The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae

The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and a...
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Gespeichert in:

Autor*in:	Giuseppe Ercoli [verfasserIn] Elisa Ramos-Sevillano [verfasserIn] Rie Nakajima [verfasserIn] Rafael Ramiro de Assis [verfasserIn] Algis Jasinskas [verfasserIn] David Goldblatt [verfasserIn] Philip Felgner [verfasserIn] Gisbert Weckbecker [verfasserIn] Jeremy Brown [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 11(2021)
Übergeordnetes Werk:	volume:11 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2020.611661

Katalog-ID:	DOAJ054120756

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520			\|a The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity.
650		4	\|a Streptococcus pneumoniae
650		4	\|a anti-protein antibody
650		4	\|a colonization
650		4	\|a B cell depletion
650		4	\|a CD20
653		0	\|a Immunologic diseases. Allergy
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700	0		\|a Philip Felgner \|e verfasserin \|4 aut
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951			\|a AR
952			\|d 11 \|j 2021

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allfields	10.3389/fimmu.2020.611661 doi (DE-627)DOAJ054120756 (DE-599)DOAJ254598317059450e979cd18bc29cd6e8 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity. Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20 Immunologic diseases. Allergy Elisa Ramos-Sevillano verfasserin aut Rie Nakajima verfasserin aut Rafael Ramiro de Assis verfasserin aut Algis Jasinskas verfasserin aut David Goldblatt verfasserin aut Philip Felgner verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy Brown verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.611661 kostenfrei https://doaj.org/article/254598317059450e979cd18bc29cd6e8 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.611661/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
spelling	10.3389/fimmu.2020.611661 doi (DE-627)DOAJ054120756 (DE-599)DOAJ254598317059450e979cd18bc29cd6e8 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity. Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20 Immunologic diseases. Allergy Elisa Ramos-Sevillano verfasserin aut Rie Nakajima verfasserin aut Rafael Ramiro de Assis verfasserin aut Algis Jasinskas verfasserin aut David Goldblatt verfasserin aut Philip Felgner verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy Brown verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.611661 kostenfrei https://doaj.org/article/254598317059450e979cd18bc29cd6e8 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.611661/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
allfields_unstemmed	10.3389/fimmu.2020.611661 doi (DE-627)DOAJ054120756 (DE-599)DOAJ254598317059450e979cd18bc29cd6e8 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity. Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20 Immunologic diseases. Allergy Elisa Ramos-Sevillano verfasserin aut Rie Nakajima verfasserin aut Rafael Ramiro de Assis verfasserin aut Algis Jasinskas verfasserin aut David Goldblatt verfasserin aut Philip Felgner verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy Brown verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.611661 kostenfrei https://doaj.org/article/254598317059450e979cd18bc29cd6e8 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.611661/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
allfieldsGer	10.3389/fimmu.2020.611661 doi (DE-627)DOAJ054120756 (DE-599)DOAJ254598317059450e979cd18bc29cd6e8 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity. Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20 Immunologic diseases. Allergy Elisa Ramos-Sevillano verfasserin aut Rie Nakajima verfasserin aut Rafael Ramiro de Assis verfasserin aut Algis Jasinskas verfasserin aut David Goldblatt verfasserin aut Philip Felgner verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy Brown verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.611661 kostenfrei https://doaj.org/article/254598317059450e979cd18bc29cd6e8 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.611661/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
allfieldsSound	10.3389/fimmu.2020.611661 doi (DE-627)DOAJ054120756 (DE-599)DOAJ254598317059450e979cd18bc29cd6e8 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity. Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20 Immunologic diseases. Allergy Elisa Ramos-Sevillano verfasserin aut Rie Nakajima verfasserin aut Rafael Ramiro de Assis verfasserin aut Algis Jasinskas verfasserin aut David Goldblatt verfasserin aut Philip Felgner verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy Brown verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 11(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:11 year:2021 https://doi.org/10.3389/fimmu.2020.611661 kostenfrei https://doaj.org/article/254598317059450e979cd18bc29cd6e8 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2020.611661/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021
language	English
source	In Frontiers in Immunology 11(2021) volume:11 year:2021
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topic_facet	Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20 Immunologic diseases. Allergy
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authorswithroles_txt_mv	Giuseppe Ercoli @@aut@@ Elisa Ramos-Sevillano @@aut@@ Rie Nakajima @@aut@@ Rafael Ramiro de Assis @@aut@@ Algis Jasinskas @@aut@@ David Goldblatt @@aut@@ Philip Felgner @@aut@@ Gisbert Weckbecker @@aut@@ Jeremy Brown @@aut@@
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callnumber-first	R - Medicine
author	Giuseppe Ercoli
spellingShingle	Giuseppe Ercoli misc RC581-607 misc Streptococcus pneumoniae misc anti-protein antibody misc colonization misc B cell depletion misc CD20 misc Immunologic diseases. Allergy The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae
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topic_title	RC581-607 The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae Streptococcus pneumoniae anti-protein antibody colonization B cell depletion CD20
topic	misc RC581-607 misc Streptococcus pneumoniae misc anti-protein antibody misc colonization misc B cell depletion misc CD20 misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc Streptococcus pneumoniae misc anti-protein antibody misc colonization misc B cell depletion misc CD20 misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc Streptococcus pneumoniae misc anti-protein antibody misc colonization misc B cell depletion misc CD20 misc Immunologic diseases. Allergy
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title	The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae
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title_full	The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae
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author_browse	Giuseppe Ercoli Elisa Ramos-Sevillano Rie Nakajima Rafael Ramiro de Assis Algis Jasinskas David Goldblatt Philip Felgner Gisbert Weckbecker Jeremy Brown
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title_sort	influence of b cell depletion therapy on naturally acquired immunity to streptococcus pneumoniae
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title_auth	The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae
abstract	The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity.
abstractGer	The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity.
abstract_unstemmed	The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity.
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title_short	The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae
url	https://doi.org/10.3389/fimmu.2020.611661 https://doaj.org/article/254598317059450e979cd18bc29cd6e8 https://www.frontiersin.org/articles/10.3389/fimmu.2020.611661/full https://doaj.org/toc/1664-3224
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up_date	2024-07-03T21:26:14.045Z
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The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae

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