Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were c...
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Autor*in:	Edoardo Spina [verfasserIn] Maria Antonietta Barbieri [verfasserIn] Giuseppe Cicala [verfasserIn] Jose de Leon [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	antipsychotic agents antibacterial agents antibiotics antitubercular antifungal agents antimalarials

Übergeordnetes Werk:	In: Pharmaceuticals - MDPI AG, 2005, 13(2020), 12, p 439
Übergeordnetes Werk:	volume:13 ; year:2020 ; number:12, p 439

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ph13120439

Katalog-ID:	DOAJ054338956

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language	English
source	In Pharmaceuticals 13(2020), 12, p 439 volume:13 year:2020 number:12, p 439
sourceStr	In Pharmaceuticals 13(2020), 12, p 439 volume:13 year:2020 number:12, p 439
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topic_facet	antipsychotic agents antibacterial agents antibiotics antitubercular antifungal agents antimalarials Medicine R Pharmacy and materia medica
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container_title	Pharmaceuticals
authorswithroles_txt_mv	Edoardo Spina @@aut@@ Maria Antonietta Barbieri @@aut@@ Giuseppe Cicala @@aut@@ Jose de Leon @@aut@@
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spellingShingle	Edoardo Spina misc RS1-441 misc antipsychotic agents misc antibacterial agents misc antibiotics misc antitubercular misc antifungal agents misc antimalarials misc Medicine misc R misc Pharmacy and materia medica Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
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title_auth	Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
abstract	This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed tables with practical recommendations for clinicians for: antibiotic DIs, antitubercular DIs, antifungal DIs, antiviral DIs, and other anti-infective DIs. Another table reflects that in clinical practice, DIs between atypical antipsychotics and anti-infective agents occur in patients also suffering an infection that may also influence the PK and PD mechanisms of both drugs (the atypical antipsychotic and the anti-infective agent(s)). These tables reflect the currently available literature and our current knowledge of the field and will need to be updated as new DI information becomes available.
abstractGer	This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed tables with practical recommendations for clinicians for: antibiotic DIs, antitubercular DIs, antifungal DIs, antiviral DIs, and other anti-infective DIs. Another table reflects that in clinical practice, DIs between atypical antipsychotics and anti-infective agents occur in patients also suffering an infection that may also influence the PK and PD mechanisms of both drugs (the atypical antipsychotic and the anti-infective agent(s)). These tables reflect the currently available literature and our current knowledge of the field and will need to be updated as new DI information becomes available.
abstract_unstemmed	This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed tables with practical recommendations for clinicians for: antibiotic DIs, antitubercular DIs, antifungal DIs, antiviral DIs, and other anti-infective DIs. Another table reflects that in clinical practice, DIs between atypical antipsychotics and anti-infective agents occur in patients also suffering an infection that may also influence the PK and PD mechanisms of both drugs (the atypical antipsychotic and the anti-infective agent(s)). These tables reflect the currently available literature and our current knowledge of the field and will need to be updated as new DI information becomes available.
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