Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma

Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (i...
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Autor*in:	Bin Zheng [verfasserIn] Fang Xie [verfasserIn] Fajuan Cheng [verfasserIn] Jianwei Wang [verfasserIn] Zhongshun Yao [verfasserIn] Wei He [verfasserIn] Zhihong Niu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy

Übergeordnetes Werk:	In: Frontiers in Molecular Biosciences - Frontiers Media S.A., 2015, 8(2021)
Übergeordnetes Werk:	volume:8 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmolb.2021.760031

Katalog-ID:	DOAJ05412803X

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520			\|a Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer.
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allfields	10.3389/fmolb.2021.760031 doi (DE-627)DOAJ05412803X (DE-599)DOAJ5b1cd164c05b4bfc87d83cae0d531212 DE-627 ger DE-627 rakwb eng QH301-705.5 Bin Zheng verfasserin aut Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer. clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy Biology (General) Bin Zheng verfasserin aut Bin Zheng verfasserin aut Fang Xie verfasserin aut Fang Xie verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Jianwei Wang verfasserin aut Zhongshun Yao verfasserin aut Zhongshun Yao verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.760031 kostenfrei https://doaj.org/article/5b1cd164c05b4bfc87d83cae0d531212 kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
spelling	10.3389/fmolb.2021.760031 doi (DE-627)DOAJ05412803X (DE-599)DOAJ5b1cd164c05b4bfc87d83cae0d531212 DE-627 ger DE-627 rakwb eng QH301-705.5 Bin Zheng verfasserin aut Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer. clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy Biology (General) Bin Zheng verfasserin aut Bin Zheng verfasserin aut Fang Xie verfasserin aut Fang Xie verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Jianwei Wang verfasserin aut Zhongshun Yao verfasserin aut Zhongshun Yao verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.760031 kostenfrei https://doaj.org/article/5b1cd164c05b4bfc87d83cae0d531212 kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfields_unstemmed	10.3389/fmolb.2021.760031 doi (DE-627)DOAJ05412803X (DE-599)DOAJ5b1cd164c05b4bfc87d83cae0d531212 DE-627 ger DE-627 rakwb eng QH301-705.5 Bin Zheng verfasserin aut Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer. clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy Biology (General) Bin Zheng verfasserin aut Bin Zheng verfasserin aut Fang Xie verfasserin aut Fang Xie verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Jianwei Wang verfasserin aut Zhongshun Yao verfasserin aut Zhongshun Yao verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.760031 kostenfrei https://doaj.org/article/5b1cd164c05b4bfc87d83cae0d531212 kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsGer	10.3389/fmolb.2021.760031 doi (DE-627)DOAJ05412803X (DE-599)DOAJ5b1cd164c05b4bfc87d83cae0d531212 DE-627 ger DE-627 rakwb eng QH301-705.5 Bin Zheng verfasserin aut Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer. clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy Biology (General) Bin Zheng verfasserin aut Bin Zheng verfasserin aut Fang Xie verfasserin aut Fang Xie verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Jianwei Wang verfasserin aut Zhongshun Yao verfasserin aut Zhongshun Yao verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.760031 kostenfrei https://doaj.org/article/5b1cd164c05b4bfc87d83cae0d531212 kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsSound	10.3389/fmolb.2021.760031 doi (DE-627)DOAJ05412803X (DE-599)DOAJ5b1cd164c05b4bfc87d83cae0d531212 DE-627 ger DE-627 rakwb eng QH301-705.5 Bin Zheng verfasserin aut Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer. clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy Biology (General) Bin Zheng verfasserin aut Bin Zheng verfasserin aut Fang Xie verfasserin aut Fang Xie verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Fajuan Cheng verfasserin aut Jianwei Wang verfasserin aut Zhongshun Yao verfasserin aut Zhongshun Yao verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Wei He verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut Zhihong Niu verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.760031 kostenfrei https://doaj.org/article/5b1cd164c05b4bfc87d83cae0d531212 kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
language	English
source	In Frontiers in Molecular Biosciences 8(2021) volume:8 year:2021
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container_title	Frontiers in Molecular Biosciences
authorswithroles_txt_mv	Bin Zheng @@aut@@ Fang Xie @@aut@@ Fajuan Cheng @@aut@@ Jianwei Wang @@aut@@ Zhongshun Yao @@aut@@ Wei He @@aut@@ Zhihong Niu @@aut@@
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callnumber-first	Q - Science
author	Bin Zheng
spellingShingle	Bin Zheng misc QH301-705.5 misc clear cell renal carcinoma misc papillary renal cell carcinoma misc prognosis misc tumor microenvironment misc immunotherapy misc Biology (General) Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma
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topic_title	QH301-705.5 Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy
topic	misc QH301-705.5 misc clear cell renal carcinoma misc papillary renal cell carcinoma misc prognosis misc tumor microenvironment misc immunotherapy misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc clear cell renal carcinoma misc papillary renal cell carcinoma misc prognosis misc tumor microenvironment misc immunotherapy misc Biology (General)
topic_browse	misc QH301-705.5 misc clear cell renal carcinoma misc papillary renal cell carcinoma misc prognosis misc tumor microenvironment misc immunotherapy misc Biology (General)
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title	Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma
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title_full	Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma
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title_sort	integrative analysis of immune-related genes in the tumor microenvironment of renal clear cell carcinoma and renal papillary cell carcinoma
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title_auth	Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma
abstract	Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer.
abstractGer	Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer.
abstract_unstemmed	Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer.
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title_short	Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma
url	https://doi.org/10.3389/fmolb.2021.760031 https://doaj.org/article/5b1cd164c05b4bfc87d83cae0d531212 https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full https://doaj.org/toc/2296-889X
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up_date	2024-07-03T21:28:40.724Z
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Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma

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