The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization

One of the most studied metabolic routes is the biosynthesis of histidine, especially in enterobacteria where a single compact operon composed of eight adjacent genes encodes the complete set of biosynthetic enzymes. It is still not clear how <i<his</i< genes were organized in the genome...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sara Del Duca [verfasserIn] Christopher Riccardi [verfasserIn] Alberto Vassallo [verfasserIn] Giulia Fontana [verfasserIn] Lara Mitia Castronovo [verfasserIn] Sofia Chioccioli [verfasserIn] Renato Fani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	gene duplication gene fusion operon origin operon evolution regulons

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 9(2021), 7, p 1439
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:7, p 1439

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms9071439

Katalog-ID:	DOAJ054027969

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callnumber-first	Q - Science
author	Sara Del Duca
spellingShingle	Sara Del Duca misc QH301-705.5 misc gene duplication misc gene fusion misc operon origin misc operon evolution misc regulons misc Biology (General) The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization
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topic_title	QH301-705.5 The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization gene duplication gene fusion operon origin operon evolution regulons
topic	misc QH301-705.5 misc gene duplication misc gene fusion misc operon origin misc operon evolution misc regulons misc Biology (General)
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title	The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization
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title_full	The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization
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author_browse	Sara Del Duca Christopher Riccardi Alberto Vassallo Giulia Fontana Lara Mitia Castronovo Sofia Chioccioli Renato Fani
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title_sort	histidine biosynthetic genes in the superphylum bacteroidota-rhodothermota-balneolota-chlorobiota: insights into the evolution of gene structure and organization
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title_auth	The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization
abstract	One of the most studied metabolic routes is the biosynthesis of histidine, especially in enterobacteria where a single compact operon composed of eight adjacent genes encodes the complete set of biosynthetic enzymes. It is still not clear how <i<his</i< genes were organized in the genome of the last universal common ancestor community. The aim of this work was to analyze the structure, organization, phylogenetic distribution, and degree of horizontal gene transfer (HGT) of <i<his</i< genes in the Bacteroidota-Rhodothermota-Balneolota-Chlorobiota superphylum, a group of phylogenetically close bacteria with different surviving strategies. The analysis of the large variety of <i<his</i< gene structures and organizations revealed different scenarios with genes organized in more or less compact—heterogeneous or homogeneous—operons, in suboperons, or in regulons. The organization of <i<his</i< genes in the extant members of the superphylum suggests that in the common ancestor of this group, genes were scattered throughout the chromosome and that different forces have driven the assembly of <i<his</i< genes in compact operons. Gene fusion events and/or paralog formation, HGT of single genes or entire operons between strains of the same or different taxonomic groups, and other molecular rearrangements shaped the <i<his</i< gene structure in this superphylum.
abstractGer	One of the most studied metabolic routes is the biosynthesis of histidine, especially in enterobacteria where a single compact operon composed of eight adjacent genes encodes the complete set of biosynthetic enzymes. It is still not clear how <i<his</i< genes were organized in the genome of the last universal common ancestor community. The aim of this work was to analyze the structure, organization, phylogenetic distribution, and degree of horizontal gene transfer (HGT) of <i<his</i< genes in the Bacteroidota-Rhodothermota-Balneolota-Chlorobiota superphylum, a group of phylogenetically close bacteria with different surviving strategies. The analysis of the large variety of <i<his</i< gene structures and organizations revealed different scenarios with genes organized in more or less compact—heterogeneous or homogeneous—operons, in suboperons, or in regulons. The organization of <i<his</i< genes in the extant members of the superphylum suggests that in the common ancestor of this group, genes were scattered throughout the chromosome and that different forces have driven the assembly of <i<his</i< genes in compact operons. Gene fusion events and/or paralog formation, HGT of single genes or entire operons between strains of the same or different taxonomic groups, and other molecular rearrangements shaped the <i<his</i< gene structure in this superphylum.
abstract_unstemmed	One of the most studied metabolic routes is the biosynthesis of histidine, especially in enterobacteria where a single compact operon composed of eight adjacent genes encodes the complete set of biosynthetic enzymes. It is still not clear how <i<his</i< genes were organized in the genome of the last universal common ancestor community. The aim of this work was to analyze the structure, organization, phylogenetic distribution, and degree of horizontal gene transfer (HGT) of <i<his</i< genes in the Bacteroidota-Rhodothermota-Balneolota-Chlorobiota superphylum, a group of phylogenetically close bacteria with different surviving strategies. The analysis of the large variety of <i<his</i< gene structures and organizations revealed different scenarios with genes organized in more or less compact—heterogeneous or homogeneous—operons, in suboperons, or in regulons. The organization of <i<his</i< genes in the extant members of the superphylum suggests that in the common ancestor of this group, genes were scattered throughout the chromosome and that different forces have driven the assembly of <i<his</i< genes in compact operons. Gene fusion events and/or paralog formation, HGT of single genes or entire operons between strains of the same or different taxonomic groups, and other molecular rearrangements shaped the <i<his</i< gene structure in this superphylum.
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title_short	The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization
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author2	Christopher Riccardi Alberto Vassallo Giulia Fontana Lara Mitia Castronovo Sofia Chioccioli Renato Fani
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The Histidine Biosynthetic Genes in the Superphylum Bacteroidota-Rhodothermota-Balneolota-Chlorobiota: Insights into the Evolution of Gene Structure and Organization

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