Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate.

The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us...
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Autor*in:	Timothy Caulfield [verfasserIn] Jim Evans [verfasserIn] Amy McGuire [verfasserIn] Christopher McCabe [verfasserIn] Tania Bubela [verfasserIn] Robert Cook-Deegan [verfasserIn] Jennifer Fishman [verfasserIn] Stuart Hogarth [verfasserIn] Fiona A Miller [verfasserIn] Vardit Ravitsky [verfasserIn] Barbara Biesecker [verfasserIn] Pascal Borry [verfasserIn] Mildred K Cho [verfasserIn] June C Carroll [verfasserIn] Holly Etchegary [verfasserIn] Yann Joly [verfasserIn] Kazuto Kato [verfasserIn] Sandra Soo-Jin Lee [verfasserIn] Karen Rothenberg [verfasserIn] Pamela Sankar [verfasserIn] Michael J Szego [verfasserIn] Pilar Ossorio [verfasserIn] Daryl Pullman [verfasserIn] Francois Rousseau [verfasserIn] Wendy J Ungar [verfasserIn] Brenda Wilson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Übergeordnetes Werk:	In: PLoS Biology - Public Library of Science (PLoS), 2003, 11(2013), 11, p e1001699
Übergeordnetes Werk:	volume:11 ; year:2013 ; number:11, p e1001699

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.pbio.1001699

Katalog-ID:	DOAJ054133149

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allfields_unstemmed	10.1371/journal.pbio.1001699 doi (DE-627)DOAJ054133149 (DE-599)DOAJad7dc7b64fbc41bd87b9096edfe82feb DE-627 ger DE-627 rakwb eng QH301-705.5 Timothy Caulfield verfasserin aut Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy. Biology (General) Jim Evans verfasserin aut Amy McGuire verfasserin aut Christopher McCabe verfasserin aut Tania Bubela verfasserin aut Robert Cook-Deegan verfasserin aut Jennifer Fishman verfasserin aut Stuart Hogarth verfasserin aut Fiona A Miller verfasserin aut Vardit Ravitsky verfasserin aut Barbara Biesecker verfasserin aut Pascal Borry verfasserin aut Mildred K Cho verfasserin aut June C Carroll verfasserin aut Holly Etchegary verfasserin aut Yann Joly verfasserin aut Kazuto Kato verfasserin aut Sandra Soo-Jin Lee verfasserin aut Karen Rothenberg verfasserin aut Pamela Sankar verfasserin aut Michael J Szego verfasserin aut Pilar Ossorio verfasserin aut Daryl Pullman verfasserin aut Francois Rousseau verfasserin aut Wendy J Ungar verfasserin aut Brenda Wilson verfasserin aut In PLoS Biology Public Library of Science (PLoS), 2003 11(2013), 11, p e1001699 (DE-627)373755597 (DE-600)2126773-X 15457885 nnns volume:11 year:2013 number:11, p e1001699 https://doi.org/10.1371/journal.pbio.1001699 kostenfrei https://doaj.org/article/ad7dc7b64fbc41bd87b9096edfe82feb kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223516/pdf/?tool=EBI kostenfrei https://doaj.org/toc/1544-9173 Journal toc kostenfrei https://doaj.org/toc/1545-7885 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 11, p e1001699
allfieldsGer	10.1371/journal.pbio.1001699 doi (DE-627)DOAJ054133149 (DE-599)DOAJad7dc7b64fbc41bd87b9096edfe82feb DE-627 ger DE-627 rakwb eng QH301-705.5 Timothy Caulfield verfasserin aut Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy. Biology (General) Jim Evans verfasserin aut Amy McGuire verfasserin aut Christopher McCabe verfasserin aut Tania Bubela verfasserin aut Robert Cook-Deegan verfasserin aut Jennifer Fishman verfasserin aut Stuart Hogarth verfasserin aut Fiona A Miller verfasserin aut Vardit Ravitsky verfasserin aut Barbara Biesecker verfasserin aut Pascal Borry verfasserin aut Mildred K Cho verfasserin aut June C Carroll verfasserin aut Holly Etchegary verfasserin aut Yann Joly verfasserin aut Kazuto Kato verfasserin aut Sandra Soo-Jin Lee verfasserin aut Karen Rothenberg verfasserin aut Pamela Sankar verfasserin aut Michael J Szego verfasserin aut Pilar Ossorio verfasserin aut Daryl Pullman verfasserin aut Francois Rousseau verfasserin aut Wendy J Ungar verfasserin aut Brenda Wilson verfasserin aut In PLoS Biology Public Library of Science (PLoS), 2003 11(2013), 11, p e1001699 (DE-627)373755597 (DE-600)2126773-X 15457885 nnns volume:11 year:2013 number:11, p e1001699 https://doi.org/10.1371/journal.pbio.1001699 kostenfrei https://doaj.org/article/ad7dc7b64fbc41bd87b9096edfe82feb kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223516/pdf/?tool=EBI kostenfrei https://doaj.org/toc/1544-9173 Journal toc kostenfrei https://doaj.org/toc/1545-7885 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 11, p e1001699
allfieldsSound	10.1371/journal.pbio.1001699 doi (DE-627)DOAJ054133149 (DE-599)DOAJad7dc7b64fbc41bd87b9096edfe82feb DE-627 ger DE-627 rakwb eng QH301-705.5 Timothy Caulfield verfasserin aut Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy. Biology (General) Jim Evans verfasserin aut Amy McGuire verfasserin aut Christopher McCabe verfasserin aut Tania Bubela verfasserin aut Robert Cook-Deegan verfasserin aut Jennifer Fishman verfasserin aut Stuart Hogarth verfasserin aut Fiona A Miller verfasserin aut Vardit Ravitsky verfasserin aut Barbara Biesecker verfasserin aut Pascal Borry verfasserin aut Mildred K Cho verfasserin aut June C Carroll verfasserin aut Holly Etchegary verfasserin aut Yann Joly verfasserin aut Kazuto Kato verfasserin aut Sandra Soo-Jin Lee verfasserin aut Karen Rothenberg verfasserin aut Pamela Sankar verfasserin aut Michael J Szego verfasserin aut Pilar Ossorio verfasserin aut Daryl Pullman verfasserin aut Francois Rousseau verfasserin aut Wendy J Ungar verfasserin aut Brenda Wilson verfasserin aut In PLoS Biology Public Library of Science (PLoS), 2003 11(2013), 11, p e1001699 (DE-627)373755597 (DE-600)2126773-X 15457885 nnns volume:11 year:2013 number:11, p e1001699 https://doi.org/10.1371/journal.pbio.1001699 kostenfrei https://doaj.org/article/ad7dc7b64fbc41bd87b9096edfe82feb kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223516/pdf/?tool=EBI kostenfrei https://doaj.org/toc/1544-9173 Journal toc kostenfrei https://doaj.org/toc/1545-7885 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 11, p e1001699
language	English
source	In PLoS Biology 11(2013), 11, p e1001699 volume:11 year:2013 number:11, p e1001699
sourceStr	In PLoS Biology 11(2013), 11, p e1001699 volume:11 year:2013 number:11, p e1001699
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biology (General)
isfreeaccess_bool	true
container_title	PLoS Biology
authorswithroles_txt_mv	Timothy Caulfield @@aut@@ Jim Evans @@aut@@ Amy McGuire @@aut@@ Christopher McCabe @@aut@@ Tania Bubela @@aut@@ Robert Cook-Deegan @@aut@@ Jennifer Fishman @@aut@@ Stuart Hogarth @@aut@@ Fiona A Miller @@aut@@ Vardit Ravitsky @@aut@@ Barbara Biesecker @@aut@@ Pascal Borry @@aut@@ Mildred K Cho @@aut@@ June C Carroll @@aut@@ Holly Etchegary @@aut@@ Yann Joly @@aut@@ Kazuto Kato @@aut@@ Sandra Soo-Jin Lee @@aut@@ Karen Rothenberg @@aut@@ Pamela Sankar @@aut@@ Michael J Szego @@aut@@ Pilar Ossorio @@aut@@ Daryl Pullman @@aut@@ Francois Rousseau @@aut@@ Wendy J Ungar @@aut@@ Brenda Wilson @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	373755597
id	DOAJ054133149
language_de	englisch
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author	Timothy Caulfield
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topic_title	QH301-705.5 Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate
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title	Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate.
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title_full	Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate
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author_browse	Timothy Caulfield Jim Evans Amy McGuire Christopher McCabe Tania Bubela Robert Cook-Deegan Jennifer Fishman Stuart Hogarth Fiona A Miller Vardit Ravitsky Barbara Biesecker Pascal Borry Mildred K Cho June C Carroll Holly Etchegary Yann Joly Kazuto Kato Sandra Soo-Jin Lee Karen Rothenberg Pamela Sankar Michael J Szego Pilar Ossorio Daryl Pullman Francois Rousseau Wendy J Ungar Brenda Wilson
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title_sort	reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate
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title_auth	Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate.
abstract	The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy.
abstractGer	The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy.
abstract_unstemmed	The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy.
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title_short	Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate.
url	https://doi.org/10.1371/journal.pbio.1001699 https://doaj.org/article/ad7dc7b64fbc41bd87b9096edfe82feb https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223516/pdf/?tool=EBI https://doaj.org/toc/1544-9173 https://doaj.org/toc/1545-7885
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Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate.

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