Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates

Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research sug...
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Gespeichert in:

Autor*in:	Gregory Guthrie [verfasserIn] Douglas Burrin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	soybean oil fish oil medium chain triglycerides olive oil parenteral nutrition associated liver disease preterm infants

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 13(2021), 2, p 508
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:2, p 508

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu13020508

Katalog-ID:	DOAJ054085659

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allfieldsGer	10.3390/nu13020508 doi (DE-627)DOAJ054085659 (DE-599)DOAJ780f47af3333495e8364bc384bff21ef DE-627 ger DE-627 rakwb eng TX341-641 Gregory Guthrie verfasserin aut Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC. soybean oil fish oil medium chain triglycerides olive oil parenteral nutrition associated liver disease preterm infants Nutrition. Foods and food supply Douglas Burrin verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 2, p 508 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:2, p 508 https://doi.org/10.3390/nu13020508 kostenfrei https://doaj.org/article/780f47af3333495e8364bc384bff21ef kostenfrei https://www.mdpi.com/2072-6643/13/2/508 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 2, p 508
allfieldsSound	10.3390/nu13020508 doi (DE-627)DOAJ054085659 (DE-599)DOAJ780f47af3333495e8364bc384bff21ef DE-627 ger DE-627 rakwb eng TX341-641 Gregory Guthrie verfasserin aut Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC. soybean oil fish oil medium chain triglycerides olive oil parenteral nutrition associated liver disease preterm infants Nutrition. Foods and food supply Douglas Burrin verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 2, p 508 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:2, p 508 https://doi.org/10.3390/nu13020508 kostenfrei https://doaj.org/article/780f47af3333495e8364bc384bff21ef kostenfrei https://www.mdpi.com/2072-6643/13/2/508 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 2, p 508
language	English
source	In Nutrients 13(2021), 2, p 508 volume:13 year:2021 number:2, p 508
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topic_facet	soybean oil fish oil medium chain triglycerides olive oil parenteral nutrition associated liver disease preterm infants Nutrition. Foods and food supply
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callnumber-first	T - Technology
author	Gregory Guthrie
spellingShingle	Gregory Guthrie misc TX341-641 misc soybean oil misc fish oil misc medium chain triglycerides misc olive oil misc parenteral nutrition associated liver disease misc preterm infants misc Nutrition. Foods and food supply Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
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topic_title	TX341-641 Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates soybean oil fish oil medium chain triglycerides olive oil parenteral nutrition associated liver disease preterm infants
topic	misc TX341-641 misc soybean oil misc fish oil misc medium chain triglycerides misc olive oil misc parenteral nutrition associated liver disease misc preterm infants misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc soybean oil misc fish oil misc medium chain triglycerides misc olive oil misc parenteral nutrition associated liver disease misc preterm infants misc Nutrition. Foods and food supply
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title	Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
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title_sort	impact of parenteral lipid emulsion components on cholestatic liver disease in neonates
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title_auth	Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
abstract	Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC.
abstractGer	Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC.
abstract_unstemmed	Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC.
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title_short	Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
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