Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility

The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not...
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Gespeichert in:

Autor*in:	Đorđević Valentina [verfasserIn] Nikolić A. [verfasserIn] Ljujić M. [verfasserIn] Nestorović A. [verfasserIn] Ristanović M. [verfasserIn] Tulić C. [verfasserIn] Radojković D. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	gene mutation GSTM1 GSTT1 male infertility MTHFR

Übergeordnetes Werk:	In: Archives of Biological Sciences - University of Belgrade, University of Novi Sad, 2010, 62(2010), 3, Seite 525-530
Übergeordnetes Werk:	volume:62 ; year:2010 ; number:3 ; pages:525-530

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.2298/ABS1003525D

Katalog-ID:	DOAJ054535697

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allfields	10.2298/ABS1003525D doi (DE-627)DOAJ054535697 (DE-599)DOAJcf4805f9a5d84a7b918b080931fc78a6 DE-627 ger DE-627 rakwb eng QH301-705.5 Đorđević Valentina verfasserin aut Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). . gene mutation GSTM1 GSTT1 male infertility MTHFR Biology (General) Nikolić A. verfasserin aut Ljujić M. verfasserin aut Nestorović A. verfasserin aut Ristanović M. verfasserin aut Tulić C. verfasserin aut Radojković D. verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 62(2010), 3, Seite 525-530 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:62 year:2010 number:3 pages:525-530 https://doi.org/10.2298/ABS1003525D kostenfrei https://doaj.org/article/cf4805f9a5d84a7b918b080931fc78a6 kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003525D.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2010 3 525-530
spelling	10.2298/ABS1003525D doi (DE-627)DOAJ054535697 (DE-599)DOAJcf4805f9a5d84a7b918b080931fc78a6 DE-627 ger DE-627 rakwb eng QH301-705.5 Đorđević Valentina verfasserin aut Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). . gene mutation GSTM1 GSTT1 male infertility MTHFR Biology (General) Nikolić A. verfasserin aut Ljujić M. verfasserin aut Nestorović A. verfasserin aut Ristanović M. verfasserin aut Tulić C. verfasserin aut Radojković D. verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 62(2010), 3, Seite 525-530 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:62 year:2010 number:3 pages:525-530 https://doi.org/10.2298/ABS1003525D kostenfrei https://doaj.org/article/cf4805f9a5d84a7b918b080931fc78a6 kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003525D.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2010 3 525-530
allfields_unstemmed	10.2298/ABS1003525D doi (DE-627)DOAJ054535697 (DE-599)DOAJcf4805f9a5d84a7b918b080931fc78a6 DE-627 ger DE-627 rakwb eng QH301-705.5 Đorđević Valentina verfasserin aut Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). . gene mutation GSTM1 GSTT1 male infertility MTHFR Biology (General) Nikolić A. verfasserin aut Ljujić M. verfasserin aut Nestorović A. verfasserin aut Ristanović M. verfasserin aut Tulić C. verfasserin aut Radojković D. verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 62(2010), 3, Seite 525-530 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:62 year:2010 number:3 pages:525-530 https://doi.org/10.2298/ABS1003525D kostenfrei https://doaj.org/article/cf4805f9a5d84a7b918b080931fc78a6 kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003525D.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2010 3 525-530
allfieldsGer	10.2298/ABS1003525D doi (DE-627)DOAJ054535697 (DE-599)DOAJcf4805f9a5d84a7b918b080931fc78a6 DE-627 ger DE-627 rakwb eng QH301-705.5 Đorđević Valentina verfasserin aut Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). . gene mutation GSTM1 GSTT1 male infertility MTHFR Biology (General) Nikolić A. verfasserin aut Ljujić M. verfasserin aut Nestorović A. verfasserin aut Ristanović M. verfasserin aut Tulić C. verfasserin aut Radojković D. verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 62(2010), 3, Seite 525-530 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:62 year:2010 number:3 pages:525-530 https://doi.org/10.2298/ABS1003525D kostenfrei https://doaj.org/article/cf4805f9a5d84a7b918b080931fc78a6 kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003525D.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2010 3 525-530
allfieldsSound	10.2298/ABS1003525D doi (DE-627)DOAJ054535697 (DE-599)DOAJcf4805f9a5d84a7b918b080931fc78a6 DE-627 ger DE-627 rakwb eng QH301-705.5 Đorđević Valentina verfasserin aut Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). . gene mutation GSTM1 GSTT1 male infertility MTHFR Biology (General) Nikolić A. verfasserin aut Ljujić M. verfasserin aut Nestorović A. verfasserin aut Ristanović M. verfasserin aut Tulić C. verfasserin aut Radojković D. verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 62(2010), 3, Seite 525-530 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:62 year:2010 number:3 pages:525-530 https://doi.org/10.2298/ABS1003525D kostenfrei https://doaj.org/article/cf4805f9a5d84a7b918b080931fc78a6 kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003525D.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2010 3 525-530
language	English
source	In Archives of Biological Sciences 62(2010), 3, Seite 525-530 volume:62 year:2010 number:3 pages:525-530
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topic_facet	gene mutation GSTM1 GSTT1 male infertility MTHFR Biology (General)
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authorswithroles_txt_mv	Đorđević Valentina @@aut@@ Nikolić A. @@aut@@ Ljujić M. @@aut@@ Nestorović A. @@aut@@ Ristanović M. @@aut@@ Tulić C. @@aut@@ Radojković D. @@aut@@
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callnumber-first	Q - Science
author	Đorđević Valentina
spellingShingle	Đorđević Valentina misc QH301-705.5 misc gene mutation misc GSTM1 misc GSTT1 misc male infertility misc MTHFR misc Biology (General) Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility
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topic_title	QH301-705.5 Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility gene mutation GSTM1 GSTT1 male infertility MTHFR
topic	misc QH301-705.5 misc gene mutation misc GSTM1 misc GSTT1 misc male infertility misc MTHFR misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc gene mutation misc GSTM1 misc GSTT1 misc male infertility misc MTHFR misc Biology (General)
topic_browse	misc QH301-705.5 misc gene mutation misc GSTM1 misc GSTT1 misc male infertility misc MTHFR misc Biology (General)
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title	Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility
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title_full	Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility
author_sort	Đorđević Valentina
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author_browse	Đorđević Valentina Nikolić A. Ljujić M. Nestorović A. Ristanović M. Tulić C. Radojković D.
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title_sort	combined effect of gstm1 gene deletion, gstt1 gene deletion and mthfr c677t mutation in male infertility
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title_auth	Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility
abstract	The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). .
abstractGer	The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). .
abstract_unstemmed	The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). .
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container_issue	3
title_short	Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility
url	https://doi.org/10.2298/ABS1003525D https://doaj.org/article/cf4805f9a5d84a7b918b080931fc78a6 http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003525D.pdf https://doaj.org/toc/0354-4664
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Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility

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