obesity misc asthma misc comorbidity misc mechanical ventilation misc pneumonia misc COVID-19 misc Medicine misc R Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)
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topic_title	Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) obesity asthma comorbidity mechanical ventilation pneumonia COVID-19
topic	misc obesity misc asthma misc comorbidity misc mechanical ventilation misc pneumonia misc COVID-19 misc Medicine misc R
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title	Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)
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title_sort	predictors of worse prognosis in young and middle-aged adults hospitalized with covid-19 pneumonia: a multi-center italian study (covid-under50)
title_auth	Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)
abstract	Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.
abstractGer	Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.
abstract_unstemmed	Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present Italian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.
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title_short	Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)
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